PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17626151-5 2007 hCG treatment of IFN-gamma-primed Mvarphi resulted in increased production of NO, reactive oxygen species, IL-6 and IL-12p40, and enhanced phagocytosis of apoptotic cells. Reactive Oxygen Species 82-105 interferon gamma Homo sapiens 17-26 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 180-203 interferon gamma Homo sapiens 90-106 17477920-3 2007 The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. Reactive Oxygen Species 279-302 interferon gamma Homo sapiens 4-13 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 180-203 interferon gamma Homo sapiens 108-117 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 205-208 interferon gamma Homo sapiens 90-106 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 205-208 interferon gamma Homo sapiens 108-117 15716663-9 2005 RESULTS: Continuously stimulated colonic cells had increased ROS production, especially those stimulated with TNF-alpha or IFN-gamma/TNF-alpha (P<0.001). Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 123-132 16902148-5 2006 Moreover, the efficacy of IVIg-mediated neutrophil killing was enhanced by the proinflammatory cytokines granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-gamma), and this additional cell death required reactive oxygen species (ROSs) but not caspases. Reactive Oxygen Species 237-260 interferon gamma Homo sapiens 185-194 16902148-5 2006 Moreover, the efficacy of IVIg-mediated neutrophil killing was enhanced by the proinflammatory cytokines granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-gamma), and this additional cell death required reactive oxygen species (ROSs) but not caspases. Reactive Oxygen Species 262-266 interferon gamma Homo sapiens 185-194 16467537-5 2006 Furthermore, treatment with ACM suppressed interferon-gamma (IFN-gamma)-induced ROS production, leading to reduced inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) release. Reactive Oxygen Species 80-83 interferon gamma Homo sapiens 43-70 16842138-9 2006 In concert with other pro-inflammatory cytokines, interferon-gamma is the most important trigger for the formation and release of reactive oxygen species (ROS). Reactive Oxygen Species 130-153 interferon gamma Homo sapiens 50-66 16842138-9 2006 In concert with other pro-inflammatory cytokines, interferon-gamma is the most important trigger for the formation and release of reactive oxygen species (ROS). Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 50-66 16115026-7 2005 Moreover, phorbol 12-myristate 13-acetate-initiated ROS formation, which was attenuated in macrophages pretreated with IFNgamma, was restored in the presence of the PC-PLC inhibitor. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 119-127 12704788-0 2003 Interferon-gamma induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis. Reactive Oxygen Species 25-48 interferon gamma Homo sapiens 0-16 15352029-7 2004 Furthermore interferon-gamma suppressed the expression of selenoprotein P mRNA and increased intracellular ROS level, leading to the recovery of the gemcitabine sensitivity in KLM1-R. Reactive Oxygen Species 107-110 interferon gamma Homo sapiens 12-28 15318945-7 2004 The S100A4/IFN-gamma-mediated induction of apoptosis was shown to be independent of caspase activation, but dependent on the formation of reactive oxygen species. Reactive Oxygen Species 138-161 interferon gamma Homo sapiens 11-20 15265271-5 2004 Treatment of cultured brain endothelial cells with inflammatory proteins (LPS, IL-1beta, IL-6, IFN-gamma, TNF-alpha) resulted in a significant increase (p < 0.01) in intracellular levels of reactive oxygen species by 1 h. Inflammatory proteins also caused release of tissue plasminogen activator and increased apoptosis by 24 h in these cells. Reactive Oxygen Species 190-213 interferon gamma Homo sapiens 95-104 15037205-2 2004 IFN-gamma induced accumulation of ROS and activation of JNK and p38 in HSC536/N and PD149L but not in HSC99 cells. Reactive Oxygen Species 34-37 interferon gamma Homo sapiens 0-9 12948850-9 2003 Our results lead us to propose that IFNgamma initiates signal transduction, which alters the activities of CYP2E1 and iNOS, thereby producing reactive oxygen species. Reactive Oxygen Species 142-165 interferon gamma Homo sapiens 36-44 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. Reactive