PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24287819-12 2014 DAT and MAO-A/B, which are expressed by GCs, are prerequisites for a DA receptor-independent generation of ROS in GCs. Reactive Oxygen Species 107-110 monoamine oxidase A Homo sapiens 8-15 24287819-13 2014 Blockers of DAT and MAO-A/B, as well as an antioxidant, prevented the generation of ROS (P < 0.05). Reactive Oxygen Species 84-87 monoamine oxidase A Homo sapiens 20-27 24287819-17 2014 In PCOS-derived follicular fluid, the levels of DA were higher (P < 0.05) in GCs, the transcript levels of DAT and MAO-A/B in GCs were 2-fold higher (P < 0.05) and the DA-induced ROS levels were found to be more than 4-fold increased (P < 0.05) compared with non-PCOS cells. Reactive Oxygen Species 185-188 monoamine oxidase A Homo sapiens 118-125 34607159-9 2021 MAO-A activation-impaired mitochondrial homeostasis resulted in ROS accumulation and NF-kappaB activation, thereby enhancing expression of atherogenic and proinflammatory molecules in ECs. Reactive Oxygen Species 64-67 monoamine oxidase A Homo sapiens 0-5 17561096-0 2007 MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Reactive Oxygen Species 49-72 monoamine oxidase A Homo sapiens 0-5 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Reactive Oxygen Species 76-99 monoamine oxidase A Homo sapiens 38-57 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Reactive Oxygen Species 76-99 monoamine oxidase A Homo sapiens 59-64 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Reactive Oxygen Species 101-104 monoamine oxidase A Homo sapiens 38-57 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Reactive Oxygen Species 101-104 monoamine oxidase A Homo sapiens 59-64 17561096-2 2007 This study aimed to investigate the role of ROS in the mitogenic signaling activated during tyramine and serotonin oxidation by MAO-A in smooth muscle cells (SMC). Reactive Oxygen Species 44-47 monoamine oxidase A Homo sapiens 128-133 23124025-10 2013 As evidence of differential regulation of gene function by IL-4 and IL-13, we further report that MAO-A-mediated reactive oxygen species generation is influenced by different Jaks. Reactive Oxygen Species 113-136 monoamine oxidase A Homo sapiens 98-103 17883400-10 2007 Therefore our data provide evidence that MAO-A, through its production of reactive oxygen species as a by-product of its catalytic activity on the mitochondrial surface, is recruited by the cell to enhance apoptotic signalling. Reactive Oxygen Species 74-97 monoamine oxidase A Homo sapiens 41-46 17561096-4 2007 Silencing MAO-A by siRNA, pharmacological MAO-A inhibitors (pargyline and Ro41-1049), and the antioxidant/ROS scavenger butylated hydroxytoluene (BHT) inhibited the signaling cascade, suggesting that ROS generated during tyramine oxidation by MAO-A are required. Reactive Oxygen Species 200-203 monoamine oxidase A Homo sapiens 10-15 31243972-8 2019 Highlights are given on how new specific recognition moieties of tyrosinase and MAO-A were designed to eliminate the interference by reactive oxygen species (ROS) and MAO-B, respectively. Reactive Oxygen Species 133-156 monoamine oxidase A Homo sapiens 80-85 35566238-2 2022 Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen species (ROS) that trigger DNA damage and oxidative injury of cells resulting in tumor initiation and progression. Reactive Oxygen Species 62-85 monoamine oxidase A Homo sapiens 0-19 35566238-2 2022 Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen species (ROS) that trigger DNA damage and oxidative injury of cells resulting in tumor initiation and progression. Reactive Oxygen Species 62-85 monoamine oxidase A Homo sapiens 21-26 35566238-2 2022 Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen species (ROS) that trigger DNA damage and oxidative injury of cells resulting in tumor initiation and progression. Reactive Oxygen Species 87-90 monoamine oxidase A Homo sapiens 0-19 35566238-2 2022 Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen species (ROS) that trigger DNA damage and oxidative injury of cells resulting in tumor initiation and progression. Reactive Oxygen Species 87-90 monoamine oxidase A Homo sapiens 21-26 35202708-4 2022 Suppression of 5DS with the 5-HT2A receptor antagonist, MAO-A inhibitor, or gene silencing MAO-A significantly reduced the CCl4-induced production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species 164-187 monoamine oxidase A Homo sapiens 56-61 35202708-4 2022 Suppression of 5DS with the 5-HT2A receptor antagonist, MAO-A inhibitor, or gene silencing MAO-A significantly reduced the CCl4-induced production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species 164-187 monoamine oxidase A Homo sapiens 91-96 35202708-4 2022 Suppression of 5DS with the 5-HT2A receptor antagonist, MAO-A inhibitor, or gene silencing MAO-A significantly reduced the CCl4-induced production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species 189-192 monoamine oxidase A Homo sapiens 56-61 35202708-4 2022 Suppression of 5DS with the 5-HT2A receptor antagonist, MAO-A inhibitor, or gene silencing MAO-A significantly reduced the CCl4-induced production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species 189-192 monoamine oxidase A Homo sapiens 91-96 31051081-8 2019 Incubation of the adipose tissue samples and vascular rings with the MAO-A inhibitor (clorgyline, 30 min) improved vascular reactivity and decreased ROS generation. Reactive Oxygen Species 149-152 monoamine oxidase A Homo sapiens 69-74 31243972-8 2019 Highlights are