PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18252813-10 2008 Aortas from apoE-KO mice showed a significant generation of reactive oxygen species. Reactive Oxygen Species 60-83 apolipoprotein E Mus musculus 12-16 19546345-11 2009 These results showed that long-term oral estrogen treatment reduces ROS levels and atherosclerosis progression in apoE(-/-) mice. Reactive Oxygen Species 68-71 apolipoprotein E Mus musculus 114-118 18976655-4 2008 Of note, 2-week hyperhomocysteinemia (HHcy) ApoE(-/-) mice showed accelerated lesion formation and parallel lower Trx expression in macrophages than ApoE(-/-) mice, suggesting that HHcy-induced sustained oxidative stress in vivo might account for impaired Trx and hence increased ROS production and MCP-1 secretion from macrophages, and subsequently accelerated atherogenesis. Reactive Oxygen Species 280-283 apolipoprotein E Mus musculus 44-48 10737615-4 2000 Synaptosomal preparations from apoE KO and wild-type mice exhibited similar basal levels of reactive oxygen species, mitochondrial function, and caspase activity; however, following application of amyloid beta-peptide [Abeta(1-40)], apoE KO synaptosomes displayed increased levels of oxidative stress, mitochondrial dysfunction, and caspase activation compared with synaptosomes from wild-type mice. Reactive Oxygen Species 92-115 apolipoprotein E Mus musculus 31-35 17965457-2 2008 In the present study, protein carbonylation of BAT, consistent with modification by reactive oxygen species and their products, was increased in hepatic homogenates of apolipoprotein E knock-out mice. Reactive Oxygen Species 84-107 apolipoprotein E Mus musculus 168-184 17005918-6 2007 NCX 6550 also significantly reduced phorbol 12-myristate 13-acetate-induced ROS production that was enhanced in isolated ApoE-/- splenocytes. Reactive Oxygen Species 76-79 apolipoprotein E Mus musculus 121-125 17005918-7 2007 Conversely, pravastatin had no significant effects on adhesion in normal or ApoE-/- mice but reduced the enhanced ROS production from ApoE-/- splenocytes. Reactive Oxygen Species 114-117 apolipoprotein E Mus musculus 134-138 15264223-6 2004 Synaptosomes from APOE-knockout mice also had increased ROS, increased protein oxidation, and decreased mitochondrial membrane potential, but to a significantly lesser degree. Reactive Oxygen Species 56-59 apolipoprotein E Mus musculus 18-22 11922914-7 2002 ApoE-knockout mice with hyperhomocysteinemia (the level of plasma Hcy was 20.3+/-2.9 vs. 2.6+/-0.6 microM in control group, P<0.05) had a significant promotion of T-cell proliferation in response to Con A. Hcy (0.3-3.0 mM) also increased the intracellular ROS. Reactive Oxygen Species 259-262 apolipoprotein E Mus musculus 0-4 35493076-7 2022 In comparison with infected ApoE-/- mice, the level of ROS in atherosclerotic lesion in ApoE-/-TLR2-/- mice with C. pneumoniae infection decreased. Reactive Oxygen Species 55-58 apolipoprotein E Mus musculus 28-32 34869701-12 2021 The degree of mitochondrial dysfunction, reactive oxygen species production, vascular senescence, atherosclerosis, and the number of fragmented mitochondria accompanied by Drp1 activation were all higher in ApoE KO mice than in C57BL/6 mice. Reactive Oxygen Species 41-64 apolipoprotein E Mus musculus 207-211 35493076-7 2022 In comparison with infected ApoE-/- mice, the level of ROS in atherosclerotic lesion in ApoE-/-TLR2-/- mice with C. pneumoniae infection decreased. Reactive Oxygen Species 55-58 apolipoprotein E Mus musculus 88-92 31422047-6 2019 RESULTS: CLI associated with ApoE deficiency resulted in more severe mitochondrial dysfunction: maximum oxidative capacity and calcium retention capacity were decreased (-42.9% vs. -25.1%, p = .010; and -73.1% vs. -40.3%, p = .003 respectively) and production of