PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30261313-5 2019 However, the application of DL-Selenomethionine into T-2/HT-2 treated hepatocytes effectively alleviated the adverse effects of T-2/HT-2, as demonstrated by increased cell viability, decreased LDH leakage, declined intracellular ROS and MDA levels, increased expression of oxidative stress-related genes, as well as accordingly enhanced activities of GSH, GSH-PX, SOD and CAT as compared to the control groups (P < 0.05). Reactive Oxygen Species 229-232 brachyury 2 Mus musculus 53-56 20854872-4 2010 T-2 toxin treated animals showed time dependent increase in reactive oxygen species generation, glutathione depletion, lipid peroxidation and protein carbonyl content in brain in both the routes of exposure. Reactive Oxygen Species 60-83 brachyury 2 Mus musculus 0-3 28166479-9 2017 This is the first report in shrimp of a dose-dependent increase in ROS, SOD enzyme activity, and T-AOC at low T-2 exposures, and associated histopathological changes in the hepatopancreas, in response to dietary T-2. Reactive Oxygen Species 67-70 brachyury 2 Mus musculus 212-215 27363784-0 2016 T-2 toxin inhibits murine ES cells cardiac differentiation and mitochondrial biogenesis by ROS and p-38 MAPK-mediated pathway. Reactive Oxygen Species 91-94 brachyury 2 Mus musculus 0-3 27363784-15 2016 CONCLUSION: Taken together, T-2 toxin decreased the expression of PGC-1alpha, NRF-1, and mtTFA, inhibited mitochondrial biogenesis, and then inhibited the cardiac differentiation of murine ES cells, and the effect was partly responsible for the p38 MAPK mediated by ROS. Reactive Oxygen Species 266-269 brachyury 2 Mus musculus 28-31 22800716-0 2012 T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-kappaB-HIF-2alpha pathway. Reactive Oxygen Species 75-78 brachyury 2 Mus musculus 0-3 22800716-4 2012 To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha). Reactive Oxygen Species 146-169 brachyury 2 Mus musculus 30-33 22800716-4 2012 To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha). Reactive Oxygen Species 146-169 brachyury 2 Mus musculus 114-117 22800716-4 2012 To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha). Reactive Oxygen Species 171-174 brachyury 2 Mus musculus 30-33 22800716-4 2012 To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha). Reactive Oxygen Species 171-174 brachyury 2 Mus musculus 114-117 22800716-6 2012 Our results demonstrate that ROS-NF-kappaB-HIF-2alpha pathway participates in the effects of T-2 on hypertrophic chondrocytes, and HIF-2alpha plays an important role as a key mediator in this process. Reactive Oxygen Species 29-32 brachyury 2 Mus musculus 93-96 22614820-0 2012 T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Reactive Oxygen Species 82-105 brachyury 2 Mus musculus 0-3 22614820-8 2012 Taken together, these results demonstrate that T-2 toxin induces oxidative stress and apoptosis in differentiated murine ES cells, and ROS-mediated mitochondrial pathway plays an important role in T-2 toxin induced apoptosis. Reactive Oxygen Species 135-138 brachyury 2 Mus musculus 197-200