PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21963990-2	2011	The P450 catalytic cycle is known to uncouple and release reactive oxygen species (ROS), but the effects of ROS from P450 and other enzymes in the endoplasmic reticulum have been poorly studied from the perspective of effects on cell biology.	Reactive Oxygen Species	58-81	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-8	
21913995-11	2012	Toxicity by CYP2B6 was abolished with the reactive oxygen species scavenger N-acetylcysteine.	Reactive Oxygen Species	42-65	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	12-18	
21963990-2	2011	The P450 catalytic cycle is known to uncouple and release reactive oxygen species (ROS), but the effects of ROS from P450 and other enzymes in the endoplasmic reticulum have been poorly studied from the perspective of effects on cell biology.	Reactive Oxygen Species	83-86	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-8	
20735006-4	2010	Here we show that electrochemical generation of reactive oxygen species (ROS), a process reminiscent of the catalytic cycle of P450, extends the applicability of electrochemistry in drug metabolism research.	Reactive Oxygen Species	48-71	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	127-131	
20735006-4	2010	Here we show that electrochemical generation of reactive oxygen species (ROS), a process reminiscent of the catalytic cycle of P450, extends the applicability of electrochemistry in drug metabolism research.	Reactive Oxygen Species	73-76	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	127-131	
16608165-0	2006	Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction.	Reactive Oxygen Species	103-126	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	152-156	
16956955-7	2006	Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species.	Reactive Oxygen Species	272-295	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	100-104	
16608165-12	2006	Our present findings indicate that the oxidase activity of P450 (i.e., formation of ROS) represents a mechanism of deboronation.	Reactive Oxygen Species	84-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	59-63	
18976212-6	2008	Under some conditions, cytochromes P450 can produce reactive oxygen species, and this is another problem attracting increasing attention.	Reactive Oxygen Species	52-75	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	35-39	
16608165-7	2006	Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2.	Reactive Oxygen Species	21-44	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	97-101	
16608165-7	2006	Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2.	Reactive Oxygen Species	46-49	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	97-101	
16608165-9	2006	The presence of superoxide dismutase (SOD) and catalase prevented the deboronation of 1, thus, supporting the involvement of ROS in the P450 2E1-catalyzed deboronation reaction.	Reactive Oxygen Species	125-128	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	136-140	
10945868-10	2000	The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease.	Reactive Oxygen Species	214-237	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58	
10945868-10	2000	The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease.	Reactive Oxygen Species	214-237	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	177-181