PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30261313-5	2019	However, the application of DL-Selenomethionine into T-2/HT-2 treated hepatocytes effectively alleviated the adverse effects of T-2/HT-2, as demonstrated by increased cell viability, decreased LDH leakage, declined intracellular ROS and MDA levels, increased expression of oxidative stress-related genes, as well as accordingly enhanced activities of GSH, GSH-PX, SOD and CAT as compared to the control groups (P < 0.05).	Reactive Oxygen Species	229-232	brachyury 2	Mus musculus	53-56	
27363784-0	2016	T-2 toxin inhibits murine ES cells cardiac differentiation and mitochondrial biogenesis by ROS and p-38 MAPK-mediated pathway.	Reactive Oxygen Species	91-94	brachyury 2	Mus musculus	0-3	
28166479-9	2017	This is the first report in shrimp of a dose-dependent increase in ROS, SOD enzyme activity, and T-AOC at low T-2 exposures, and associated histopathological changes in the hepatopancreas, in response to dietary T-2.	Reactive Oxygen Species	67-70	brachyury 2	Mus musculus	212-215	
27363784-15	2016	CONCLUSION: Taken together, T-2 toxin decreased the expression of PGC-1alpha, NRF-1, and mtTFA, inhibited mitochondrial biogenesis, and then inhibited the cardiac differentiation of murine ES cells, and the effect was partly responsible for the p38 MAPK mediated by ROS.	Reactive Oxygen Species	266-269	brachyury 2	Mus musculus	28-31	
22800716-0	2012	T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-kappaB-HIF-2alpha pathway.	Reactive Oxygen Species	75-78	brachyury 2	Mus musculus	0-3	
22800716-4	2012	To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha).	Reactive Oxygen Species	146-169	brachyury 2	Mus musculus	30-33	
22800716-4	2012	To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha).	Reactive Oxygen Species	146-169	brachyury 2	Mus musculus	114-117	
22800716-4	2012	To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha).	Reactive Oxygen Species	171-174	brachyury 2	Mus musculus	30-33	
22800716-4	2012	To uncover the mechanism that T-2 influenced metabolic homeostasis of hypertrophic chondrocytes, we observed that T-2 increased the production of reactive oxygen species (ROS) and the degradation of IkappaB-alpha, and up-regulated the expression of hypoxia-induced factor-2alpha (HIF-2alpha).	Reactive Oxygen Species	171-174	brachyury 2	Mus musculus	114-117	
22800716-6	2012	Our results demonstrate that ROS-NF-kappaB-HIF-2alpha pathway participates in the effects of T-2 on hypertrophic chondrocytes, and HIF-2alpha plays an important role as a key mediator in this process.	Reactive Oxygen Species	29-32	brachyury 2	Mus musculus	93-96	
22614820-0	2012	T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway.	Reactive Oxygen Species	82-105	brachyury 2	Mus musculus	0-3	
22614820-8	2012	Taken together, these results demonstrate that T-2 toxin induces oxidative stress and apoptosis in differentiated murine ES cells, and ROS-mediated mitochondrial pathway plays an important role in T-2 toxin induced apoptosis.	Reactive Oxygen Species	135-138	brachyury 2	Mus musculus	197-200	
20854872-4	2010	T-2 toxin treated animals showed time dependent increase in reactive oxygen species generation, glutathione depletion, lipid peroxidation and protein carbonyl content in brain in both the routes of exposure.	Reactive Oxygen Species	60-83	brachyury 2	Mus musculus	0-3