PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11675350-10	2001	In conclusion, the results of the present study suggest that CD20, CD59, and complement have a role in the in vitro cytotoxic effect of rituximab, which is mediated by a caspase-independent process that involves ROS generation.	Reactive Oxygen Species	212-215	keratin 20	Homo sapiens	61-65	
15032688-5	2004	For example, the cells derived from Fanconi anemia (FA) patients are intolerant of oxidative stress and the therapeutic effect of anti-CD20 monoclonal antibody rituximab on B cell lymphoproliferative disorders is due to the generation of ROS.	Reactive Oxygen Species	238-241	keratin 20	Homo sapiens	135-139	
24948624-0	2014	CD20 antibodies induce production and release of reactive oxygen species by neutrophils.	Reactive Oxygen Species	49-72	keratin 20	Homo sapiens	0-4	
27097113-0	2016	Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells.	Reactive Oxygen Species	0-23	keratin 20	Homo sapiens	47-51	
27097113-3	2016	The monoclonal CD20 antibodies rituximab and ofatumumab were found to trigger substantial release of ROS from monocytes.	Reactive Oxygen Species	101-104	keratin 20	Homo sapiens	15-19	
27097113-6	2016	We propose that limiting the antibody-induced induction of immunosuppressive ROS may improve the anti-leukemic efficacy of anti-CD20 therapy in CLL.	Reactive Oxygen Species	77-80	keratin 20	Homo sapiens	128-132	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	32-35	keratin 20	Homo sapiens	132-136	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	7-30	keratin 20	Homo sapiens	105-109	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	32-35	keratin 20	Homo sapiens	132-136	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	7-30	keratin 20	Homo sapiens	132-136	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	7-30	keratin 20	Homo sapiens	132-136	
24189269-11	2014	The production of all three subpopulations, the efficient ROS expelling and in vitro colony-forming activities, and the resistance to apoptosis suggested that the CD20- CD138- cell might be a candidate of CICs in WM.	Reactive Oxygen Species	58-61	keratin 20	Homo sapiens	163-167	
24189269-7	2014	Higher reactive oxygen species (ROS) expelling and in vitro colony formation activities were detected in CD20- CD138- cells than in CD20+ CD138- and CD20+ CD138+ cells.	Reactive Oxygen Species	32-35	keratin 20	Homo sapiens	105-109	
22271448-4	2012	The juxtaposition of CD20 and CD74 on MCL cells by the HexAbs resulted in homotypic adhesion and triggered intracellular changes that include loss of mitochondrial transmembrane potential, production of reactive oxygen species, rapid and sustained phosphorylation of ERKs and JNK, down-regulation of pAkt and Bcl-xL, actin reorganization, and lysosomal membrane permeabilization, culminating in cell death.	Reactive Oxygen Species	203-226	keratin 20	Homo sapiens	21-25	
22354003-4	2012	Here, we reveal that the induction of PCD by these mAbs, including the type II anti-CD20 mAb GA101 (obinutuzumab), directly correlates with their ability to produce reactive oxygen species (ROS) in human B-lymphoma cell lines and primary B-cell chronic lymphocytic leukemia cells.	Reactive Oxygen Species	165-188	keratin 20	Homo sapiens	84-88	
22354003-4	2012	Here, we reveal that the induction of PCD by these mAbs, including the type II anti-CD20 mAb GA101 (obinutuzumab), directly correlates with their ability to produce reactive oxygen species (ROS) in human B-lymphoma cell lines and primary B-cell chronic lymphocytic leukemia cells.	Reactive Oxygen Species	190-193	keratin 20	Homo sapiens	84-88	
18060882-4	2008	The kinetics of reactive oxygen species generation and changes in mitochondrial membrane potential after irradiation were also correlated with changes in CD20 expression.	Reactive Oxygen Species	16-39	keratin 20	Homo sapiens	154-158	
17972021-6	2007	Cells exposed to hypoxia generate reactive oxygen species which activate PKC zeta which in turn phosphorylates the Na,K-ATPase at the Ser18 residue in the N-terminus of the alpha1-subunit leading the ubiquitination of any of the four lysines (K16, K17, K19, K20) adjacent to the Ser18 residue.	Reactive Oxygen Species	34-57	keratin 20	Homo sapiens	258-261