PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20557081-11	2010	Taken together, our results provide the first evidence of the activation of the ROS-dependent cofilin- and Bax-triggered mitochondrial pathway as a critical mechanism of MAA-induced cell death in liver cancer cells.	Reactive Oxygen Species	80-83	cofilin 1	Homo sapiens	94-101	
23982146-7	2013	These data indicate that RanBP9, cofilin, and Abeta mimic and potentiate each other to produce mitochondrial dysfunction, ROS overproduction, and calcium deregulation, which leads to neurodegenerative changes reminiscent of those seen in AD.	Reactive Oxygen Species	122-125	cofilin 1	Homo sapiens	33-40	
20446771-4	2010	We found that scavenging of ROS produced by mitochondria activated the Rho/ROCK/LIMK signaling pathway that was followed by phosphorylation of cofilin and stabilization of actin stress fibers.	Reactive Oxygen Species	28-31	cofilin 1	Homo sapiens	143-150	
23695982-9	2013	Pretreatment with a thiol-containing reactive oxygen species (ROS) scavenger N-acetyl cysteine, but not other ROS inhibitors without thiol groups, suppressed CuB-induced actin aggregation, cofilin hyperactivation and cofilin-actin rod formation, suggesting that thiol oxidation might be involved in these processes.	Reactive Oxygen Species	37-60	cofilin 1	Homo sapiens	189-196	
23695982-9	2013	Pretreatment with a thiol-containing reactive oxygen species (ROS) scavenger N-acetyl cysteine, but not other ROS inhibitors without thiol groups, suppressed CuB-induced actin aggregation, cofilin hyperactivation and cofilin-actin rod formation, suggesting that thiol oxidation might be involved in these processes.	Reactive Oxygen Species	62-65	cofilin 1	Homo sapiens	189-196	
23695982-9	2013	Pretreatment with a thiol-containing reactive oxygen species (ROS) scavenger N-acetyl cysteine, but not other ROS inhibitors without thiol groups, suppressed CuB-induced actin aggregation, cofilin hyperactivation and cofilin-actin rod formation, suggesting that thiol oxidation might be involved in these processes.	Reactive Oxygen Species	62-65	cofilin 1	Homo sapiens	217-224	
21302299-7	2011	These findings indicate that NRG-induced HaCaT cell migration via the ROS-SSH-1L-cofilin pathway is activated as a consequence of Rac1 and Nox activation.	Reactive Oxygen Species	70-73	cofilin 1	Homo sapiens	81-88	
19339277-0	2009	Reactive oxygen species regulate a slingshot-cofilin activation pathway.	Reactive Oxygen Species	0-23	cofilin 1	Homo sapiens	45-52	
19339277-5	2009	The ROS-dependent activation of the SSH-1L-cofilin pathway stimulates the SSH-1L-dependent formation of cofilin-actin rods in cofilin-GFP-expressing HeLa cells.	Reactive Oxygen Species	4-7	cofilin 1	Homo sapiens	43-50	
19339277-5	2009	The ROS-dependent activation of the SSH-1L-cofilin pathway stimulates the SSH-1L-dependent formation of cofilin-actin rods in cofilin-GFP-expressing HeLa cells.	Reactive Oxygen Species	4-7	cofilin 1	Homo sapiens	104-111	
19339277-5	2009	The ROS-dependent activation of the SSH-1L-cofilin pathway stimulates the SSH-1L-dependent formation of cofilin-actin rods in cofilin-GFP-expressing HeLa cells.	Reactive Oxygen Species	4-7	cofilin 1	Homo sapiens	104-111	
19339277-6	2009	Similarly, the formation of endogenous ROS stimulated by angiotensin II (AngII) also activates the SSH-1L-cofilin pathway via oxidation of 14-3-3zeta to increase AngII-induced membrane ruffling and cell motility.	Reactive Oxygen Species	39-42	cofilin 1	Homo sapiens	106-113	
19339277-7	2009	These results suggest that the formation of ROS by NADPH oxidases engages a SSH-1L-cofilin pathway to regulate cytoskeletal organization and cell migration.	Reactive Oxygen Species	44-47	cofilin 1	Homo sapiens	83-90	
34639067-7	2021	Cofilin functions are also modulated by various binding partners or reactive oxygen species.	Reactive Oxygen Species	68-91	cofilin 1	Homo sapiens	0-7