PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27932512-8 2017 Many of the proteins encoded by the ATF6-induced oxidative stress genes identified here reside outside the ER, including catalase, which is known to decrease damaging reactive oxygen species in the heart. Reactive Oxygen Species 167-190 catalase Mus musculus 121-129 26918394-2 2016 We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Reactive Oxygen Species 75-78 catalase Mus musculus 147-150 28253986-9 2017 As ROS has been increasingly recognized as essential signaling molecules that may be beneficial in hormesis, stress response and immunity, the potential pleiotropic, or adverse effects of mCAT are also discussed. Reactive Oxygen Species 3-6 catalase Mus musculus 188-192 27465136-7 2016 Treatment with the pro-oxidant SIN-10 increased ROS in spermatocytes of aged wild-type and Sod(-/-) mice, while aged Cat(-/-) mice were able to neutralize this ROS. Reactive Oxygen Species 160-163 catalase Mus musculus 117-120 27160095-8 2016 Inhibition of CAT activity increased endogenous ROS levels, but did not perturb meiotic maturation. Reactive Oxygen Species 48-51 catalase Mus musculus 14-17 27160095-10 2016 Therefore, our data suggest that CAT is required not only to scavenge ROS, but also to protect DNA from oxidative damage during meiotic maturation in mouse oocytes. Reactive Oxygen Species 70-73 catalase Mus musculus 33-36 27061426-2 2016 We have previously shown that transgenic expression of the antioxidant enzyme catalase targeted to the mitochondria (mCAT) in mice reduces ROS, attenuates age-related disease, and increases lifespan. Reactive Oxygen Species 139-142 catalase Mus musculus 117-121 27061426-4 2016 We therefore hypothesized that mCAT might be beneficial only when ROS approaches pathological levels in older age and might not be advantageous at a younger age when basal ROS is low. Reactive Oxygen Species 66-69 catalase Mus musculus 31-35 31289615-8 2019 Proteins involved in detoxification of reactive oxygen species such as catalase, peroxirredoxine-1, and glutathione-S-transferase P1 and Mu1 were highly expressed as evidenced by proteome analysis; hepatic catalase activity was increased in SPARC-/- mice. Reactive Oxygen Species 39-62 catalase Mus musculus 71-79 31289615-8 2019 Proteins involved in detoxification of reactive oxygen species such as catalase, peroxirredoxine-1, and glutathione-S-transferase P1 and Mu1 were highly expressed as evidenced by proteome analysis; hepatic catalase activity was increased in SPARC-/- mice. Reactive Oxygen Species 39-62 catalase Mus musculus 206-214 25529987-4 2015 A transgenic mouse model overexpressing catalase within mitochondria was applied to show the contribution of mitochondrial reactive oxygen species to ischaemia-reperfusion injuries in different brain regions. Reactive Oxygen Species 123-146 catalase Mus musculus 40-48 26456065-2 2015 Overexpression of catalase via a heart-specific promoter (CAT-TG) was reported to reduce diabetes-induced accumulation of reactive oxygen species (ROS) and further prevent diabetes-induced pathological abnormalities, including cardiac structural derangement and left ventricular abnormity in mice. Reactive Oxygen Species 122-145 catalase Mus musculus 18-26 26456065-2 2015 Overexpression of catalase via a heart-specific promoter (CAT-TG) was reported to reduce diabetes-induced accumulation of reactive oxygen species (ROS) and further prevent diabetes-induced pathological abnormalities, including cardiac structural derangement and left ventricular abnormity in mice. Reactive Oxygen Species 147-150 catalase Mus musculus 18-26 23507145-4 2014 Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity. Reactive Oxygen Species 35-58 catalase Mus musculus 120-128 24993069-7 2015 High fat diet intake promoted reactive oxygen species production and suppressed autophagy in the heart, the effects of which were attenuated by catalase. Reactive Oxygen Species 30-53 catalase Mus musculus 144-152 24949841-10 2015 CONCLUSION: Our article documents the neuroprotective properties of reducing mitochondrial reactive oxygen species through the targeted overexpression of catalase and how this ameliorates the adverse effects of proton irradiation in the brain. Reactive Oxygen Species 91-114 catalase Mus musculus 154-162 23507145-4 2014 Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity. Reactive Oxygen Species 60-63 catalase Mus musculus 120-128 25288788-9 2014 High glucose-inactivated FoxO1 decreases the expression of catalase to increase the production of ROS. Reactive Oxygen Species 98-101 catalase Mus musculus 59-67 25288788-12 2014 Together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of Akt involving inactivated FoxO1 and a decrease in catalase expression, leading to increased ROS and mesangial cell hypertrophy and matrix protein expression. Reactive Oxygen Species 218-221 catalase Mus musculus 176-184 24874428-6 2014 As expected, cardiomyocyte-directed expression of mitochondrial-targeted catalase at modest levels normalized mitochondrial ROS production and prevented mitochondrial depolarization, respiratory impairment, and structural degeneration in Mfn2 null hearts. Reactive Oxygen Species 124-127 catalase Mus musculus 73-81 25272153-9 2014 Wild-type hearts responded to ROS challenge with a profound decline in contractile function that was ameliorated by co-administration of catalase or dexrazoxane as positive controls. Reactive Oxygen Species 30-33 catalase Mus musculus 137-145 24874428-7 2014 In