PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24123723-2 2014 The arterial proteins collagen and elastin may also undergo structural and functional changes due to damage caused by ROS. Reactive Oxygen Species 118-121 elastin Homo sapiens 35-42 25149191-11 2014 CONCLUSION: Our results suggest that PPARdelta-mediated modulation of MMP-2 secretion and elastin expression may contribute to the maintenance of skin integrity by inhibiting ROS generation. Reactive Oxygen Species 175-178 elastin Homo sapiens 90-97 15654955-7 2005 These data indicate that reactive oxygen species may play a role in tropoelastin expression by heat, but not in fibrillin-1 expression. Reactive Oxygen Species 25-48 elastin Homo sapiens 68-80 21726534-6 2011 Elastin oxidized by reactive oxygen species (ROS) liberated more unconjugated DES and IDE than did non-oxidized elastin when incubated with MMP-12 or neutrophil elastase. Reactive Oxygen Species 20-43 elastin Homo sapiens 0-7 21726534-6 2011 Elastin oxidized by reactive oxygen species (ROS) liberated more unconjugated DES and IDE than did non-oxidized elastin when incubated with MMP-12 or neutrophil elastase. Reactive Oxygen Species 45-48 elastin Homo sapiens 0-7 20564559-7 2010 These results indicate that the inversion rate to D-form of Asp residues in skin elastin is accelerated by generation of reactive oxygen species (ROS), and that oxidative stress might be closely related to D-Asp formation in aging proteins. Reactive Oxygen Species 121-144 elastin Homo sapiens 81-88 20564559-7 2010 These results indicate that the inversion rate to D-form of Asp residues in skin elastin is accelerated by generation of reactive oxygen species (ROS), and that oxidative stress might be closely related to D-Asp formation in aging proteins. Reactive Oxygen Species 146-149 elastin Homo sapiens 81-88 19709383-0 2009 Involvement of reactive oxygen species in TGF-beta1-induced tropoelastin expression by human dermal fibroblasts. Reactive Oxygen Species 15-38 elastin Homo sapiens 60-72 19709383-8 2009 These results indicate that Smad and MAPK pathways mediate TGF-beta1-induced TE expression and that ROS are required for both early signal transduction and later steps that increase elastin. Reactive Oxygen Species 100-103 elastin Homo sapiens 182-189 24438160-3 2014 In the skin, ROS are able to affect the production of collagen and elastin, the main components of the extracellular matrix (ECM). Reactive Oxygen Species 13-16 elastin Homo sapiens 67-74 15537639-6 2005 Our experimental evidence also demonstrates the existence of an opposite effect, in which higher, but not cytotoxic concentrations of iron (100-400 microm) induced the production of intracellular reactive oxygen species that coincided with a significant decrease in elastin message stability and the disappearance of iron-dependent stimulatory effect on elastogenesis. Reactive Oxygen Species 196-219 elastin Homo sapiens 266-273 11860423-0 2002 Reactive oxygen species activate the human elastin promoter in a transgenic model of cutaneous photoaging. Reactive Oxygen Species 0-23 elastin Homo sapiens 43-50 9165309-0 1997 Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts. Reactive Oxygen Species 10-33 elastin Homo sapiens 41-48 9165309-1 1997 The effects of ultraviolet A (UVA) and reactive oxygen species (ROS), generated by a xanthine and xanthine oxidase (XOD) system, on the mRNA expression of elastin, were investigated using cultured human dermal fibroblasts. Reactive Oxygen Species 39-62 elastin Homo sapiens 155-162 9165309-1 1997 The effects of ultraviolet A (UVA) and reactive oxygen species (ROS), generated by a xanthine and xanthine oxidase (XOD) system, on the mRNA expression of elastin, were investigated using cultured human dermal fibroblasts. Reactive Oxygen Species 64-67 elastin Homo sapiens 155-162 9165309-4 1997 In contrast, ROS resulted in a dose-related increase in the level of elastin mRNA up to 1.8-fold in cultured human dermal fibroblasts. Reactive Oxygen Species 13-16 elastin Homo sapiens 69-76 9165309-5 1997 Catalase, used as scavenger, essentially prevented the ROS induced alterations in elastin mRNA levels. Reactive Oxygen Species 55-58 elastin Homo sapiens 82-89 9165309-6 1997 These results suggest that ROS produced in the dermis may contribute to elastin deposition observed in photoaging skin. Reactive Oxygen Species 27-30 elastin Homo sapiens 72-79 2550876-8 1989 The binding of elastin peptides triggers several cellular reactions such as chemotaxis, Ca++ influx (increase of Ca++i) and with mononuclear blood cells release of lytic enzymes and oxygen radicals. Reactive Oxygen Species 182-197 elastin Homo sapiens 15-22 10761632-5 1999 The demonstration of the presence of the elastin receptor on leukocytes facilitated the detailed description of the transmission pathway from receptor to the intracellular sites activated by the receptor: modifications of ion fluxes, increase of elastase production and excretion of reactive oxygen species, superoxide and NO*. Reactive Oxygen Species 283-306 elastin Homo sapiens 41-48 9808343-0 1998 In vitro degradation of tropoelastin by reactive oxygen species. Reactive Oxygen Species 40-63 elastin Homo sapiens 24-36 9808343-1 1998 The effects of reactive oxygen species (ROS) on elastin molecules (tropoelastin) were studied in vitro. Reactive Oxygen Species 40-43 elastin Homo sapiens 48-55 9808343-1 1998 The effects of reactive oxygen species (ROS) on elastin molecules (tropoelastin) were studied in vitro. Reactive Oxygen Species 40-43 elastin Homo sapiens 67-79 9808343-2 1998 ROS generated by ultraviolet A and hematoporphyrin rapidly degraded tropoelastin within 5 min. Reactive Oxygen Species 0-3 elastin Homo sapiens 68-80 9808343-6 1998 ROS induced by the xanthine/xanthine oxidase system also degraded tropoelastin within 6 h. The degradation was blocked by catalase but not by superoxide dismutase (SOD). Reactive Oxygen Species 0-3 elastin Homo sapiens 66-78 9808343-7 1998 ROS generated by copper-ascorbate seems to be unique in that it cleaves relatively specific sites of the tropoelastin molecule. Reactive Oxygen Species 0-3 elastin Homo sapiens 105-117 9808343-8 1998 Thus ROS may play a degradative role in elastin metabolism which may cause the elastolytic changes or the deposition of fragmented elastic fibers in photoaged skin or age-related elastolytic disorders. Reactive Oxygen Species 5-8 elastin Homo sapiens 40-47 31161598-4 2019 This study was conducted to determine how the VGVAPG peptide, liberated from elastin during the aging process and under pathological conditions, affects ROS production and activities of antioxidant enzymes in undifferentiated, proliferating SH-SY5Y cells. Reactive Oxygen Species 153-156 elastin Homo sapiens 77-84 30926475-6 2019 Moreover, TGF-beta causes accumulation of reactive oxygen species leading to further degradation of elastin fibers. Reactive Oxygen Species 42-65 elastin Homo sapiens 100-107