PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31261663-6 2019 We found that CORM-2 induced HO-1 expression via the activation of protein kinase C (PKC)alpha and proline-rich tyrosine kinase (Pyk2), which was mediated through Nox-derived ROS generation using pharmacological inhibitors or small interfering ribonucleic acids (siRNAs). Reactive Oxygen Species 175-178 protein tyrosine kinase 2 beta Homo sapiens 129-133 33293849-5 2020 Conversely, low-level local ROS play an important role both as redox-signaling molecules in a wide spectrum of pathways involved in the maintenance of cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR), and regulating key transcription factors (NFkappaB/IkappaB, Nrf2/KEAP1, AP-1, p53, HIF-1). Reactive Oxygen Species 28-31 protein tyrosine kinase 2 beta Homo sapiens 183-186 32798562-0 2020 Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Reactive Oxygen Species 78-81 protein tyrosine kinase 2 beta Homo sapiens 96-99 32798562-12 2020 SIGNIFICANCE: Capillarisin protected SH-SY5Y cells against bupivacaine-induced apoptosis by inhibiting oxidative stress, mitochondrial injury, and endoplasmic reticulum stress via ROS-mediated of PI3K/PKB pathway. Reactive Oxygen Species 180-183 protein tyrosine kinase 2 beta Homo sapiens 201-204 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Reactive Oxygen Species 176-199 protein tyrosine kinase 2 beta Homo sapiens 76-92 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Reactive Oxygen Species 201-204 protein tyrosine kinase 2 beta Homo sapiens 76-92 31261663-10 2019 These results suggested that in HTSMCs, CORM-2 activates PKCalpha/Pyk2-dependent Nox/ROS/ERK1/2/AP-1, leading to HO-1 up-regulation, which suppresses the lipopolysaccharide (LPS)-induced airway inflammation. Reactive Oxygen Species 85-88 protein tyrosine kinase 2 beta Homo sapiens 66-70 29706964-13 2018 ROS activates the phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling in many cancers. Reactive Oxygen Species 0-3 protein tyrosine kinase 2 beta Homo sapiens 48-64 29723979-6 2018 Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B, PKB (PTEN/AKT) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ROS quenching. Reactive Oxygen Species 239-242 protein tyrosine kinase 2 beta Homo sapiens 58-74 29723979-6 2018 Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B, PKB (PTEN/AKT) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ROS quenching. Reactive Oxygen Species 239-242 protein tyrosine kinase 2 beta Homo sapiens 76-79 30637731-11 2019 After I/R, Pyk2 activated prosurvival signaling molecules and prevented excessive increases in reactive oxygen species, thereby affording protection from I/R injury. Reactive Oxygen Species 95-118 protein tyrosine kinase 2 beta Homo sapiens 11-15 25929187-2 2015 A number of reports indicate that PYK2 is a redox sensitive kinase that must be activated by an estrogen-induced reactive oxygen species (ROS). Reactive Oxygen Species 113-136 protein tyrosine kinase 2 beta Homo sapiens 34-38 28762881-6 2017 PTK-lysine triisocyanate (LTI) scaffolds degraded significantly in vitro under both oxidative and hydrolytic conditions whereas PTK-hexamethylene diisocyanate trimer (HDIt) scaffolds were resistant to hydrolytic breakdown and degraded exclusively through an ROS-dependent mechanism. Reactive Oxygen Species 258-261 protein tyrosine kinase 2 beta Homo sapiens 0-3 28762881-6 2017 PTK-lysine triisocyanate (LTI) scaffolds degraded significantly in vitro under both oxidative and hydrolytic conditions whereas PTK-hexamethylene diisocyanate trimer (HDIt) scaffolds were resistant to hydrolytic breakdown and degraded exclusively through an ROS-dependent mechanism. Reactive Oxygen Species 258-261 protein tyrosine kinase 2 beta Homo sapiens 128-131 27602957-6 2016 Inhibition of Pyk2 is caused by the suppression of reactive oxygen species, and leads to downregulation of the Wnt/beta-catenin signaling pathway. Reactive Oxygen Species 51-74 protein tyrosine kinase 2 beta Homo sapiens 14-18 29143372-9 2018 Collectively, our results suggest that PKC/NOX-mediated generation of ROS and subsequent activation of PARP-1 play a role in Abeta42 -induced TRPM2 channel activation and TRPM2-dependent activation of the PYK2/MEK/ERK signalling pathway acts as a positive feedback to further facilitate activation of PARP-1 and TRPM2 channel. Reactive Oxygen Species 70-73 protein tyrosine kinase 