contrast, catalase expression at higher levels that supersuppressed mitochondrial ROS failed to improve either mitochondrial fitness or cardiomyopathy, revealing that ROS toxicity is not the primary mechanism for cardiac degeneration. Reactive Oxygen Species 85-88 catalase Mus musculus 13-21 24874428-11 2014 A therapeutic window for mitochondrial ROS suppression should minimize the former while retaining the latter, which we achieved by expressing lower levels of catalase. Reactive Oxygen Species 39-42 catalase Mus musculus 158-166 24480247-16 2014 Moreover, hGSTM2-MSCs increased expression of renal superoxide dismutase and catalase, which may associate with detoxifying reactive oxygen species to prevent oxidative renal damage. Reactive Oxygen Species 124-147 catalase Mus musculus 77-85 24093153-7 2014 Moreover, we found that, relative to wild-type platelets, platelets derived from glutathione peroxidase 1 (GPx1)/catalase double-deficient mice showed enhanced cellular ROS levels, oxidative inactivation of SHP-2, and tyrosine phosphorylation of Syk, Vav1, Btk, and PLCgamma2 in response to collagen, which subsequently led to increased intracellular calcium levels, degranulation, and integrin alphaIIbbeta3 activation. Reactive Oxygen Species 169-172 catalase Mus musculus 113-121 23839981-5 2013 In addition, the expression of ROS detoxifying enzymes (catalase and superoxide-dismutase 2) and the transactivation of peroxisome proliferators-activated receptor (PPAR)-alpha/-beta/-gamma including PPAR-gamma coactivator-1alpha were enhanced by LOV in similarly treated OLs. Reactive Oxygen Species 31-34 catalase Mus musculus 56-64 24025477-8 2013 In catalase knock-out mice, a decreased hydrogen peroxide removing capacity and increased reactive oxygen species formation were reported. Reactive Oxygen Species 90-113 catalase Mus musculus 3-11 23297316-5 2013 Abolishing the bystander effect of post-irradiation thymocytes by superoxide dismutase and catalase supports ROS involvement. Reactive Oxygen Species 109-112 catalase Mus musculus 91-99 23697797-3 2013 Data confirmed the changes in key regulatory processes for ROS (increased glutathione peroxidase 1 and catalase activities and reduced total glutathione content) previously reported in muscle from old mice and showed increased CM-DCFH oxidation in muscle fibers from old mice at rest and indicate that these changes are likely due to an increase in generation of oxidants rather than a lack of scavenging capacity. Reactive Oxygen Species 59-62 catalase Mus musculus 103-111 23360182-1 2013 Cellular defence against the formation of reactive oxygen species (ROS) involves a number of mechanisms in which antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) play an important role. Reactive Oxygen Species 42-65 catalase Mus musculus 141-149 23360182-1 2013 Cellular defence against the formation of reactive oxygen species (ROS) involves a number of mechanisms in which antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) play an important role. Reactive Oxygen Species 42-65 catalase Mus musculus 151-154 23360182-1 2013 Cellular defence against the formation of reactive oxygen species (ROS) involves a number of mechanisms in which antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) play an important role. Reactive Oxygen Species 67-70 catalase Mus musculus 141-149 23360182-1 2013 Cellular defence against the formation of reactive oxygen species (ROS) involves a number of mechanisms in which antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) play an important role. Reactive Oxygen Species 67-70 catalase Mus musculus 151-154 23011031-5 2013 Since oxidative stress and mitochondrial dysfunction are implicated in A-T, we determined whether reducing mitochondrial reactive oxygen species (ROS) via overexpression of catalase targeted to mitochondria (mCAT) alleviates A-T-related pathology in ATM(-/-) mice. Reactive Oxygen Species 121-144 catalase Mus musculus 173-181 23109558-2 2013 The scavenging of reactive oxygen species through their matrix enzyme catalase is one of the most recognized functions of peroxisomes. Reactive Oxygen Species 18-41 catalase Mus musculus 70-78 23011031-5 2013 Since oxidative stress and mitochondrial dysfunction are implicated in A-T, we determined whether reducing mitochondrial reactive oxygen species (ROS) via overexpression of catalase targeted to mitochondria (mCAT) alleviates A-T-related pathology in ATM(-/-) mice. Reactive Oxygen Species 121-144 catalase Mus musculus 208-212 23011031-5 2013 Since oxidative stress and mitochondrial dysfunction are implicated in A-T, we determined whether reducing mitochondrial reactive oxygen species (ROS) via overexpression of catalase targeted to mitochondria (mCAT) alleviates A-T-related pathology in ATM(-/-) mice. Reactive Oxygen Species 146-149 catalase Mus musculus 173-181 23011031-5 2013 Since oxidative stress and mitochondrial dysfunction are implicated in A-T, we determined whether reducing mitochondrial reactive oxygen species (ROS) via overexpression of catalase targeted to mitochondria (mCAT) alleviates A-T-related pathology in ATM(-/-) mice. Reactive Oxygen Species 146-149 catalase Mus musculus 208-212 23011031-7 2013 Our results suggest that positive effects observed on cancer development may be linked to mCAT reducing mitochondrial ROS, lactate production, and TORC1 signaling in transforming double-positive cells, whereas beneficial effects in memory T cells appear to be TORC1-independent. Reactive Oxygen Species 118-121 catalase