PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23955302-6	2013	These data identify a role for the TSC in responding to ROS at the peroxisome, and identify the peroxisome as a signalling organelle involved in regulation of mTORC1.	Reactive Oxygen Species	56-59	TSC complex subunit 1	Homo sapiens	35-38	
33860865-5	2021	The study also reveals that treatment of TSC mutant cells with the drug candidate Proxison combined with reduced concentration of rapamycin can increase production of reactive oxygen species (ROS), can modify miRNA expression pattern associated with p53 regulation and can reduce cell viability.	Reactive Oxygen Species	167-190	TSC complex subunit 1	Homo sapiens	41-44	
33860865-5	2021	The study also reveals that treatment of TSC mutant cells with the drug candidate Proxison combined with reduced concentration of rapamycin can increase production of reactive oxygen species (ROS), can modify miRNA expression pattern associated with p53 regulation and can reduce cell viability.	Reactive Oxygen Species	192-195	TSC complex subunit 1	Homo sapiens	41-44	
29484365-8	2018	LicA can activate the ULK1/Atg13 complex which is upstream of autophagy, additionally, LicA also can promote ROS generation, ROS trigger the expression level of TSC1/2 complex, PRAS40, CTMP, PP2A, PDK1 and Rubicon change, these molecules are upstream of autophagy.	Reactive Oxygen Species	125-128	TSC complex subunit 1	Homo sapiens	161-167	
23955302-2	2013	We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS).	Reactive Oxygen Species	157-180	TSC complex subunit 1	Homo sapiens	47-50	
23955302-2	2013	We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS).	Reactive Oxygen Species	157-180	TSC complex subunit 1	Homo sapiens	69-73	
23955302-2	2013	We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS).	Reactive Oxygen Species	182-185	TSC complex subunit 1	Homo sapiens	47-50	
23955302-2	2013	We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS).	Reactive Oxygen Species	182-185	TSC complex subunit 1	Homo sapiens	69-73	
29522719-5	2018	We further showed that conditional knockout of Tsc1 led to enhanced proliferation and increased reactive oxygen species (ROS) production and phagocytosis in AMs.	Reactive Oxygen Species	96-119	TSC complex subunit 1	Homo sapiens	47-51	
29522719-5	2018	We further showed that conditional knockout of Tsc1 led to enhanced proliferation and increased reactive oxygen species (ROS) production and phagocytosis in AMs.	Reactive Oxygen Species	121-124	TSC complex subunit 1	Homo sapiens	47-51	
23257465-4	2012	Many signaling molecules such as FoxOs, ATM, mTOR, TSC1, Bmi1 and AKT play a significant role in ROS-induced HSC senescence.	Reactive Oxygen Species	97-100	TSC complex subunit 1	Homo sapiens	51-55	
22362037-5	2012	Furthermore, TSC1 is critical for mast cell survival through multiple pathways of apoptosis including the down-regulation of p53, miR-34a, reactive oxygen species, and the up-regulation of Bcl-2.	Reactive Oxygen Species	139-162	TSC complex subunit 1	Homo sapiens	13-17	
18809716-3	2008	We demonstrate that Tsc1 deletion in the HSCs drives them from quiescence into rapid cycling, with increased mitochondrial biogenesis and elevated levels of reactive oxygen species (ROS).	Reactive Oxygen Species	157-180	TSC complex subunit 1	Homo sapiens	20-24	
18809716-3	2008	We demonstrate that Tsc1 deletion in the HSCs drives them from quiescence into rapid cycling, with increased mitochondrial biogenesis and elevated levels of reactive oxygen species (ROS).	Reactive Oxygen Species	182-185	TSC complex subunit 1	Homo sapiens	20-24