2 beta Homo sapiens 205-209 25929187-2 2015 A number of reports indicate that PYK2 is a redox sensitive kinase that must be activated by an estrogen-induced reactive oxygen species (ROS). Reactive Oxygen Species 138-141 protein tyrosine kinase 2 beta Homo sapiens 34-38 24707959-7 2014 Reactive oxygen species donors and stimulators of the phosphoinositide 3-kinase/protein kinase B and MAPK pathways can be used to increase the production yield of ASCs. Reactive Oxygen Species 0-23 protein tyrosine kinase 2 beta Homo sapiens 80-96 25889845-13 2015 ROS inhibitor apocynin not only inhibited alphavbeta3 integrin expression and the phosphorylation levels of FAK and Pyk2, but also suppressed the migratory and invasive capacity of U251 glioma cells under hypoxia. Reactive Oxygen Species 0-3 protein tyrosine kinase 2 beta Homo sapiens 116-120 25415317-1 2014 BACKGROUND: We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation. Reactive Oxygen Species 208-211 protein tyrosine kinase 2 beta Homo sapiens 74-78 25415317-2 2014 In other cell systems, NOX-dependent ROS formation is facilitated by Pyk2, which along with its closely related homologue FAK are known to be activated and phosphorylated downstream of ligand binding to GPVI. Reactive Oxygen Species 37-40 protein tyrosine kinase 2 beta Homo sapiens 69-73 25415317-3 2014 AIMS: To evaluate the relative roles of Pyk2 and FAK in GPVI-dependent ROS formation and to determine their location within the GPVI signaling pathway. Reactive Oxygen Species 71-74 protein tyrosine kinase 2 beta Homo sapiens 40-44 22773695-6 2012 The increase of ROS level resulted in activation of the c-Src/epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor (NF)-kappaB cascade. Reactive Oxygen Species 16-19 protein tyrosine kinase 2 beta Homo sapiens 139-155 15772258-8 2005 The capacitation-related increases in phospho-MEK-like proteins induced by FCSu, H(2)O(2), and spermine-NONOate were similarly modulated by PKA, PKC, and PTK, suggesting ROS as mediators in this phenomenon. Reactive Oxygen Species 170-173 protein tyrosine kinase 2 beta Homo sapiens 154-157 20688918-0 2010 Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes. Reactive Oxygen Species 75-98 protein tyrosine kinase 2 beta Homo sapiens 34-38 20688918-6 2010 We sought to identify a Ca(2+)-regulated pathway that could trigger Pyk2 phosphorylation in T cells and found that ionomycin stimulated the production of reactive oxygen species and an H(2)O(2) scavenger inhibited ionomycin-induced Pyk2 phosphorylation. Reactive Oxygen Species 154-177 protein tyrosine kinase 2 beta Homo sapiens 68-72 20688918-6 2010 We sought to identify a Ca(2+)-regulated pathway that could trigger Pyk2 phosphorylation in T cells and found that ionomycin stimulated the production of reactive oxygen species and an H(2)O(2) scavenger inhibited ionomycin-induced Pyk2 phosphorylation. Reactive Oxygen Species 154-177 protein tyrosine kinase 2 beta Homo sapiens 232-236 20688918-8 2010 These data support the conclusion that Ca(2+) mobilization induces the production of reactive oxygen species, which in turn activate the Erk pathway, leading to Src-family kinase-dependent Pyk2 phosphorylation. Reactive Oxygen Species 85-108 protein tyrosine kinase 2 beta Homo sapiens 189-193 20688918-9 2010 Our data demonstrate that Pyk2 is not a Ca(2+)-dependent kinase in T cells but instead, increased intracellular Ca(2+) induces Pyk2 phosphorylation through production of reactive oxygen species. Reactive Oxygen Species 170-193 protein tyrosine kinase 2 beta Homo sapiens 26-30 20688918-9 2010 Our data demonstrate that Pyk2 is not a Ca(2+)-dependent kinase in T cells but instead, increased intracellular Ca(2+) induces Pyk2 phosphorylation through production of reactive oxygen species. Reactive Oxygen Species 170-193 protein tyrosine kinase 2 beta Homo sapiens 127-131 20688918-10 2010 These findings are consistent with the possibility that Pyk2 acts as an early sensor of numerous extracellular signals that trigger a Ca(2+) flux and/or reactive oxygen species to amplify tyrosine phosphorylation signaling events. Reactive Oxygen Species 153-176 protein tyrosine kinase 2 beta Homo sapiens 56-60 17494630-8 2007 These pathways, which may be activated simultaneously or selectively, elevate [Ca(2+)](i), activate Src and the ERK1/2 kinase pathways, and activate phosphoinositide 3-kinase and protein kinase B (Akt), NF-kappaB, and