given on how new specific recognition moieties of tyrosinase and MAO-A were designed to eliminate the interference by reactive oxygen species (ROS) and MAO-B, respectively. Reactive Oxygen Species 158-161 monoamine oxidase A Homo sapiens 80-85 30336354-4 2019 However, the downstream effects of MAO-A mediated ROS production in a neuronal model has not been previously investigated. Reactive Oxygen Species 50-53 monoamine oxidase A Homo sapiens 35-40 31680079-2 2019 Recently, it has been studied that MAO-A have a role in the cancer progression by elevating the generation of Reactive oxygen species (ROS) and by promoting epithelial to mesenchymal transition (EMT) through activation of Vascular endothelial growth factor (VEGF) and its co-receptor neuropilin-1. Reactive Oxygen Species 110-133 monoamine oxidase A Homo sapiens 35-40 31680079-2 2019 Recently, it has been studied that MAO-A have a role in the cancer progression by elevating the generation of Reactive oxygen species (ROS) and by promoting epithelial to mesenchymal transition (EMT) through activation of Vascular endothelial growth factor (VEGF) and its co-receptor neuropilin-1. Reactive Oxygen Species 135-138 monoamine oxidase A Homo sapiens 35-40 30336354-5 2019 In this study, using MAO-A overexpressing neuroblastoma cells, we demonstrate that higher levels of MAO-A protein/activity results in increased basal ROS levels with associated increase in protein oxidation. Reactive Oxygen Species 150-153 monoamine oxidase A Homo sapiens 21-26 30336354-5 2019 In this study, using MAO-A overexpressing neuroblastoma cells, we demonstrate that higher levels of MAO-A protein/activity results in increased basal ROS levels with associated increase in protein oxidation. Reactive Oxygen Species 150-153 monoamine oxidase A Homo sapiens 100-105 30336354-7 2019 Furthermore, ROS generated locally on the mitochondrial outer membrane by MAO-A promotes phosphorylation of dynamin-1-like protein, leading to mitochondrial fragmentation and clearance without complete loss of mitochondrial membrane potential. Reactive Oxygen Species 13-16 monoamine oxidase A Homo sapiens 74-79 30336354-10 2019 This study shows for the first time that MAO-A generated ROS is involved in quality control signalling, and increase in MAO-A protein levels leads to a protective cellular response in order to mediate removal of damaged macromolecules/organelles, but substrate availability may ultimately determine cell fate. Reactive Oxygen Species 57-60 monoamine oxidase A Homo sapiens 41-46 28044091-9 2016 These data suggest a close association between MAO-A-dependent ROS generation, actin oxidation, and ventricular dysfunction. Reactive Oxygen Species 63-66 monoamine oxidase A Homo sapiens 47-52 28402333-7 2017 Reactive oxygen species (ROS) produced by overexpressed MAOA plays an essential role in inhibiting apoptosis and activating autophagy in NED PCa cells. Reactive Oxygen Species 0-23 monoamine oxidase A Homo sapiens 56-60 28402333-7 2017 Reactive oxygen species (ROS) produced by overexpressed MAOA plays an essential role in inhibiting apoptosis and activating autophagy in NED PCa cells. Reactive Oxygen Species 25-28 monoamine oxidase A Homo sapiens 56-60 26871599-3 2016 Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. Reactive Oxygen Species 78-101 monoamine oxidase A Homo sapiens 0-19 26871599-3 2016 Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. Reactive Oxygen Species 78-101 monoamine oxidase A Homo sapiens 21-26 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Reactive Oxygen Species 77-80 monoamine oxidase A Homo sapiens 25-44 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Reactive Oxygen Species 77-80 monoamine oxidase A Homo sapiens 46-51 30003648-6 2018 Using cardiomyoblasts and primary cardiomyocytes, we demonstrate that chronic MAO-A activation mediated by synthetic (tyramine) and physiological (NE) substrates induces ROS-dependent DNA damage response, activation of cyclin-dependent kinase inhibitors p21cip , p16ink4a , and p15ink4b and typical features of senescence such as cell flattening and SA-beta-gal activity. Reactive Oxygen Species 170-173 monoamine oxidase A Homo sapiens 78-83 30003648-7 2018 Moreover, we observe that ROS produced by MAO-A lead to the accumulation of p53 in the cytosol where it inhibits parkin, an important regulator of mitophagy, resulting in mitochondrial dysfunction. Reactive Oxygen Species 26-29 monoamine oxidase A Homo sapiens 42-47 28546851-6 2017 MAOs" expression substantially increases with ageing (6-fold MAO-A in the heart and 4-fold MAO-B in neuronal tissue), and their involvement in cardiac diseases is supposedly related to the formation of ROS, via the hydrogen peroxide produced during the substrate degradation. Reactive Oxygen Species 202-205 monoamine oxidase A Homo sapiens 61-66 26499200-4 2015 In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Reactive Oxygen Species 238-261 monoamine oxidase A Homo sapiens 95-114 26499200-4 2015 In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Reactive Oxygen Species 263-266 monoamine oxidase A Homo sapiens 95-114 25585152-4 2015 MAOA induces epithelial-mesenchymal transition (EMT) and augments hypoxic effects by producing excess reactive oxygen species. Reactive Oxygen Species 102-125 monoamine oxidase A Homo sapiens 0-4 25198178-7 2014 MAOA activity increased the levels of reactive oxygen species and increased the expression and nuclear translocation of HIF1alpha. Reactive Oxygen Species 38-61 monoamine oxidase A Homo sapiens 0-4