PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18483560-11	2008	CYP1B1 Val432 was estimated to generate higher ROS in RPE cells compared to its allelic variant (Leu432; p=0.0245 for 15 min and p=0.0197 for 30 min).	Reactive Oxygen Species	47-50	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
18483560-14	2008	Higher ROS generation by Val432 in CYP1B1 might lead to apoptotic change that leads to glaucoma.	Reactive Oxygen Species	7-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	35-41	
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Reactive Oxygen Species	281-284	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-144	
33185690-5	2020	A growing body of evidence is demonstrating a detrimental role of CYP1B1 in both cardiovascular diseases and cancer, via perturbed metabolism of endogenous compounds, production of carcinogenic metabolites, DNA adduct formation, and generation of reactive oxygen species (ROS).	Reactive Oxygen Species	247-270	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
33185690-5	2020	A growing body of evidence is demonstrating a detrimental role of CYP1B1 in both cardiovascular diseases and cancer, via perturbed metabolism of endogenous compounds, production of carcinogenic metabolites, DNA adduct formation, and generation of reactive oxygen species (ROS).	Reactive Oxygen Species	272-275	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
33185690-6	2020	Several chemotherapeutic agents have been shown to induce CYP1B1 in cardiovascular and cancer cells, possibly via activating the Aryl hydrocarbon Receptor (AhR), ROS generation, and inflammatory cytokines.	Reactive Oxygen Species	162-165	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	58-64	
31382511-0	2019	Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1.	Reactive Oxygen Species	54-77	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	93-99	
31382511-7	2019	Notably, the pro-angiogenic response of IS and increased ROS production were abolished when CYP1B1, one of the main target genes that was highly upregulated by IS, was silenced.	Reactive Oxygen Species	57-60	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	92-98	
31382511-8	2019	This observation indicates IS-induced ROS in endothelial cells is CYP1B1-dependent.	Reactive Oxygen Species	38-41	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
18583386-0	2008	Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls.	Reactive Oxygen Species	0-23	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	53-72	
15142886-6	2004	Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling.	Reactive Oxygen Species	323-326	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40