PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32648168-2	2022	During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS production.	Reactive Oxygen Species	114-117	aminoadipate-semialdehyde synthase	Mus musculus	77-100	
33666092-4	2021	Current evidence suggests that elevated ROS production in ischemic tissues occurs due to accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion.	Reactive Oxygen Species	40-43	aminoadipate-semialdehyde synthase	Mus musculus	164-187	
33666092-4	2021	Current evidence suggests that elevated ROS production in ischemic tissues occurs due to accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion.	Reactive Oxygen Species	40-43	aminoadipate-semialdehyde synthase	Mus musculus	189-192	
32648168-2	2022	During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS production.	Reactive Oxygen Species	114-117	aminoadipate-semialdehyde synthase	Mus musculus	102-105	
25874444-0	2015	Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells.	Reactive Oxygen Species	96-99	aminoadipate-semialdehyde synthase	Mus musculus	14-37	
25874444-11	2015	CONCLUSIONS/INTERPRETATION: SDH is an important regulator of insulin secretion and ROS production.	Reactive Oxygen Species	83-86	aminoadipate-semialdehyde synthase	Mus musculus	28-31	
27667687-3	2016	We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production.	Reactive Oxygen Species	178-201	aminoadipate-semialdehyde synthase	Mus musculus	64-87	
27667687-3	2016	We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production.	Reactive Oxygen Species	178-201	aminoadipate-semialdehyde synthase	Mus musculus	89-92	
27667687-3	2016	We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production.	Reactive Oxygen Species	203-206	aminoadipate-semialdehyde synthase	Mus musculus	64-87	
27667687-3	2016	We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production.	Reactive Oxygen Species	203-206	aminoadipate-semialdehyde synthase	Mus musculus	89-92	
18372923-8	2008	We propose that alpha-TOS displaces UbQ in CII causing electrons generated by SDH to recombine with molecular oxygen to yield ROS.	Reactive Oxygen Species	126-129	aminoadipate-semialdehyde synthase	Mus musculus	78-81	
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	177-200	aminoadipate-semialdehyde synthase	Mus musculus	36-59	
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	177-200	aminoadipate-semialdehyde synthase	Mus musculus	61-64	
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	202-205	aminoadipate-semialdehyde synthase	Mus musculus	36-59	
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	202-205	aminoadipate-semialdehyde synthase	Mus musculus	61-64