reactive oxygen species. Reactive Oxygen Species 218-241 protein tyrosine kinase 2 beta Homo sapiens 179-195 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Reactive Oxygen Species 28-31 protein tyrosine kinase 2 beta Homo sapiens 154-170 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Reactive Oxygen Species 28-31 protein tyrosine kinase 2 beta Homo sapiens 172-175 20446899-2 2010 This study suggested that G2/M cell cycle arrest was triggered by ROS/NO productions with regulations of p53, p21, cell division cycle 25C (Cdc25C), Cdc2 and cyclin B1, which were able to be prevented by protein tyrosine kinase (PTK) activity inhibitor genistein or JNK inhibitor SP600125. Reactive Oxygen Species 66-69 protein tyrosine kinase 2 beta Homo sapiens 229-232 20446899-4 2010 These observations provide a distinct look at PTK pathway for its suppressive effect on G2/M transition by inductions of ROS/NO generations. Reactive Oxygen Species 121-124 protein tyrosine kinase 2 beta Homo sapiens 46-49 17034354-4 2006 The authors review the principal growth-promoting intracellular signaling pathways that are activated by ROS in cardiac myocytes, namely the mitogen-activated protein kinase cascades (extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinases, and p38-mitogen-activated protein kinases) and the phosphoinositide 3-kinase/protein kinase B (Akt) pathway. Reactive Oxygen Species 105-108 protein tyrosine kinase 2 beta Homo sapiens 331-347 15778498-8 2005 These results implicate Pyk2 in the reduced cell-cell adhesion induced by the Rac-mediated production of ROS through the tyrosine phosphorylation of beta-catenin. Reactive Oxygen Species 105-108 protein tyrosine kinase 2 beta Homo sapiens 24-28 15865435-8 2005 The functional consequences of E2-induced ROS formation included the enhanced cell motility as shown by the increase in cdc42 and activation of Pyk2 and the increased phosphorylation of signaling proteins c-jun and CREB. Reactive Oxygen Species 42-45 protein tyrosine kinase 2 beta Homo sapiens 144-148 15203192-0 2004 Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells. Reactive Oxygen Species 0-23 protein tyrosine kinase 2 beta Homo sapiens 75-78 15843166-3 2005 A cellular signaling cascade that is activated by several types of reactive oxygen species is the phosphoinositide 3"-kinase (PI 3-kinase)/protein kinase B (PKB) pathway, which regulates cellular survival and fuel metabolism, thus establishing a link between oxidative stress and signaling in neoplastic, metabolic or degenerative diseases. Reactive Oxygen Species 67-90 protein tyrosine kinase 2 beta Homo sapiens 139-155 15944312-0 2005 Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. Reactive Oxygen Species 101-124 protein tyrosine kinase 2 beta Homo sapiens 17-47 15944312-7 2005 Both dominant negative pyk2 and a pyk2-selective inhibitor prevented restoration of ROS production induced by TNF-alpha, GM-CSF, and platelet-activating factor, and this loss of pyk2 activity resulted in decreased Vav1 tyrosine phosphorylation and subsequent Rac2 activation. Reactive Oxygen Species 84-87 protein tyrosine kinase 2 beta Homo sapiens 23-27 15944312-7 2005 Both dominant negative pyk2 and a pyk2-selective inhibitor prevented restoration of ROS production induced by TNF-alpha, GM-CSF, and platelet-activating factor, and this loss of pyk2 activity resulted in decreased Vav1 tyrosine phosphorylation and subsequent Rac2 activation. Reactive Oxygen Species 84-87 protein tyrosine kinase 2 beta Homo sapiens 34-38 15944312-7 2005 Both dominant negative pyk2 and a pyk2-selective inhibitor prevented restoration of ROS production induced by TNF-alpha, GM-CSF, and platelet-activating factor, and this loss of pyk2 activity resulted in decreased Vav1 tyrosine phosphorylation and subsequent Rac2 activation. Reactive Oxygen Species 84-87 protein tyrosine kinase 2 beta Homo sapiens 34-38 15203192-3 2004 However, a possible role for ROS generation in mediating the ET-1 response on extracellular signal-regulated kinases 1 and 2 (ERK1/2), protein kinase B (PKB), and protein tyrosine kinase 2 (Pyk2), key components of the growth-promoting and proliferative signaling pathways, has not been examined in detail. Reactive Oxygen Species 29-32 protein tyrosine kinase 2 beta Homo sapiens 135-151 15203192-3 2004 However, a possible role for ROS generation in mediating the ET-1 response on extracellular