reactive oxygen species was enhanced (+63.6% vs. +41.4%, p = .03) in ApoE-/- mice compared with ApoE+/+ mice respectively. Reactive Oxygen Species 263-286 apolipoprotein E Mus musculus 29-33 35016995-7 2022 There was also an increase in ROS production in the CNS of MVE-exposed ov- and ov + ApoE-/- mice. Reactive Oxygen Species 30-33 apolipoprotein E Mus musculus 84-88 35269673-10 2022 Therefore, we conclude that doxycycline in ApoE-/-/OVX animals promotes a reduction in atherosclerotic lesions by reducing ROS and MMP-2 activity and expression. Reactive Oxygen Species 123-126 apolipoprotein E Mus musculus 43-47 32533834-9 2021 Reactive oxygen species production was increased 2-fold in aortic arch perivascular fat of diabetic eET-1/Apoe-/- and eET-1/Apoe-/- / Nox4-/- mice but not eET-1/Apoe-/- / Nox1y/- mice. Reactive Oxygen Species 0-23 apolipoprotein E Mus musculus 106-110 32533834-9 2021 Reactive oxygen species production was increased 2-fold in aortic arch perivascular fat of diabetic eET-1/Apoe-/- and eET-1/Apoe-/- / Nox4-/- mice but not eET-1/Apoe-/- / Nox1y/- mice. Reactive Oxygen Species 0-23 apolipoprotein E Mus musculus 124-128 32533834-9 2021 Reactive oxygen species production was increased 2-fold in aortic arch perivascular fat of diabetic eET-1/Apoe-/- and eET-1/Apoe-/- / Nox4-/- mice but not eET-1/Apoe-/- / Nox1y/- mice. Reactive Oxygen Species 0-23 apolipoprotein E Mus musculus 124-128 32132319-6 2020 Chronic subcutaneous stimulation of TLR7 in apolipoprotein E-deficient (ApoE-/-) mice increased aortic production of reactive oxygen species (ROS), the number of circulating EMPs, and most importantly, augmented the formation of atherosclerotic plaque when compared with vehicle-treated animals.Systemic stimulation of TLR7 leads to impaired reendothelialization upon acute vascular injury and is associated with the production of pro-inflammatory cytokines and increased levels of circulating EMPs and Sca1/Flk1 positive cells. Reactive Oxygen Species 117-140 apolipoprotein E Mus musculus 72-76 32132319-6 2020 Chronic subcutaneous stimulation of TLR7 in apolipoprotein E-deficient (ApoE-/-) mice increased aortic production of reactive oxygen species (ROS), the number of circulating EMPs, and most importantly, augmented the formation of atherosclerotic plaque when compared with vehicle-treated animals.Systemic stimulation of TLR7 leads to impaired reendothelialization upon acute vascular injury and is associated with the production of pro-inflammatory cytokines and increased levels of circulating EMPs and Sca1/Flk1 positive cells. Reactive Oxygen Species 142-145 apolipoprotein E Mus musculus 72-76 32132319-7 2020 Importantly, ApoE-/- mice chronically treated with R848 displayed increased atherosclerotic plaque development and elevated levels of ROS in the aortic tissue. Reactive Oxygen Species 134-137 apolipoprotein E Mus musculus 13-17 31634818-9 2020 Treatment of ApoE-/- mice with SAHA reduced significantly the extent of atherosclerotic lesions, and the aortic expression of Nox subtypes, NADPH-stimulated ROS production, oxidative stress and pro-inflammatory markers. Reactive Oxygen Species 157-160 apolipoprotein E Mus musculus 13-17 30165101-6 2018 In vivo, high-fat fed, atherosclerotic Trail-/-Apoe-/- mice exhibited a significant impairment in endothelial-dependent vasorelaxation, which correlated with increased vascular ROS and 4-hydroxynonenal compared to Apoe-/- mice. Reactive Oxygen Species 177-180 apolipoprotein E Mus musculus 47-51 30342191-9 2018 Pharmacological inhibition of Nox2 decreased reactive oxygen species production and protein oxidative modifications in the muscle of ApoE-/- mice subjected to a Western-type diet. Reactive Oxygen Species 45-68 apolipoprotein E Mus musculus 133-137 29100334-5 2017 