Mus musculus 90-94 22374698-8 2012 Administration of an antioxidant chemical, N-acetylcysteine, or ectopically overexpressing a reactive oxygen species scavenging enzyme, catalase, improved the function of transplanted HSCs in irradiated hosts. Reactive Oxygen Species 93-116 catalase Mus musculus 136-144 22534037-11 2012 The expression of catalase was considerably up-regulated in HEMA-exposed cultures, implying that H(2)O(2) is the type of ROS that is significantly increased in monomer-exposed cells. Reactive Oxygen Species 121-124 catalase Mus musculus 18-26 22552367-10 2012 Inhibition of ROS generation by addition of SOD or catalase inhibited beta-catenin expression and activity. Reactive Oxygen Species 14-17 catalase Mus musculus 51-59 22253064-8 2012 The adipokines-induced increase in viability is ROS dependent as this effect was abolished by N-acetyl-L-cysteine (NAC) or PEG-catalase. Reactive Oxygen Species 48-51 catalase Mus musculus 127-135 22012956-8 2012 CONCLUSION: This is the first study to demonstrate that scavenging mitochondrial reactive oxygen species (ROS) by mCAT not only attenuates most of the mitochondrial proteome changes in heart failure, but also induces a subset of unique alterations. Reactive Oxygen Species 81-104 catalase Mus musculus 114-118 22012956-8 2012 CONCLUSION: This is the first study to demonstrate that scavenging mitochondrial reactive oxygen species (ROS) by mCAT not only attenuates most of the mitochondrial proteome changes in heart failure, but also induces a subset of unique alterations. Reactive Oxygen Species 106-109 catalase Mus musculus 114-118 21749277-6 2011 The promotion of migration/invasion, activation of PI3Ks and MAPKs and up-regulation of MMPs were inhibited by the general reactive oxygen species scavenger N-acetyl-l-cysteine (NAC), over-expression of the H(2)O(2)-detoxifying enzyme mitochondrial catalase (mCat) and specific inhibitors of AKTs or ERKs. Reactive Oxygen Species 123-146 catalase Mus musculus 259-263 21963838-9 2011 In contrast, upregulation of CuZnSOD and catalase in resistance arteries is sufficient to protect vascular tissue from increased production of reactive oxygen species generated by uncoupling of eNOS. Reactive Oxygen Species 143-166 catalase Mus musculus 41-49 21478259-1 2011 Oxidative stress and reactive oxygen species (ROS) such as hydrogen peroxide (H(2)O(2)), which is detoxified by catalase, are implicated in fetal death and birth defects. Reactive Oxygen Species 21-44 catalase Mus musculus 112-120 21478259-1 2011 Oxidative stress and reactive oxygen species (ROS) such as hydrogen peroxide (H(2)O(2)), which is detoxified by catalase, are implicated in fetal death and birth defects. Reactive Oxygen Species 46-49 catalase Mus musculus 112-120 21295602-2 2011 Embryonic catalase, although expressed at about 5% of maternal activity, may protect the embryo by detoxifying ROS. Reactive Oxygen Species 111-114 catalase Mus musculus 10-18 21605372-9 2011 PyMT tumor cells expressing mCAT had lower ROS levels and were more resistant to hydrogen peroxide-induced oxidative stress than wild type tumor cells, suggesting that mCAT has the potential of quenching intracellular ROS and subsequent invasive behavior. Reactive Oxygen Species 43-46 catalase Mus musculus 28-32 21605372-9 2011 PyMT tumor cells expressing mCAT had lower ROS levels and were more resistant to hydrogen peroxide-induced oxidative stress than wild type tumor cells, suggesting that mCAT has the potential of quenching intracellular ROS and subsequent invasive behavior. Reactive Oxygen Species 43-46 catalase Mus musculus 168-172 21605372-9 2011 PyMT tumor cells expressing mCAT had lower ROS levels and were more resistant to hydrogen peroxide-induced oxidative stress than wild type tumor cells, suggesting that mCAT has the potential of quenching intracellular ROS and subsequent invasive behavior. Reactive Oxygen Species 218-221 catalase Mus musculus 28-32 21605372-9 2011 PyMT tumor cells expressing mCAT had lower ROS levels and were more resistant to hydrogen peroxide-induced oxidative stress than wild type tumor cells, suggesting that mCAT has the potential of quenching intracellular ROS and subsequent invasive behavior. Reactive Oxygen Species 218-221 catalase Mus musculus 168-172 21605372-11 2011 Expression of mCAT in the lungs increased resistance to hydrogen peroxide-induced oxidative stress that was associated with decreased activation of p38MAPK suggesting ROS signaling is dependent on p38MAPK for at least some of its downstream effects. Reactive Oxygen Species 167-170 catalase Mus musculus 14-18 21605372-12 2011 CONCLUSION: Targeting catalase within mitochondria of tumor cells and tumor stromal cells suppresses ROS-driven tumor progression and metastasis. Reactive Oxygen Species 101-104 catalase Mus musculus 22-30 21311045-4 2011 The causal role of mitochondrial ROS in angiotensin II-induced cardiomyopathy is shown by the observation that mice that overexpress catalase targeted to mitochondria, but not mice that overexpress wild-type peroxisomal catalase, are resistant to cardiac hypertrophy, fibrosis and mitochondrial damage induced by angiotensin II, as well as heart failure induced by overexpression of Galphaq. Reactive Oxygen Species 33-36 catalase Mus musculus 133-141 21044652-2 2011 Superoxide dismutase (SOD) and catalase conjugated with antibodies to Platelet-Endothelial Cell Adhesion Molecule-1 (anti-PECAM/SOD and anti-PECAM/catalase) bind to endothelium, accumulate in the pulmonary vasculature, and detoxify