Oxygen Species 61-84 interferon gamma Homo sapiens 29-38 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. Reactive Oxygen Species 86-89 interferon gamma Homo sapiens 29-38 12704788-5 2003 However, IFN-gamma also induced the generation of ROS in IRF-1-deficient hepatocytes, cells insensitive to IFN-gamma-induced apoptosis. Reactive Oxygen Species 50-53 interferon gamma Homo sapiens 9-18 12704788-11 2003 Both the ROS and ER stress induced by IFN-gamma may be complementary mediators that induce apoptosis in primary hepatocytes. Reactive Oxygen Species 9-12 interferon gamma Homo sapiens 38-47 12628494-6 2003 Significantly lower doses of IFN-gamma induced ROS accumulation in neutrophils and mononuclear cell of FA patients compared to cells of normal individuals. Reactive Oxygen Species 47-50 interferon gamma Homo sapiens 29-38 12628494-7 2003 Enhanced ROS accumulation and decreased intracellular glutathione levels were observed in FA-C B-cell lines primed with IFN-gamma and treated with agonistic anti-Fas antibody than in isogenic control cells corrected with FANCC. Reactive Oxygen Species 9-12 interferon gamma Homo sapiens 120-129 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 48-57 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 69-78 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 69-78 12517959-6 2003 EGR-1 overexpression or treatment with monokine induced by IFN-gamma resulted in a ROS-dependent inhibition of basolateral Na(+)/K(+)-ATPase activity, compromising sodium transport in these cells. Reactive Oxygen Species 83-86 interferon gamma Homo sapiens 59-68 10685001-8 2000 Eighteen hour cytokine treatments with GM-CSF, IL-8, RANTES, IFN-gamma or TNF-alpha primed the cells for enhanced reactive oxygen species following exposure to an EOS stimulant. Reactive Oxygen Species 114-137 interferon gamma Homo sapiens 61-70 12006557-2 2002 We demonstrate that IFN-gamma induces the expression of HLA-DRA in vascular endothelial cells via mechanisms involving reactive oxygen species. Reactive Oxygen Species 119-142 interferon gamma Homo sapiens 20-29 12006557-8 2002 These results indicate that NO and antioxidants may attenuate vascular inflammation by antagonizing the effects of intracellular reactive oxygen species generation by IFN-gamma, which is necessary for MHC-II gene transcription. Reactive Oxygen Species 129-152 interferon gamma Homo sapiens 167-176 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. Reactive Oxygen Species 58-81 interferon gamma Homo sapiens 32-48 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. Reactive Oxygen Species 83-86 interferon gamma Homo sapiens 32-48 11742038-1 2001 The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells. Reactive Oxygen Species 221-235 interferon gamma Homo sapiens 105-132 11059641-7 2000 Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. Reactive Oxygen Species 47-70 interferon gamma Homo sapiens 6-15 11059641-7 2000 Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. Reactive Oxygen Species 72-75 interferon gamma Homo sapiens 6-15 10450792-8 1999 RESULTS: The base line and tumor necrosis factor (TNF)-alpha or interferon (IFN)-gamma induced ROS values were similar in the four groups, and the individual measures did not show a correlation with MS associated mtDNA haplotypes. Reactive Oxygen Species 95-98 interferon gamma Homo sapiens 64-86 11360598-13 1999 CONCLUSION: TNF-alpha and IFN-gamma could induce apoptosis of human trophoblasts during early pregnancy, partly through the mechanism of ROS. Reactive Oxygen Species 137-140 interferon gamma Homo sapiens 26-35 30439686-0 2019 Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-gamma in colon cancer. Reactive Oxygen Species 59-62 interferon gamma Homo sapiens 113-129 1649023-11 1991 Further support for this hypothesis was obtained after interferon-gamma treatment of human monocytes which led to an augmented PMA-inducible release of active oxygen radicals, but was not paralleled by growth restriction of L. monocytogenes. Reactive Oxygen Species 159-174 interferon gamma Homo sapiens 55-71 34893694-6 2021 CECs differentiated from peripheral blood mononuclear cells potently suppress T-cell activation, proliferation, and IFN-gamma production in an ARG- and ROS-dependent manner. Reactive Oxygen Species 152-155 interferon gamma Homo sapiens 116-125 34741776-4 2022 IFN-gamma induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Reactive Oxygen Species 107-130 interferon gamma Homo sapiens 0-9 34318944-6 2021 Furthermore, IFNgamma increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. Reactive Oxygen Species 32-55 interferon gamma Homo sapiens 13-21 2511088-5 1989 Stimulation of macrophages isolated from normal colon with interferon-gamma produced only a small increase in the proportion of cells showing release of oxygen radicals. Reactive Oxygen Species 153-168 interferon gamma Homo sapiens 59-75 33834624-7 2021 Functionally, IL-9/IL-9R signaling reduced the production of IFNgamma-induced toxic reactive oxygen species (ROS) in HPMs. Reactive Oxygen Species 109-112 interferon gamma Homo sapiens 61-69 33653884-13 2021 This study shows that one such secreted protein, ROP16, enables efficient parasite growth and survival by suppressing IFN-gamma-independent production of ROS by human and mouse cells. Reactive Oxygen Species 154-157 interferon gamma Homo sapiens 118-127 33577301-2 2021 It can not only generate reactive oxygen species (ROS) to cause the chemical damage of tumor cells in the presence of enough oxygen but also promote the antitumor immunity of T cells through enhancing the production of interferon gamma (IFN-gamma). Reactive Oxygen Species 25-48 interferon gamma Homo sapiens 219-246 30487174-7 2019 Neutrophils from CVID patients actively suppressed T cell activation and release of IFN-gamma via the production of reactive oxygen species. Reactive Oxygen Species 116-139 interferon gamma Homo sapiens 84-93 8890975-1 1996 The effects of cytokines (interleukin-2, tumor necrosis factor-alpha and interferon-gamma) on the ability of peripheral blood monocytes and alveolar macrophages to produce oxygen radicals were examined by the chemiluminescence assay in patients with lung cancer. Reactive Oxygen Species 172-187 interferon gamma Homo sapiens 73-89 8824667-4 1996 Leukocytospermia is associated with reduced in vitro fertilization rate, and experimentally-measured sperm functions (e.g., motility) are inhibited by high concentrations of certain WBC products (e.g., reactive oxygen species and interferon-gamma). Reactive Oxygen Species 202-225 interferon gamma Homo sapiens 230-246 8386028-2 1993 We have examined whether monocytes from children with chronic granulomatous disease (CGD) can be primed by cytokines other than interferon-gamma (IFN gamma), which has been demonstrated to improve the production of reactive oxygen species in vivo and in vitro. Reactive Oxygen Species 215-238 interferon gamma Homo sapiens 146-155 2163140-2 1990 Interferon-gamma (IFN-gamma), a potent immunoregulatory lymphokine, is likely involved in control of ROS metabolism. Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 0-16 2163140-2 1990 Interferon-gamma (IFN-gamma), a potent immunoregulatory lymphokine, is likely involved in control of ROS metabolism. Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 18-27 34746009-12 2021 The frequencies of interferon-gamma (IFN-gamma) producing CD8+ and CD4+ T cells were significantly increased after being treated by the combination of UTMD and PDL-1 blockade, while the reactive oxygen species (ROS) production and the fraction of the TGF-beta-producing CD11b+ cells were significantly decreased. Reactive Oxygen Species 211-214 interferon gamma Homo sapiens 19-35 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Reactive Oxygen Species 102-125 interferon gamma Homo sapiens 44-60 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Reactive Oxygen Species 102-125 interferon gamma Homo sapiens 62-71 2541203-2 1989 We examined the interaction between IFN-gamma, LPS, and glucocorticoids on release of oxygen radicals by human monocytes cultured in vitro. Reactive Oxygen Species 86-101 interferon gamma Homo sapiens 36-45 33196459-7 2020 In retinoic acid-differentiated ATXN3/Q75-GFP SH-SY5Y cells inflamed with IFN-gamma-primed HMC3 conditioned medium, treatment with the tested compounds mitigated the increased caspase 1 activity and lactate dehydrogenase release, reduced polyQ aggregation and ROS and/or promoted neurite outgrowth. Reactive Oxygen Species 260-263 interferon gamma Homo sapiens 74-83 26795536-6 2016 IFN-gamma induced ROS in mitochondria by inhibiting complex I and III, but not II. Reactive Oxygen Species 18-21 interferon gamma Homo