signal-regulated kinases 1 and 2 (ERK1/2), protein kinase B (PKB), and protein tyrosine kinase 2 (Pyk2), key components of the growth-promoting and proliferative signaling pathways, has not been examined in detail. Reactive Oxygen Species 29-32 protein tyrosine kinase 2 beta Homo sapiens 153-156 15203192-4 2004 Our aim was to investigate the involvement of ROS in ET-1-mediated activation of ERK1/2, PKB, and Pyk2 in A-10 VSMCs. Reactive Oxygen Species 46-49 protein tyrosine kinase 2 beta Homo sapiens 89-92 12213802-0 2002 Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. Reactive Oxygen Species 13-36 protein tyrosine kinase 2 beta Homo sapiens 103-119 15158121-8 2004 Inhibition of Pyk2 activation also suppressed Rac1 activation and reactive oxygen species (ROS) production. Reactive Oxygen Species 66-89 protein tyrosine kinase 2 beta Homo sapiens 14-18 15158121-8 2004 Inhibition of Pyk2 activation also suppressed Rac1 activation and reactive oxygen species (ROS) production. Reactive Oxygen Species 91-94 protein tyrosine kinase 2 beta Homo sapiens 14-18 12682076-0 2003 Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity. Reactive Oxygen Species 31-54 protein tyrosine kinase 2 beta Homo sapiens 0-16 12361705-0 2002 Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. Reactive Oxygen Species 0-23 protein tyrosine kinase 2 beta Homo sapiens 98-101 12361705-6 2002 Accordingly, we assessed the ability of ROS to activate MAPK and PKB. Reactive Oxygen Species 40-43 protein tyrosine kinase 2 beta Homo sapiens 65-68 12361705-8 2002 ROS-induced PKB activation was abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002, suggesting that PI3-K is an upstream mediator of PKB activation in 7721 cells. Reactive Oxygen Species 0-3 protein tyrosine kinase 2 beta Homo sapiens 12-15 11715414-12 1999 The mechanism of decreasing ROS may be involved in down-regulating Ca(2+)-PKC and PTK signal transduction pathway activities that are upstream control systems for NADPH oxidase activation. Reactive Oxygen Species 28-31 protein tyrosine kinase 2 beta Homo sapiens 82-85 12361705-8 2002 ROS-induced PKB activation was abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002, suggesting that PI3-K is an upstream mediator of PKB activation in 7721 cells. Reactive Oxygen Species 0-3 protein tyrosine kinase 2 beta Homo sapiens 155-158 12361705-9 2002 Transfection with sense PKB cDNA promoted c-fos and c-jun expression in 7721 cells, suggesting that ROS may regulate c-fos and c-jun expression via the PKB pathway. Reactive Oxygen Species 100-103 protein tyrosine kinase 2 beta Homo sapiens 24-27 12361705-9 2002 Transfection with sense PKB cDNA promoted c-fos and c-jun expression in 7721 cells, suggesting that ROS may regulate c-fos and c-jun expression via the PKB pathway. Reactive Oxygen Species 100-103 protein tyrosine kinase 2 beta Homo sapiens 152-155 12361705-13 2002 Taken together, we found that ROS regulate hepatoma cell growth via specific signaling pathways (cross-talk between PI3-K/PKB and JNK pathway) which may provide a novel clue to elucidate the mechanism of hepatoma carcinogenesis. Reactive Oxygen Species 30-33 protein tyrosine kinase 2 beta Homo sapiens 122-125 11031201-3 2000 Both of these reactive oxygen species serve as second messengers to activate multiple intracellular proteins and enzymes, including the epidermal growth factor receptor, c-Src, p38 mitogen-activated protein kinase, Ras, and Akt/protein kinase B. Reactive Oxygen Species 14-37 protein tyrosine kinase 2 beta Homo sapiens 228-244 10965882-3 2000 However, whether ROS contribute to the Ang II-induced PTK and/or ERK activation in vascular smooth muscle cells (VSMCs) remains largely unclear. Reactive Oxygen Species 17-20 protein tyrosine kinase 2 beta Homo sapiens 54-57 10965882-4 2000 Here, we have investigated the possible involvement of ROS in Ang II-induced PTK and ERK activation. Reactive Oxygen Species 55-58 protein tyrosine kinase 2 beta Homo sapiens 77-80 10965882-9 2000 From these data, we conclude that ROS play a critical role in the Ang II-induced PTK and ERK activation in VSMCs, thereby contributing to vascular growth associated with enhanced Ang II activity. Reactive Oxygen Species 34-37 protein tyrosine kinase 2 beta Homo sapiens 81-84 10428852-0 1999 Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. Reactive Oxygen Species 0-23 protein tyrosine kinase 2 beta Homo sapiens 54-70