reactive oxygen species. Reactive Oxygen Species 232-255 catalase Mus musculus 31-39 21044652-2 2011 Superoxide dismutase (SOD) and catalase conjugated with antibodies to Platelet-Endothelial Cell Adhesion Molecule-1 (anti-PECAM/SOD and anti-PECAM/catalase) bind to endothelium, accumulate in the pulmonary vasculature, and detoxify reactive oxygen species. Reactive Oxygen Species 232-255 catalase Mus musculus 147-155 20876216-2 2011 Catalase and superoxide dismutase (SOD) conjugated with antibodies to platelet/endothelial cell adhesion molecule 1 (PECAM-1) bind specifically to endothelium and inhibit effects of corresponding ROS, H(2)O(2), and superoxide anion. Reactive Oxygen Species 196-199 catalase Mus musculus 0-8 19956688-8 2009 Consistently, the FoxO targets, Sod2 and catalase, were significantly down-regulated in Mst1(-/-) T cells, thereby resulting in elevated levels of intracellular reactive oxygen species (ROS) and induction of apoptosis. Reactive Oxygen Species 161-184 catalase Mus musculus 41-49 20883752-6 2010 The signaling pathway induced by simvastatin breaks down the antioxidant defense system by suppressing the expression of reactive oxygen species scavengers, particularly Mn-SOD, CAT, GPx1, and SESN 3, thereby inducing oxidative stress and apoptotic cell death. Reactive Oxygen Species 121-144 catalase Mus musculus 178-181 20496172-7 2010 Experiments with (cell-permeable) superoxide dismutase or catalase, N-acetylcysteine and apocynin suggest that the ROS-dependent shock depends on intracellular (*)OH radicals. Reactive Oxygen Species 115-118 catalase Mus musculus 58-66 20171267-7 2010 Moreover, exposure of MPMVEC to Nano-CuO caused reactive oxygen species (ROS) generation that was abolished by pre-treatment of cells with ROS scavengers or inhibitors, DPI, NAC and catalase. Reactive Oxygen Species 48-71 catalase Mus musculus 182-190 20171267-7 2010 Moreover, exposure of MPMVEC to Nano-CuO caused reactive oxygen species (ROS) generation that was abolished by pre-treatment of cells with ROS scavengers or inhibitors, DPI, NAC and catalase. Reactive Oxygen Species 73-76 catalase Mus musculus 182-190 20171267-7 2010 Moreover, exposure of MPMVEC to Nano-CuO caused reactive oxygen species (ROS) generation that was abolished by pre-treatment of cells with ROS scavengers or inhibitors, DPI, NAC and catalase. Reactive Oxygen Species 139-142 catalase Mus musculus 182-190 19956688-8 2009 Consistently, the FoxO targets, Sod2 and catalase, were significantly down-regulated in Mst1(-/-) T cells, thereby resulting in elevated levels of intracellular reactive oxygen species (ROS) and induction of apoptosis. Reactive Oxygen Species 186-189 catalase Mus musculus 41-49 19684199-0 2009 Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Reactive Oxygen Species 14-37 catalase Mus musculus 49-57 19684199-7 2009 To determine whether ROS generation contributed to pulmonary fibrosis, we overexpressed catalase in WT monocytes and observed a decrease in ROS generation in vitro. Reactive Oxygen Species 140-143 catalase Mus musculus 88-96 19839801-1 2009 Superoxide dismutase (SOD) and catalase (CAT) are active scavengers of reactive oxygen species and were incorporated into ultradeformable vesicles with the aim of increasing enzyme bioavailability (skin delivery). Reactive Oxygen Species 71-94 catalase Mus musculus 41-44 18203709-7 2008 The TRPV1-mediated vasodilatation was also attenuated by treatment with superoxide dismutase and the hydrogen peroxide scavenger catalase, but not by deactivated enzymes, supporting a novel role for reactive oxygen species (ROS) generation. Reactive Oxygen Species 199-222 catalase Mus musculus 129-137 19531609-11 2009 These data suggest that glucose-deprived cleavage stage embryos, although supplied with sufficient monocarboxylate-derived energy, undergo oxidative stress and exhibit elevated ROS, which in turn upregulates PPARA, catalase and SLC16A7 in a classical peroxisomal proliferation response. Reactive Oxygen Species 177-180 catalase Mus musculus 215-223 19361547-1 2009 Catalase delivery can be effective in inhibiting reactive oxygen species (ROS)-mediated acceleration of tumor metastasis. Reactive Oxygen Species 49-72 catalase Mus musculus 0-8 19361547-1 2009 Catalase delivery can be effective in inhibiting reactive oxygen species (ROS)-mediated acceleration of tumor metastasis. Reactive Oxygen Species 74-77 catalase Mus musculus 0-8 19666105-1 2009 A reduction in endogenously generated reactive oxygen species in vivo delays benzo(a)pyrene (BaP)-accelerated atherosclerosis, as revealed in hypercholesterolemic mice overexpressing Cu/Zn-superoxide dismutase (SOD) and/or catalase. Reactive Oxygen Species 38-61 catalase Mus musculus 223-231 18722522-1 2008 Catalase plays an important role in protecting organisms against oxidative damage caused by reactive oxygen species (ROS) by degrading surplus hydrogen peroxide. Reactive Oxygen Species 92-115 catalase Mus musculus 0-8 18722522-1 2008 Catalase plays an important role in protecting organisms against oxidative damage caused by reactive oxygen species (ROS) by degrading surplus hydrogen peroxide. Reactive Oxygen Species 117-120 catalase Mus musculus 0-8 18722522-2 2008 Addition of exogenous catalase can alleviate injuries caused by ROS. Reactive Oxygen Species 64-67 catalase Mus musculus 22-30 18203709-9 2008 Finally, a role of neuropeptides in initiating a ROS-dependent component was verified as superoxide dismutase, catalase, and apocynin inhibited SP and CGRP