sapiens 0-9 29551681-0 2018 Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. Reactive Oxygen Species 107-110 interferon gamma Homo sapiens 0-16 29551681-3 2018 We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. Reactive Oxygen Species 56-79 interferon gamma Homo sapiens 17-26 29551681-3 2018 We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. Reactive Oxygen Species 81-84 interferon gamma Homo sapiens 17-26 29551681-4 2018 The IFN-gamma-induced mitochondrial ROS generation was dependent on the activation of cytosolic phospholipase A2 (cPLA2). Reactive Oxygen Species 36-39 interferon gamma Homo sapiens 4-13 29551681-5 2018 In addition, a mitochondria-targeted antioxidant SS31 and/or cPLA2 inhibitor AACOCF3 abolished the IFN-gamma-induced ROS production and subsequent autophagy and apoptosis. Reactive Oxygen Species 117-120 interferon gamma Homo sapiens 99-108 29551681-8 2018 Collectively, our results suggested that IFN-gamma induces autophagy-associated apoptosis in CRC cells via inducing cPLA2-dependent mitochondrial ROS production. Reactive Oxygen Species 146-149 interferon gamma Homo sapiens 41-50 29182456-9 2017 Importantly, the levels of IFN-gamma and IL-10 consistently correlated with the generation of ROS, markers of damage and their free radical scavenging capacity. Reactive Oxygen Species 94-97 interferon gamma Homo sapiens 27-36 28396660-11 2017 As expected, Mphi-IFN-gamma showed significant production of ROS after FcgammaRI-, FcgammaRII-, or CD13-mediated phagocytosis. Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 18-27 27838900-0 2017 ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 13-29 27838900-4 2017 In this study, we examined IFN-gamma effect on the phosphorylation levels of key signaling proteins, through ROS production, in the human breast cancer cell line MCF-7. Reactive Oxygen Species 109-112 interferon gamma Homo sapiens 27-36 27838900-8 2017 On the other hand, IFN-gamma resulted in ROS generation, through H2O2 production, whereas pre-treatment with the ROS inhibitor NAC caused ROS inhibition and a significant decrease in the phosphorylation levels of AKT, ERK1/2, p38 and STAT1. Reactive Oxygen Species 41-44 interferon gamma Homo sapiens 19-28 27598576-0 2016 Mechanisms Underlying Interferon-gamma-Induced Priming of Microglial Reactive Oxygen Species Production. Reactive Oxygen Species 69-92 interferon gamma Homo sapiens 22-38 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 70-79 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 143-146 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 143-146 interferon gamma Homo sapiens 70-79 27575372-6 2016 By genetically silencing p47phox, IFN-gamma-induced ROS and mimic ETosis were significantly attenuated. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 34-43 27575372-8 2016 Furthermore, ROS promoted IFN-gamma-induced mimic ETosis in cooperation with autophagy. Reactive Oxygen Species 13-16 interferon gamma Homo sapiens 26-35 27575372-9 2016 These findings further demonstrate that ROS regulates IFN-gamma-induced mimic ETosis in lung epithelial malignancy. Reactive Oxygen Species 40-43 interferon gamma Homo sapiens 54-63 27486476-5 2016 Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (Deltapsim) and increased accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 119-142 interferon gamma Homo sapiens 15-23 27486476-5 2016 Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (Deltapsim) and increased accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 144-147 interferon gamma Homo sapiens 15-23 30272389-6 2019 IFN-gamma exposure also inhibited mitochondrial electron transport activity, and the accumulation of mitochondrial reactive oxygen species plays an important signaling role in this metabolic reconfiguration. Reactive Oxygen Species 115-138 interferon gamma Homo sapiens 0-9 27838900-11 2017 In summary, IFN-gamma signaling in MCF-7 cell line is ROS-dependent and follows the Src/Raf/ERK pathway whereas its signaling through the AKT pathway is highly dependent on NOX1. Reactive Oxygen Species 54-57 interferon gamma Homo sapiens 12-21 27598576-6 2016 Furthermore, IFNgamma-induced priming of microglial ROS production was reduced upon blockade of Kir2.1 inward rectifier K+ channels with ML133. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 13-21 26795536-7 2016 This ROS generation by IFN-gamma required de novo protein synthesis. Reactive Oxygen Species 5-8 interferon gamma Homo sapiens 23-32 27057461-3 2016 IFNgamma is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence. Reactive Oxygen Species 152-155 interferon gamma Homo sapiens 0-8 26549640-3 2015 Inhibition of NADPH oxidases or knockdown of gp91phox in CD8(+) T cells abrogates ROS generation, which in turn modulates JNK and NFkappaB signalling with decreases in both IFNgamma levels and CD39 expression. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 173-181 26288256-2 2015 We have reported that interferon-gamma (IFN-gamma) enhances FcgammaR-dependent ROS production. Reactive Oxygen Species 79-82 interferon gamma Homo sapiens 22-38 24725826-6 2014 The translocation and phosphorylation of p65, protein phosphatase 2A (PP2A) inactivation and the formation of reactive oxygen species (ROS) were significantly inhibited by PMC in LPS/IFN-gamma-activated VSMCs. Reactive Oxygen Species 110-133 interferon gamma Homo sapiens 183-192 27057461-3 2016 IFNgamma is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence. Reactive Oxygen Species 127-150 interferon gamma Homo sapiens 0-8 24725826-6 2014 The translocation and phosphorylation of p65, protein phosphatase 2A (PP2A) inactivation and the formation of reactive oxygen species (ROS) were significantly inhibited by PMC in LPS/IFN-gamma-activated VSMCs. Reactive Oxygen Species 135-138 interferon gamma Homo sapiens 183-192 24725826-11 2014 These results collectively indicate that the PMC-mediated inhibition of NF-kappaB activity in LPS/IFN-gamma-stimulated VSMCs occurs through the ROS-PP2A-p65 signalling cascade, an IKK-IkappaBalpha-independent mechanism. Reactive Oxygen Species 144-147 interferon gamma Homo sapiens 98-107 26021804-8 2015 IFN-gamma treatment dampened N-MDICs-mediated T cell activation through up-regulating T cell suppressive mediators, reactive oxygen species (ROS) and arginase I. Reactive Oxygen Species 116-139 interferon gamma Homo sapiens 0-9 26021804-8 2015 IFN-gamma treatment dampened N-MDICs-mediated T cell activation through up-regulating T cell suppressive mediators, reactive oxygen species (ROS) and arginase I. Reactive Oxygen Species 141-144 interferon gamma Homo sapiens 0-9 26513451-8 2015 However, the present studies also show that epithelial cells produce increased amounts of reactive oxygen species during stimulation with tumor necrosis factor-alpha and interferon-gamma resulting in DNA instability. Reactive Oxygen Species 90-113 interferon gamma Homo sapiens 170-186 25297574-11 2014 In conclusion, IFN-gamma sensitizes cells to MPP(+)-induced injury, also causing an increase in ROS levels. Reactive Oxygen Species 96-99 interferon gamma Homo sapiens 15-24 25317018-4 2014 CoCl2 reduced the generation of ROS induced by TNF-alpha/IFN-gamma. Reactive Oxygen Species 32-35 interferon gamma Homo sapiens 57-66 25317018-12 2014 We suggest that CoCl2 has a protective effect on TNF-alpha/IFN-gamma-induced inflammation through the inhibition of NF-kappaB and ROS in HK-2 cells. Reactive Oxygen Species 130-133 interferon gamma Homo sapiens 59-68 23999600-10 2014 gp120-expanded CD33(+) MDSCs inhibited IFN-gamma release from autologous T cells, which was restored upon ROS and iNOS inhibition. Reactive Oxygen Species 106-109 interferon gamma Homo sapiens 39-48 24368122-0 2014 In vitro activation of mouse neutrophils by recombinant human interferon-gamma: increased phagocytosis and release of reactive oxygen species and pro-inflammatory cytokines. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 62-78 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Reactive Oxygen Species 64-67 interferon gamma Homo sapiens 0-9 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Reactive Oxygen Species 90-93 interferon gamma Homo sapiens 150-159 23296709-2 2013 We recently demonstrated that dual oxidase (Duox)2, an NADPH oxidase essential for reactive oxygen species-related, gastrointestinal host defense, is regulated by IFN-gamma-mediated Stat1 binding to the Duox2 promoter in pancreatic tumor lines. Reactive Oxygen Species 83-106 interferon gamma Homo sapiens 163-172 23881028-12 2013 RT variants generating high total ROS levels induced significantly stronger IFN-gamma responses than the variants inducing lower total ROS, while high levels of ROS normalized per unit of protein