PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19409565-1 2009 The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis. Reactive Oxygen Species 98-121 prohibitin 2 Mus musculus 65-68 25308545-4 2014 We aimed to better understand (i) the strengths and weaknesses of the two methods applied in blood and their potential to predict germ cell mutagenicity, and (ii) the involvement of reactive oxygen species (ROS) following in vivo BaP-exposure. Reactive Oxygen Species 182-205 prohibitin 2 Mus musculus 230-233 25308545-4 2014 We aimed to better understand (i) the strengths and weaknesses of the two methods applied in blood and their potential to predict germ cell mutagenicity, and (ii) the involvement of reactive oxygen species (ROS) following in vivo BaP-exposure. Reactive Oxygen Species 207-210 prohibitin 2 Mus musculus 230-233 25308545-5 2014 To explore the involvement of ROS on BaP genotoxicity, we utilised a mouse model deficient in a DNA glycosylase. Reactive Oxygen Species 30-33 prohibitin 2 Mus musculus 37-40 19409565-1 2009 The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis. Reactive Oxygen Species 123-126 prohibitin 2 Mus musculus 65-68 19409565-2 2009 To assess the causal role of BaP-generated ROS in this process, we evaluated atherosclerotic metrics in apolipoprotein E-deficient (ApoE(-/-)) mice with or without overexpression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and/or catalase. Reactive Oxygen Species 43-46 prohibitin 2 Mus musculus 29-32 19409565-8 2009 These observations, together with the functions of catalase and Cu/Zn-SOD to scavenge hydrogen peroxide and superoxide anions, implicate a causal role of ROS in the pathogenesis of BaP-induced atherosclerosis. Reactive Oxygen Species 154-157 prohibitin 2 Mus musculus 181-184