vasodilatation. Reactive Oxygen Species 49-52 catalase Mus musculus 111-119 17342175-7 2007 Our results show that the overexpression of catalase prevents the stimulation of ROS and angiotensinogen mRNA in tubules owing to elevated glucose or angiotensin II in vitro. Reactive Oxygen Species 81-84 catalase Mus musculus 44-52 18089839-5 2008 It was also found that STZ treatment induced higher levels of reactive oxygen species, which was abolished with concomitant treatment with catalase. Reactive Oxygen Species 62-85 catalase Mus musculus 139-147 18171680-9 2008 The decrease in catalase expression led to an elevated level of reactive oxygen species. Reactive Oxygen Species 64-87 catalase Mus musculus 16-24 17786570-1 2008 The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. Reactive Oxygen Species 142-165 catalase Mus musculus 72-80 17342175-8 2007 Additionally, overexpression of catalase attenuated ROS generation, angiotensinogen and proapoptotic gene expression and apoptosis in the kidneys of diabetic mice in vivo. Reactive Oxygen Species 52-55 catalase Mus musculus 32-40 16586065-11 2006 Catalase ablated insulin-resistance-induced mechanical dysfunction, ROS production and protein damage, and reduced eNOS, but not insulin insensitivity. Reactive Oxygen Species 68-71 catalase Mus musculus 0-8 16910779-4 2006 For glutathione peroxidase and catalase to detoxify reactive oxygen species (ROS), reducing equivalents in the form of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) are ultimately required. Reactive Oxygen Species 52-75 catalase Mus musculus 31-39 16910779-4 2006 For glutathione peroxidase and catalase to detoxify reactive oxygen species (ROS), reducing equivalents in the form of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) are ultimately required. Reactive Oxygen Species 77-80 catalase Mus musculus 31-39 16970930-1 2006 We tested the effects of salen manganese (Salen-Mn) complexes, which are scavengers of reactive oxygen species exhibiting superoxide dismutase and catalase activities on the rejection of and alloresponse to fully allogeneic skin grafts in mice. Reactive Oxygen Species 87-110 catalase Mus musculus 147-155 16586065-13 2006 CONCLUSIONS/INTERPRETATION: These data indicate that catalase rescues insulin-resistance-induced cardiac dysfunction related to ROS production and protein oxidation but probably does not improve insulin sensitivity. Reactive Oxygen Species 128-131 catalase Mus musculus 53-61 15816327-11 2005 Reactive oxygen species production is also involved in this process since superoxide dismutase/catalase-mimetics or catalase overexpression prevent beta-AR-stimulated apoptosis. Reactive Oxygen Species 0-23 catalase Mus musculus 95-124 16629652-5 2006 METHODS/RESULTS: We observed increased oxidative damage and higher levels of reactive oxygen species, measured by thiobarbituric acid reactive species and 2",7"-dichlorofluorescein diacetate, respectively, and diminished catalase activity in activated cells. Reactive Oxygen Species 77-100 catalase Mus musculus 221-229 16900947-6 2006 The results obtained show the binomial SOD/CAT as an important factor for counteracting reactive oxygen species-dependent damage. Reactive Oxygen Species 88-111 catalase Mus musculus 43-46 17166877-4 2006 Our results show that these SOD/catalase mimetics apparently increase the oxidation of a ROS-sensitive fluorescent indicator dye, particularly after short (12 h) treatments, but that longer treatments (24 h) decrease oxidation attributable to radiation-induced ROS. Reactive Oxygen Species 89-92 catalase Mus musculus 32-40 17166877-4 2006 Our results show that these SOD/catalase mimetics apparently increase the oxidation of a ROS-sensitive fluorescent indicator dye, particularly after short (12 h) treatments, but that longer treatments (24 h) decrease oxidation attributable to radiation-induced ROS. Reactive Oxygen Species 261-264 catalase Mus musculus 32-40 17166877-10 2006 Our results also show that the ability of catalase mimetics, like true catalases, to catalyse peroxidase reactions can complicate the interpretation of data obtained with certain fluorescent ROS-indicator dyes. Reactive Oxygen Species 191-194 catalase Mus musculus 42-50 16216962-5 2005 Quantification of reactive oxygen species by fluorescence signals in cat++ versus catalase-negative (catn) mice showed a strong decrease in aortic endothelium and left ventricular myocardium but not in leukocytes. Reactive Oxygen Species 18-41 catalase Mus musculus 82-90 16107509-9 2006 Catalase, diphenyleneiodonium, and cromakalim markedly inhibited ROS production and cell proliferation in flow-adapted wild-type mPMVECs. Reactive Oxygen Species 65-68 catalase Mus musculus 0-8 14729509-9 2004 In addition, STAT activation required reactive oxygen species, as the overexpression of catalase in mice prevented LPS-mediated STAT activation in the lung. Reactive Oxygen Species 38-61 catalase Mus musculus 88-96 15288807-4 2004 The inhibition observed by these compounds was sensitive to superoxide dismutase and catalase, suggesting that reactive oxygen species may be mediators of their inhibition. Reactive Oxygen Species 111-134 catalase Mus musculus 85-93 10767579-3 2000 To explore this possibility, catalase (CAT), an enzyme involved in elimination of ROS, was evaluated in long-lived dwarf and short-lived transgenic mice. Reactive Oxygen Species 82-85 catalase Mus musculus 29-37 14651610-1 2004 Superoxide dismutase, catalase, glutathione peroxidase and peroxiredoxins form an antioxidant network