This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion. Reactive Oxygen Species 26-49 apolipoprotein E Mus musculus 62-66 29225168-6 2018 A significant increase in macrophage infiltration, excretion of inflammatory cytokines, activities and expression levels of MMP2 and MMP9, reactive oxygen species levels and cell apoptosis in aneurysmal aortic wall of Apoe-/- mice infused with Ang-II, and these events were significantly alleviated by co-treatment with cortistatin. Reactive Oxygen Species 139-162 apolipoprotein E Mus musculus 218-222 28970293-6 2017 Apolipoprotein E-deficient (ApoE-/-) mice showed decreased mtDNA integrity and mitochondrial respiration, associated with increased mitochondrial reactive oxygen species. Reactive Oxygen Species 146-169 apolipoprotein E Mus musculus 28-32 29079564-8 2017 Targeting mitochondrial reactive oxygen species with MitoTEMPO attenuated features of atherosclerotic plaque vulnerability in middle-aged Apoe-/-/Sod2+/- mice by lowering expression of calpain-2, caspase-3, and matrix metalloproteinase-2 and decreasing smooth muscle cell apoptosis and matrix degradation. Reactive Oxygen Species 24-47 apolipoprotein E Mus musculus 138-142 29100334-5 2017 This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion. Reactive Oxygen Species 51-54 apolipoprotein E Mus musculus 62-66 28177681-5 2017 ApoE-/- mice had significantly more atherosclerosis in the aortic root together with increased aortic ROS production, body mass, plasma triglyceride (TG) and total cholesterol (TC) concentration, decreased aortic eNOS expression, and plasma NO concentration. Reactive Oxygen Species 102-105 apolipoprotein E Mus musculus 0-4 25675483-7 2015 A potential mechanism by which ROS contribute to CAA pathogenesis is also identified because apocynin substantially reduces expression levels of ApoE-a factor known to promote CAA formation. Reactive Oxygen Species 31-34 apolipoprotein E Mus musculus 145-149 26751387-6 2016 Chronic TLR9 agonism in apolipoprotein E-deficient (ApoE-/-) mice fed a cholesterol-rich diet increased aortic production of reactive oxygen species, the number of circulating endothelial microparticles, circulating sca-1/flk-1 positive cells, and most importantly augmented atherosclerotic plaque formation when compared to vehicle treated animals. Reactive Oxygen Species 125-148 apolipoprotein E Mus musculus 52-56 26054376-2 2015 We and others demonstrated that NOX1/2 NADPH oxidase inhibition, by genetic deletion of p47phox, in Apoe(-/-) mice decreases vascular reactive oxygen species (ROS) generation and atherosclerosis in young age. Reactive Oxygen Species 134-157 apolipoprotein E Mus musculus 100-104 26054376-2 2015 We and others demonstrated that NOX1/2 NADPH oxidase inhibition, by genetic deletion of p47phox, in Apoe(-/-) mice decreases vascular reactive oxygen species (ROS) generation and atherosclerosis in young age. Reactive Oxygen Species 159-162 apolipoprotein E Mus musculus 100-104 25860063-7 2015 The atherosclerotic lesions and the imbalance of NO/ROS were reduced (40%) in apoE-sil mice. Reactive Oxygen Species 52-55 apolipoprotein E Mus musculus 78-82 25496431-7 2015 Vascular ROS levels were also elevated by twofold in NOX1(-/y)/APOE(-/-) versus APOE(-/-) mice (P < 0.05), despite no changes in expression of other NOX subunits. Reactive Oxygen Species 9-12 apolipoprotein E Mus musculus 63-67 25496431-7 2015 Vascular ROS levels were also elevated by twofold in NOX1(-/y)/APOE(-/-) versus APOE(-/-) mice (P < 0.05), despite no changes in expression of other NOX subunits. Reactive Oxygen Species 9-12 apolipoprotein E Mus musculus 80-84 25860063-4 2015 The apoE-veh mice exhibited an imbalance of nitric oxide and reactive oxygen species (NO/ROS) levels and an increased maximum response (Rmax, 20%) and