in expressing cell were associated with a weak IFN-gamma response. Reactive Oxygen Species 34-37 interferon gamma Homo sapiens 76-85 23918204-6 2013 Although IFN-gamma alone had no effect, it potentiated IL-1beta-induced ROS production in a time-dependent manner. Reactive Oxygen Species 72-75 interferon gamma Homo sapiens 9-18 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 64-73 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. Reactive Oxygen Species 198-201 interferon gamma Homo sapiens 64-73 23526099-0 2013 Enhanced generation of reactive oxygen species by interferon-gamma may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease. Reactive Oxygen Species 23-46 interferon gamma Homo sapiens 50-66 23526099-4 2013 In this case, augmentation of ROS generation in the patient"s neutrophils was observed after in vivo IFN-gamma treatment, which may be attributable to the induction of a normal CYBB gene in the myeloid progenitor cells. Reactive Oxygen Species 30-33 interferon gamma Homo sapiens 101-110 23526099-6 2013 These results suggest that the in vivo use of IFN-gamma may augment ROS generation in CGD neutrophils, thus leading to the successful treatment of severe IPA. Reactive Oxygen Species 68-71 interferon gamma Homo sapiens 46-55 23085509-6 2014 Interferon-gamma triggers the high output of reactive oxygen species in macrophages, which can destroy the oxidation-labile BH4. Reactive Oxygen Species 45-68 interferon gamma Homo sapiens 0-16 23916683-6 2013 Addition of the ROS inhibitor DPI decreased the T cell proliferation and IFN-gamma production. Reactive Oxygen Species 16-19 interferon gamma Homo sapiens 73-82 20489149-6 2010 ROS production and OS were increased in IL-1alpha/IFNgamma-incubated thyrocytes and in destructive thyroiditis. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 50-58 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. Reactive Oxygen Species 31-54 interferon gamma Homo sapiens 192-208 21576359-5 2011 IFN-gamma induced progressive accumulation of reactive oxygen species (ROS) and eventual loss of mitochondrial membrane potential in cells lacking the NF-kappaB subunit RelA. Reactive Oxygen Species 46-69 interferon gamma Homo sapiens 0-9 21576359-5 2011 IFN-gamma induced progressive accumulation of reactive oxygen species (ROS) and eventual loss of mitochondrial membrane potential in cells lacking the NF-kappaB subunit RelA. Reactive Oxygen Species 71-74 interferon gamma Homo sapiens 0-9 21576359-7 2011 Overexpression of MnSOD inhibited IFN-gamma-mediated ROS accumulation and partially rescued RelA-deficient cells from necroptosis, while RNA interference (RNAi)-mediated silencing of sod2 expression increased susceptibility to IFN-gamma-induced cell death. Reactive Oxygen Species 53-56 interferon gamma Homo sapiens 34-43 21576359-8 2011 Together, these studies demonstrate that NF-kappaB protects cells from IFN-gamma-mediated necroptosis by transcriptionally activating a survival response that quenches ROS to preserve mitochondrial integrity. Reactive Oxygen Species 168-171 interferon gamma Homo sapiens 71-80 21321110-7 2011 Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors. Reactive Oxygen Species 151-174 interferon gamma Homo sapiens 56-65 20625996-0 2011 Reactive oxygen species are involved in the IFN-gamma-stimulated production of Th2 chemokines in HaCaT keratinocytes. Reactive Oxygen Species 0-23 interferon gamma Homo sapiens 44-53 20625996-3 2011 Here, we investigated the function of ROS in the production of these two Th2 chemokines in interferon-gamma (IFN-gamma)-treated HaCaT keratinocytes. Reactive Oxygen Species 38-41 interferon gamma Homo sapiens 91-107 20625996-3 2011 Here, we investigated the function of ROS in the production of these two Th2 chemokines in interferon-gamma (IFN-gamma)-treated HaCaT keratinocytes. Reactive Oxygen Species 38-41 interferon gamma Homo sapiens 109-118 20625996-4 2011 We found that IFN-gamma-induced production of both chemokines in parallel with the increased generation of intracellular ROS. Reactive Oxygen Species 121-124 interferon gamma Homo sapiens 14-23 20625996-5 2011 A ROS scavenger, N-acetyl cysteine (NAC), significantly inhibited the IFN-gamma-induced production of chemokines as well as the activation of I kappa-B (IkappaB)-nuclear factor-kappa B (NF-kappaB). Reactive Oxygen Species 2-5 interferon gamma Homo