protecting cells against reactive oxygen species (ROS). Reactive Oxygen Species 127-150 catalase Mus musculus 22-30 14651610-1 2004 Superoxide dismutase, catalase, glutathione peroxidase and peroxiredoxins form an antioxidant network protecting cells against reactive oxygen species (ROS). Reactive Oxygen Species 152-155 catalase Mus musculus 22-30 14756815-3 2004 Pre-treatment with superoxide dismutase (SOD)/catalase, or SOD/catalase mimetics that can scavenge intracellular ROS, significantly attenuated LPS-induced release in PGE2. Reactive Oxygen Species 113-116 catalase Mus musculus 46-54 14756815-3 2004 Pre-treatment with superoxide dismutase (SOD)/catalase, or SOD/catalase mimetics that can scavenge intracellular ROS, significantly attenuated LPS-induced release in PGE2. Reactive Oxygen Species 113-116 catalase Mus musculus 63-71 12377949-5 2002 Preincubation with catalase, cyclosporin A (CsA), and bongkrekic acid attenuated ROS production. Reactive Oxygen Species 81-84 catalase Mus musculus 19-27 11970911-4 2002 In myotubes, superoxide dismutase and catalase blocked the ROS-induced IL-6 release. Reactive Oxygen Species 59-62 catalase Mus musculus 38-46 11221962-8 2001 L1210 cells showed lower mitochondrial activities of enzymes involved in scavenging of reactive oxygen species, such as superoxide dismutase, glutathione peroxidase and catalase, than the other cells. Reactive Oxygen Species 87-110 catalase Mus musculus 169-177 10767579-3 2000 To explore this possibility, catalase (CAT), an enzyme involved in elimination of ROS, was evaluated in long-lived dwarf and short-lived transgenic mice. Reactive Oxygen Species 82-85 catalase Mus musculus 39-42 10693974-10 1999 The enzymes catalase and superoxide dismutase and the antioxidant agent selenium showed some protection against hydrazine neurotoxicity, suggesting an involvement of the generation of reactive oxygen species in the pathogenesis of isoniazid neuropathy. Reactive Oxygen Species 184-207 catalase Mus musculus 12-20 7623765-0 1995 Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity. Reactive Oxygen Species 159-182 catalase Mus musculus 136-144 10230805-8 1999 These results suggest that catalase can be used for various hepatic injuries caused by ROS. Reactive Oxygen Species 87-90 catalase Mus musculus 27-35 9895216-11 1999 Both the SOD-mediated enhancement of phenytoin teratogenicity, and the inhibition of phenytoin teratogenicity by catalase, indicate a critical role for ROS in the teratologic mechanism, and the teratologic importance of antioxidative balance. Reactive Oxygen Species 152-155 catalase Mus musculus 113-121 9168957-5 1997 Proliferation was also inhibited by superoxide dismutase, catalase, and mannitol, implicating reactive oxygen species, although superoxide dismutase and catalase also inhibited alkyl radical formation, as determined by spin-trapping. Reactive Oxygen Species 94-117 catalase Mus musculus 58-66 8521386-7 1995 administration of superoxide dismutase or catalase, at the time when vascular reperfusion occurred, resulted in a significant protection against tumor cell kill, suggesting that the damage was mediated by oxygen radicals. Reactive Oxygen Species 205-220 catalase Mus musculus 42-50 9274453-3 1997 Studies on lymphocytes, stimulated in vitro by ROS to induce angiogenesis, showed that only the enzyme catalase (CAT) could block the activation. Reactive Oxygen Species 47-50 catalase Mus musculus 103-111 9274453-7 1997 Moreover, when the ROS scavenger enzyme activities (superoxide dismutase (SDM) and CAT) were determined, we observed low CAT activity in normal spleens, reflected in a high SDM/CAT ratio, when compared to liver or kidney values. Reactive Oxygen Species 19-22 catalase Mus musculus 121-124 9274453-7 1997 Moreover, when the ROS scavenger enzyme activities (superoxide dismutase (SDM) and CAT) were determined, we observed low CAT activity in normal spleens, reflected in a high SDM/CAT ratio, when compared to liver or kidney values. Reactive Oxygen Species 19-22 catalase Mus musculus 121-124 8902218-5 1996 Two ROS scavengers, superoxide dismutase and catalase, attenuated the inhibition of sperm-egg fusion by HX-XO. Reactive Oxygen Species 4-7 catalase Mus musculus 45-53 8784817-3 1996 The methylmercury neurotoxicity was blocked by oxygen radical scavengers such as glutathione, catalase, selenium, and cysteine. Reactive Oxygen Species 47-61 catalase Mus musculus 94-102 7623765-1 1995 A murine embryo culture model was used to investigate phenytoin-initiated embryonic DNA oxidation and dysmorphogenesis and to determine the embryoprotective potential of superoxide dismutase and catalase, which detoxify reactive oxygen species. Reactive Oxygen Species 220-243 catalase Mus musculus 195-203 2215531-6 1990 Here, we studied the expression and developmental profile of the three enzymes of oxygen radical metabolism (superoxide dismutase, glutathione peroxidase, and catalase) during development. Reactive Oxygen Species 82-96 catalase Mus musculus 159-167 7883952-2 1995 These defense mechanisms include enzymes such as catalase, which detoxify reactive oxygen species, and DNA repair systems which repair damage resulting from oxidative stress. Reactive Oxygen Species 74-97 catalase Mus musculus 49-57 1554388-1 1992 Pretreatment with the reactive oxygen species scavengers superoxide dismutase (SOD) and catalase or with the xanthine oxidase inhibitor allopurinol protected mice against hepatitis induced by the combined administration of lipopolysaccharide (endotoxin) and D-galactosamine. Reactive Oxygen Species 22-45 catalase Mus musculus 88-96 34888304-4 2021 We report herein a treatment for sepsis based on PEGylated catalase, which can effectively break down hydrogen peroxide, a key component of ROS that is chemically stable and able to diffuse around the tissues and form downstream ROS. Reactive Oxygen Species 140-143 catalase Mus musculus 59-67 32796955-8 2021 We found that baicalein pretreatment increased the expression of catalase and the mitophagy receptor FUN14 domain containing 1 (FUNDC1) to clear ROS and promote autophagy, thus attenuated ISO-induced cardiac hypertrophy. Reactive Oxygen Species 145-148 catalase Mus musculus 65-73 2090377-4 1990 Catalase effects the breakdown of H2O2 to O2 and H2O and offers protection against the toxic effects of oxygen radicals. Reactive Oxygen Species 104-119 catalase Mus musculus 0-8 34876210-0 2021 Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting. Reactive Oxygen Species 119-122 catalase Mus musculus 0-8 34888304-4 2021 We report herein a treatment for sepsis based on PEGylated catalase, which can effectively break down hydrogen peroxide, a key component of ROS that is chemically stable and able to diffuse around the tissues and form downstream ROS. Reactive Oxygen Species 229-232 catalase Mus musculus 59-67 34598016-4 2021 Fortunately, several mechanisms exist to buffer bursts of intracellular ROS and peroxide production, including the enzymes Catalase, Glutathione Peroxidase and Superoxide Dismutase (SOD). Reactive Oxygen Species 72-75 catalase Mus musculus 123-131 35477452-5 2022 RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Reactive Oxygen Species 66-69 catalase Mus musculus 122-130 34196954-1 2021 The antioxidant enzyme catalase represents an important therapeutic target due to its role in mitigating cellular reactive oxygen species that contribute to the pathogenesis of many disease states. Reactive Oxygen Species 114-137 catalase Mus musculus 23-31 35446788-0 2022 Photoinactivation of catalase sensitizes wide-ranging bacteria to ROS-producing agents and immune cells. Reactive Oxygen Species 66-69 catalase Mus musculus 21-29 34371438-9 2021 Our results demonstrated the detrimental effect of EMF via ROS accumulation that reduced the expression of catalase antioxidant, cell viability and colonization of SSCs. Reactive Oxygen Species 59-62 catalase Mus musculus 107-115 34181029-8 2021 Reactive oxygen species (ROS) were detected using CellROX Green and catalase activity by fluorometry. Reactive Oxygen Species 0-23 catalase Mus musculus 69-77 34181029-8 2021 Reactive oxygen species (ROS) were detected using CellROX Green and catalase activity by fluorometry. Reactive Oxygen Species 25-28 catalase Mus musculus 69-77 35477452-5 2022 RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Reactive Oxygen Species 204-207 catalase Mus musculus 122-130 35477452-5 2022 RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Reactive Oxygen Species 254-257 catalase Mus musculus 122-130 2550367-8 1989 The exogenous addition of compounds that antagonize or inhibit the formation of oxygen radicals (superoxide dismutase, catalase, dimethyl sulfoxide, or sodium azide) significantly inhibited fungal killing by both normal and IFN-activated PB-PMNs. Reactive Oxygen Species 80-95 catalase Mus musculus 119-127 34030116-5 2021 In addition, Hcy induced activation in podocytes of NLRP3 inflammasomes and the formation of multivesicular bodies (MVBs) containing inflammatory cytokines, which were prevented by treatment with gp91 ds-tat or the ROS scavenger, catalase. Reactive Oxygen Species 215-218 catalase Mus musculus 230-238 2669924-13 1989 The protective effect of superoxide dismutase and catalase lends support to the idea that reactive oxygen species are involved in the pathology of experimental cerebral malaria. Reactive Oxygen Species 90-113 catalase Mus musculus 50-58 32466897-4 2020 Further mechanistic studies demonstrated that MAH reduces ROS levels through increasing NF-E2-related factor 2-mediated expression of catalase, heme oxygenase-1, and genes involved in glutathione synthesis. Reactive Oxygen Species 58-61 catalase Mus musculus 134-142 33606716-3 2021 Here, we show that inhibition of catalase by 3-aminotriazole (3-AT) results in the generation of peroxisomal ROS, which contribute to leaky peroxisomes in RAW264.7 cells. Reactive Oxygen Species 109-112 catalase Mus musculus 33-41 33298178-8 2020 ROS level was evaluated by the ROS probe DCFH-DA, mitochondrial membrane potential (DeltaPsim) assay, SOD1/2, CAT, and GPx expression. Reactive Oxygen Species 0-3 catalase Mus musculus 110-113 32943886-9 2020 Moreover, the production of ROS was increased in cells treated with siTRPM8, which was accompanied by increased levels of Catalase, HO-1 and SOD2. Reactive Oxygen Species 28-31 catalase Mus musculus 122-130 33725585-5 2021 SOD and CAT co-loaded WCC nanoparticles (SC/WCC) can integrate the synergistic effect of SOD and CAT for enhancing the removal of reactive oxygen species (ROS), effectively inhibit the inflammatory response by reducing the secretion of proinflammatory factors and protect cells from ROS-induced oxidative damage. Reactive Oxygen Species 130-153 catalase Mus musculus 8-11 33725585-5 2021 SOD and CAT co-loaded WCC nanoparticles (SC/WCC) can integrate the synergistic effect of SOD and CAT for enhancing the removal of reactive oxygen species (ROS), effectively inhibit the inflammatory response by reducing the secretion of proinflammatory factors