sensitivity (7%) to PE, which were not modified by endothelial removal. Reactive Oxygen Species 61-84 apolipoprotein E Mus musculus 4-8 25860063-4 2015 The apoE-veh mice exhibited an imbalance of nitric oxide and reactive oxygen species (NO/ROS) levels and an increased maximum response (Rmax, 20%) and sensitivity (7%) to PE, which were not modified by endothelial removal. Reactive Oxygen Species 89-92 apolipoprotein E Mus musculus 4-8 24511132-4 2014 Here we show that Nox4 is the main source of renal ROS in a mouse model of diabetic nephropathy induced by streptozotocin administration in ApoE(-/-) mice. Reactive Oxygen Species 51-54 apolipoprotein E Mus musculus 140-144 23887640-8 2013 Reactive oxygen species production was increased >= 2-fold in perivascular fat, media, or atherosclerotic lesions in the ascending aorta and AAAs of eET-1/Apoe(-/-) compared with Apoe(-/-) (P<0.05). Reactive Oxygen Species 0-23 apolipoprotein E Mus musculus 158-162 25164224-11 2014 Thoracic aorta gp91(phox) protein level and ROS level in blood and thoracic aorta homogenates were lower in STZ+apoE(-/-)+Bex 10 group than in STZ+apoE(-/-) group (P < 0.05). Reactive Oxygen Species 44-47 apolipoprotein E Mus musculus 112-116 24612630-13 2014 Moreover, pharmacological arginase inhibition by NOHA attenuated the augmented ROS production within the corpus cavernosum of ApoE(-/-) mice, which increased the NO-dependent response in cavernosal strips. Reactive Oxygen Species 79-82 apolipoprotein E Mus musculus 126-130 24292634-7 2014 Diabetic Apoe(-/-) mice demonstrated an elevation in vascular ROS production and expression of the proinflammatory markers monocyte chemoattractant protein 1, vascular adhesion molecule 1 and IFNgamma. Reactive Oxygen Species 62-65 apolipoprotein E Mus musculus 9-13 24292634-11 2014 Blockade of NOX-derived ROS using the NOX inhibitor GKT137831 is associated with attenuation of these changes in the immune response and reduces the diabetes-accelerated development of atherosclerotic plaques in Apoe(-/-) mice. Reactive Oxygen Species 24-27 apolipoprotein E Mus musculus 212-216 24191281-6 2014 This apoE(-/-)-specific response is attributed to reactive oxygen species-mediated p38 mitogen-activated protein kinase activation and subsequent phosphorylation of myosin light chain (MLC(20)), causing renal vasoconstriction. Reactive Oxygen Species 50-73 apolipoprotein E Mus musculus 5-9 24191281-11 2014 In summary, Ang-(1-7) modulates vascular function via Mas-receptor activation that attenuates pressor response to Ang II in apoE(-/-) mice by reducing reactive oxygen species-mediated p38 mitogen-activated protein kinase activity. Reactive Oxygen Species 151-174 apolipoprotein E Mus musculus 124-128 23887640-8 2013 Reactive oxygen species production was increased >= 2-fold in perivascular fat, media, or atherosclerotic lesions in the ascending aorta and AAAs of eET-1/Apoe(-/-) compared with Apoe(-/-) (P<0.05). Reactive Oxygen Species 0-23 apolipoprotein E Mus musculus 182-186 22547655-4 2012 METHODS AND RESULTS: Treatment of ApoE(-/-) mice with 17-DMAG (2 mg/kg every 2 days for 10 weeks) decreased ROS levels and extracellular signal-regulated kinase (ERK) activation in aortic plaques compared with control animals. Reactive Oxygen Species 108-111 apolipoprotein E Mus musculus 34-38 23415688-11 2013 BRCA1-overexpressing ApoE(-/-) mice fed a Western diet developed significantly less aortic plaque lesions, exhibited reduced macrophage infiltration, and generated less reactive oxygen species. Reactive Oxygen Species 169-192 apolipoprotein E Mus musculus 21-25 24045154-5 2013 Consistent with these observations, we found that peritoneal macrophages from apolipoprotein E-deficient (ApoE-/-) mice fed a high-fat diet (a mouse model of atherosclerosis) exhibited