sapiens 70-79 20625996-11 2011 These results indicate that intracellular ROS and JAKs/p38 MAPK both contribute independently to IFN-gamma-stimulated production of TARC and MDC in HaCaT keratinocytes, by increasing NF-kappaB activation. Reactive Oxygen Species 42-45 interferon gamma Homo sapiens 97-106 22581042-6 2012 In particular for IFN-gamma, a significant modulatory effect on the intracellular reactive oxygen species production and phagocytic activity was observed. Reactive Oxygen Species 82-105 interferon gamma Homo sapiens 18-27 21485100-7 2011 ROS stimulates alveolar macrophages and neutrophils to release inflammatory cytokines, such as TNF-alpha, IL-8, IFN-gamma, IL-6 and IL-1beta. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 112-121 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Reactive Oxygen Species 133-156 interferon gamma Homo sapiens 13-22 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Reactive Oxygen Species 158-161 interferon gamma Homo sapiens 13-22 20483782-6 2010 We also demonstrate that IFN-gamma treatment, which is used to induce IgG2a switching, increases intracellular ROS levels, and activates p53 in switching B cells, and show that p53 inhibits IgG2a class switching through its antioxidant-regulating function. Reactive Oxygen Species 111-114 interferon gamma Homo sapiens 25-34 19088044-7 2008 MDSC-mediated immune suppression and IFN-gamma down-regulation was reversible in vitro by exposing cells to the reactive oxygen species inhibitors. Reactive Oxygen Species 112-135 interferon gamma Homo sapiens 37-46 18972195-1 2009 BACKGROUND: IL-12/23-interferon-gamma circuit enhances reactive oxygen species (ROS) synthesis in macrophage to attack intracellular pathogens such as mycobacteria and salmonella. Reactive Oxygen Species 55-78 interferon gamma Homo sapiens 21-37 18972195-1 2009 BACKGROUND: IL-12/23-interferon-gamma circuit enhances reactive oxygen species (ROS) synthesis in macrophage to attack intracellular pathogens such as mycobacteria and salmonella. Reactive Oxygen Species 80-83 interferon gamma Homo sapiens 21-37 18976633-4 2008 Our results revealed that reactive oxygen species (ROS) induced endogenous pkr gene expression at the transcriptional level by activating the interferon (IFN)-gamma gene. Reactive Oxygen Species 26-49 interferon gamma Homo sapiens 142-164 18976633-4 2008 Our results revealed that reactive oxygen species (ROS) induced endogenous pkr gene expression at the transcriptional level by activating the interferon (IFN)-gamma gene. Reactive Oxygen Species 51-54 interferon gamma Homo sapiens 142-164 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 141-150 18457828-6 2008 Exposure of cells to either IFNgamma or TNFalpha caused increased production of reactive oxygen species and transient phosphorylation of extracellular signal-regulated kinase (Erk1/2). Reactive Oxygen Species 80-103 interferon gamma Homo sapiens 28-36 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. Reactive Oxygen Species 256-259 interferon gamma Homo sapiens 100-109 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 141-150 18757424-6 2008 Furthermore, soluble TSP1 stimulates killing of breast carcinoma and melanoma cells by IFN-gamma-differentiated U937 cells in vitro via release of reactive oxygen species. Reactive Oxygen Species 147-170 interferon gamma Homo sapiens 87-96 18781914-5 2008 In macrophages, interferon-gamma also triggers the high output of reactive oxygen species, which can destroy the oxidation-labile BH4. Reactive Oxygen Species 66-89 interferon gamma Homo sapiens 16-32 17765224-8 2007 Collectively, these results demonstrate that TNF-alpha, IL-1 beta and IFN-gamma increase mitochondrial- and NADPH oxidase-generated ROS in human RPE cells. Reactive Oxygen Species 132-135 interferon gamma Homo sapiens 70-79 17765224-3 2007 We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells. Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 118-134 17765224-3 2007 We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells. Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 136-145 17765224-4 2007 TNF-alpha, IL-1 beta and IFN-gamma increased both intracellular and extracellular ROS production in a time- and dose-dependent manner. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 25-34 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 100-109