and protect cells from ROS-induced oxidative damage. Reactive Oxygen Species 130-153 catalase Mus musculus 97-100 33725585-5 2021 SOD and CAT co-loaded WCC nanoparticles (SC/WCC) can integrate the synergistic effect of SOD and CAT for enhancing the removal of reactive oxygen species (ROS), effectively inhibit the inflammatory response by reducing the secretion of proinflammatory factors and protect cells from ROS-induced oxidative damage. Reactive Oxygen Species 155-158 catalase Mus musculus 8-11 33725585-5 2021 SOD and CAT co-loaded WCC nanoparticles (SC/WCC) can integrate the synergistic effect of SOD and CAT for enhancing the removal of reactive oxygen species (ROS), effectively inhibit the inflammatory response by reducing the secretion of proinflammatory factors and protect cells from ROS-induced oxidative damage. Reactive Oxygen Species 155-158 catalase Mus musculus 97-100 33725585-5 2021 SOD and CAT co-loaded WCC nanoparticles (SC/WCC) can integrate the synergistic effect of SOD and CAT for enhancing the removal of reactive oxygen species (ROS), effectively inhibit the inflammatory response by reducing the secretion of proinflammatory factors and protect cells from ROS-induced oxidative damage. Reactive Oxygen Species 283-286 catalase Mus musculus 8-11 33496364-0 2021 Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting. Reactive Oxygen Species 28-51 catalase Mus musculus 0-8 33496364-2 2021 Although we showed that catalase depletion induces ROS-mediated pexophagy in cells, the effect of catalase deficiency during conditions that favor ROS generation remains elusive in mice. Reactive Oxygen Species 51-54 catalase Mus musculus 24-32 33496364-3 2021 In this study, we reported that prolonged fasting in catalase-knockout (KO) mice drastically increased ROS production, which induced liver-specific pexophagy, an autophagic degradation of peroxisomes. Reactive Oxygen Species 103-106 catalase Mus musculus 53-61 33496364-4 2021 In addition, increased ROS generation induced the production of pro-inflammatory cytokines in the liver tissues of catalase-KO mice. Reactive Oxygen Species 23-26 catalase Mus musculus 115-123 33496364-9 2021 Taken together, our data suggest that ROS-mediated liver-specific pexophagy observed during prolonged fasting in catalase-KO mice may be responsible for the process associated with hepatic cell death. Reactive Oxygen Species 38-41 catalase Mus musculus 113-121 32783660-9 2020 In sum, mitochondrial ROS signaling via H2O2 was important for the acquisition of adult bone structure and catalase overexpression failed to protect cancellous tissue from treatment. Reactive Oxygen Species 22-25 catalase Mus musculus 107-115 32783660-10 2020 In contrast, catabolic stimuli caused radial expansion in mCAT not WT mice, suggesting that mitochondrial ROS in skeletal cells act to suppress tissue turnover in response to remodeling challenges. Reactive Oxygen Species 106-109 catalase Mus musculus 58-62 31088291-8 2019 Overexpression of mCAT normalized ROS and ATP production in isolated mitochondria, and it corrected myocardial [PCr] and DeltaG~ATP in the beating heart. Reactive Oxygen Species 34-37 catalase Mus musculus 18-22 31088291-11 2019 These effects precede structural remodeling and are corrected by mCAT, indicating that ROS-mediated energetic impairment, per se, is sufficient to cause contractile dysfunction in MHD. Reactive Oxygen Species 87-90 catalase Mus musculus 65-69 32694785-7 2019 We generated mice that inducibly overexpress mitochondrial-tagged catalase in astrocytes and show that this overexpression decreases mitochondrial ROS production in these cells during adulthood. Reactive Oxygen Species 147-150 catalase Mus musculus 66-74 28826225-6 2018 This was followed by an increased proliferative phenotype via the AKT-dependent pathway that was perturbed in the presence of catalase-inhibitor, 3-aminotriazole due to an increased ROS-mediated inactivation of AKT. Reactive Oxygen Species 182-185 catalase Mus musculus 126-134 28826225-10 2018 Innovation and Conclusion: Our study suggests a distinct role of catalase that protects BMSCs and HSPCs from low ROS and promotes proliferation. Reactive Oxygen Species 113-116 catalase Mus musculus 65-73 28629836-6 2017 Moderate MnSOD and/or catalase overexpression in des-/- hearts leads to a marked decrease in intracellular reactive oxygen species (ROS), ameliorates mitochondrial and other ultrastructural defects, minimizes myocardial degeneration and leads to a significant improvement of cardiac function. Reactive Oxygen Species 107-130 catalase Mus musculus 22-30 28629836-6 2017 Moderate MnSOD and/or catalase overexpression in des-/- hearts leads to a marked decrease in intracellular reactive oxygen species (ROS), ameliorates mitochondrial and other ultrastructural defects, minimizes myocardial degeneration and leads to a significant improvement of cardiac function. Reactive Oxygen Species 132-135 catalase Mus musculus 22-30 29709906-6 2018 In addition, intracellular ROS production was effectively reduced by DBM treatment, which upregulated antioxidant genes such as glutathione peroxidase (Gpx), catalase (CAT), and superoxide dismutase 1 (SOD1). Reactive Oxygen Species 27-30 catalase Mus musculus 158-166 29709906-6 2018 In addition, intracellular ROS production was effectively reduced by DBM treatment, which upregulated antioxidant genes such as glutathione peroxidase (Gpx), catalase (CAT), and superoxide dismutase 1 (SOD1). Reactive Oxygen Species 27-30 catalase Mus musculus 168-171