increased xanthine oxidase and NADPH oxidase activities; ROS production; phosphorylation of Syk, Pyk2, MAPK, and CREB; and IL-17A production compared to those from similarly fed ApoE-/-:12/15-LO-/- mice. Reactive Oxygen Species 242-245 apolipoprotein E Mus musculus 106-110 23385237-4 2013 The production of both superoxide and hydrogen peroxide in bone marrow cells was higher in young apoE-/- mice than in age-matched C57 mice, and reactive oxygen species were increased in aged C57 and apoE-/- mice. Reactive Oxygen Species 144-167 apolipoprotein E Mus musculus 200-204 22401921-10 2012 CONCLUSIONS: The short-term effects of (56)Fe irradiation on hippocampal ROS levels and hippocampus-dependent spatial memory retention are apoE isoform-dependent. Reactive Oxygen Species 73-76 apolipoprotein E Mus musculus 139-143 22253482-5 2012 By contrast, ApoE(-/-)/TLR4(mut) mice lacking functional TLR4 were resistant to HFHC diet-induced liver inflammation and injury and were less susceptible to the diet-induced production of reactive oxygen species (ROS) and proinflammatory cytokines. Reactive Oxygen Species 188-211 apolipoprotein E Mus musculus 13-17 22253482-5 2012 By contrast, ApoE(-/-)/TLR4(mut) mice lacking functional TLR4 were resistant to HFHC diet-induced liver inflammation and injury and were less susceptible to the diet-induced production of reactive oxygen species (ROS) and proinflammatory cytokines. Reactive Oxygen Species 213-216 apolipoprotein E Mus musculus 13-17 22282402-2 2012 Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Reactive Oxygen Species 63-86 apolipoprotein E Mus musculus 107-111 22282402-2 2012 Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Reactive Oxygen Species 88-91 apolipoprotein E Mus musculus 107-111 22613987-8 2012 After PNS administration for 4 weeks, the apoE(-/-) mice displayed reduced level of serum MDA and enhanced activity of SOD and GSH, accompanied by impaired ROS generation in the aortic root. Reactive Oxygen Species 156-159 apolipoprotein E Mus musculus 42-46 22814241-8 2012 RESULTS: Decreased insulin content and increased apoptosis and ROS production were found in pancreatic islets of apoE(-/-)mice, accompanied by elevated plasma LDL. Reactive Oxygen Species 63-66 apolipoprotein E Mus musculus 113-117 21884703-7 2011 ApoE -/- mice treated with the selective CB2 agonist JWH 133 during a high-cholesterol diet showed decreased atherosclerotic lesion formation, improved endothelial function and reduced levels of reactive oxygen species. Reactive Oxygen Species 195-218 apolipoprotein E Mus musculus 0-4 21330604-2 2011 We recently demonstrated that CyPA increased angiotensin II (Ang II)-induced reactive oxygen species (ROS) production in the aortas of apolipoprotein E (Apoe)-/- mice. Reactive Oxygen Species 77-100 apolipoprotein E Mus musculus 135-151 21330604-2 2011 We recently demonstrated that CyPA increased angiotensin II (Ang II)-induced reactive oxygen species (ROS) production in the aortas of apolipoprotein E (Apoe)-/- mice. Reactive Oxygen Species 102-105 apolipoprotein E Mus musculus 135-151 21330604-2 2011 We recently demonstrated that CyPA increased angiotensin II (Ang II)-induced reactive oxygen species (ROS) production in the aortas of apolipoprotein E (Apoe)-/- mice. Reactive Oxygen Species 102-105 apolipoprotein E Mus musculus 153-157 21330604-8 2011 Ang II-induced ROS production, cardiac fibroblast proliferation, and cardiac fibroblast migration were markedly decreased in Apoe-/-Ppia-/- cardiac fibroblasts. Reactive Oxygen Species 15-18 apolipoprotein E Mus musculus 125-129 21873804-8 2011 RESULTS: ApoE(-/-) mice administrated with NAC displayed reduced serum MDA level and impaired ROS generation in aortic root. Reactive Oxygen Species 94-97 apolipoprotein E Mus musculus 9-13