PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21963990-2 2011 The P450 catalytic cycle is known to uncouple and release reactive oxygen species (ROS), but the effects of ROS from P450 and other enzymes in the endoplasmic reticulum have been poorly studied from the perspective of effects on cell biology. Reactive Oxygen Species 58-81 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 4-8 21913995-11 2012 Toxicity by CYP2B6 was abolished with the reactive oxygen species scavenger N-acetylcysteine. Reactive Oxygen Species 42-65 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 12-18 21963990-2 2011 The P450 catalytic cycle is known to uncouple and release reactive oxygen species (ROS), but the effects of ROS from P450 and other enzymes in the endoplasmic reticulum have been poorly studied from the perspective of effects on cell biology. Reactive Oxygen Species 83-86 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 4-8 20735006-4 2010 Here we show that electrochemical generation of reactive oxygen species (ROS), a process reminiscent of the catalytic cycle of P450, extends the applicability of electrochemistry in drug metabolism research. Reactive Oxygen Species 48-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 127-131 20735006-4 2010 Here we show that electrochemical generation of reactive oxygen species (ROS), a process reminiscent of the catalytic cycle of P450, extends the applicability of electrochemistry in drug metabolism research. Reactive Oxygen Species 73-76 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 127-131 16608165-0 2006 Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction. Reactive Oxygen Species 103-126 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 152-156 16956955-7 2006 Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species. Reactive Oxygen Species 272-295 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 100-104 16608165-12 2006 Our present findings indicate that the oxidase activity of P450 (i.e., formation of ROS) represents a mechanism of deboronation. Reactive Oxygen Species 84-87 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 59-63 18976212-6 2008 Under some conditions, cytochromes P450 can produce reactive oxygen species, and this is another problem attracting increasing attention. Reactive Oxygen Species 52-75 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 35-39 16608165-7 2006 Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2. Reactive Oxygen Species 21-44 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-101 16608165-7 2006 Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2. Reactive Oxygen Species 46-49 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-101 16608165-9 2006 The presence of superoxide dismutase (SOD) and catalase prevented the deboronation of 1, thus, supporting the involvement of ROS in the P450 2E1-catalyzed deboronation reaction. Reactive Oxygen Species 125-128 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 136-140 10945868-10 2000 The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease. Reactive Oxygen Species 214-237 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 54-58 10945868-10 2000 The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease. Reactive Oxygen Species 214-237 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 177-181