PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33838689-5 2021 Both PARP1 and GAPDH were found involved in the hub network of protein-protein interaction (PPI) of potential targets and were found to take part in many bioprocesses, including responding to the regulation of reactive oxygen species (ROS) metabolic process, apoptotic signaling pathway, and response to oxygen levels through enrichment analysis. Reactive Oxygen Species 210-233 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 15-20 34216695-7 2021 The silencing of the expression of GAPDH pre-knockdown was found to reduce the intracellular levels of ROS and lipid peroxidation, enhance autophagy activity, thereby reducing the cell injury, apoptosis and necrosis induced by exogenous alpha-synuclein protein in SH-SY5Y cells. Reactive Oxygen Species 103-106 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 35-40 35562998-1 2022 Oxidation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by reactive oxygen species such as H2O2 activate pleiotropic signaling pathways is associated with pathophysiological cell fate decisions. Reactive Oxygen Species 65-88 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 13-53 35562998-1 2022 Oxidation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by reactive oxygen species such as H2O2 activate pleiotropic signaling pathways is associated with pathophysiological cell fate decisions. Reactive Oxygen Species 65-88 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 55-60 33838689-5 2021 Both PARP1 and GAPDH were found involved in the hub network of protein-protein interaction (PPI) of potential targets and were found to take part in many bioprocesses, including responding to the regulation of reactive oxygen species (ROS) metabolic process, apoptotic signaling pathway, and response to oxygen levels through enrichment analysis. Reactive Oxygen Species 235-238 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 15-20 29780883-6 2016 reported that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) through an ROS-dependent mechanism. Reactive Oxygen Species 160-163 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 100-140 32536603-9 2020 Sensitivity of GAPDH to reactive oxygen species (ROS) has been described previously in microbes and here, we present GAPDH as an immediate, primary target of IR-induced oxidation across all domains of life. Reactive Oxygen Species 24-47 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 15-20 32536603-9 2020 Sensitivity of GAPDH to reactive oxygen species (ROS) has been described previously in microbes and here, we present GAPDH as an immediate, primary target of IR-induced oxidation across all domains of life. Reactive Oxygen Species 24-47 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 117-122 32536603-9 2020 Sensitivity of GAPDH to reactive oxygen species (ROS) has been described previously in microbes and here, we present GAPDH as an immediate, primary target of IR-induced oxidation across all domains of life. Reactive Oxygen Species 49-52 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 15-20 32536603-9 2020 Sensitivity of GAPDH to reactive oxygen species (ROS) has been described previously in microbes and here, we present GAPDH as an immediate, primary target of IR-induced oxidation across all domains of life. Reactive Oxygen Species 49-52 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 117-122 29780883-6 2016 reported that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) through an ROS-dependent mechanism. Reactive Oxygen Species 160-163 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 142-147 26541605-5 2015 Thus, reactive oxygen species accumulate and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Reactive Oxygen Species 6-29 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 56-96 26541605-5 2015 Thus, reactive oxygen species accumulate and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Reactive Oxygen Species 6-29 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 98-103 26255116-3 2015 Within 3h of the addition of oxLDL, there was a rapid, concentration dependent rise in cellular reactive oxygen species followed by the loss of cellular GSH, and the enzyme activity of both glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and aconitase. Reactive Oxygen Species 96-119 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 232-237 25019091-5 2014 The elevated levels of both NADH and ROS can inhibit and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH), respectively, resulting in blockage of the glycolytic pathway and accumulation of glycerol 3-phospate and its prior metabolites along the pathway. Reactive Oxygen Species 37-40 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 68-108 26255202-6 2015 Exogenous GAPDS protein can diminish ROS content in sperms and promote sperm motility at the concentration of over 5 ug/ml GAPDS. Reactive Oxygen Species 37-40 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 10-15 26255202-7 2015 Based on the literature data on the importance of GAPDS for the motility of sperms in diabetic men, it was concluded that the decrease in the sperm motility and GAPDS activity in the presence of high glucose or diabetes mellitus is due to oxidation of GAPDS and inhibition of glycolysis by the reactive oxygen species produced by sperms. Reactive Oxygen Species 294-317 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 161-166 26255202-7 2015 Based on the literature data on the importance of GAPDS for the motility of sperms in diabetic men, it was concluded that the decrease in the sperm motility and GAPDS activity in the presence of high glucose or diabetes mellitus is due to oxidation of GAPDS and inhibition of glycolysis by the reactive oxygen species produced by sperms. Reactive Oxygen Species 294-317 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 161-166 24769698-1 2014 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Reactive Oxygen Species 147-170 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 24769698-1 2014 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Reactive Oxygen Species 147-170 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 42-47 24769698-1 2014 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Reactive Oxygen Species 172-175 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 24769698-1 2014 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Reactive Oxygen Species 172-175 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 42-47 25019091-5 2014 The elevated levels of both NADH and ROS can inhibit and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH), respectively, resulting in blockage of the glycolytic pathway and accumulation of glycerol 3-phospate and its prior metabolites along the pathway. Reactive Oxygen Species 37-40 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 110-115 19016472-6 2009 Furthermore, PEG-mediated ROS induction caused nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase and an increase in caspase-3 activity, confirming a link with apoptosis. Reactive Oxygen Species 26-29 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 72-112 23124112-0 2013 UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells. Reactive Oxygen Species 25-28 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 64-69 22006949-7 2011 GAPDH knockdown depleted bioenergetic and antioxidant enzymes and elevated hepatocyte ROS, whereas GAPDH overexpression decreased hepatocyte ROS. Reactive Oxygen Species 86-89 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 22006949-7 2011 GAPDH knockdown depleted bioenergetic and antioxidant enzymes and elevated hepatocyte ROS, whereas GAPDH overexpression decreased hepatocyte ROS. Reactive Oxygen Species 141-144 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 99-104 21568861-5 2011 Based on the literature data on the importance of GAPDS for the motility of sperms together with the presented observations, it was concluded that the decrease in the sperm motility in the presence of reactive oxygen species is due to the oxidation of GAPDS and inhibition of glycolysis. Reactive Oxygen Species 201-224 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 50-55 21568861-5 2011 Based on the literature data on the importance of GAPDS for the motility of sperms together with the presented observations, it was concluded that the decrease in the sperm motility in the presence of reactive oxygen species is due to the oxidation of GAPDS and inhibition of glycolysis. Reactive Oxygen Species 201-224 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 252-257 23124112-3 2013 We also show that UCP2 inhibition triggers ROS-dependent nuclear translocation of the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH), formation of autophagosomes, and the expression of the autophagy marker LC3-II. Reactive Oxygen Species 43-46 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 146-151 12623164-5 2003 Mitochondrial reactive oxygen species (ROS) partially inhibit the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, which diverts increased substrate flux from glycolysis to pathways of glucose overutilization. Reactive Oxygen Species 14-37 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 85-125 15950210-4 2005 In a previous study of quinone toxicity, this quinone, whose actions have been exclusively attributed to reactive oxygen species (ROS) generation, caused a reduction in the glycolytic activity of GAPDH under aerobic and anaerobic conditions, indicating indirect and possible direct actions on this enzyme. Reactive Oxygen Species 105-128 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 196-201 15950210-4 2005 In a previous study of quinone toxicity, this quinone, whose actions have been exclusively attributed to reactive oxygen species (ROS) generation, caused a reduction in the glycolytic activity of GAPDH under aerobic and anaerobic conditions, indicating indirect and possible direct actions on this enzyme. Reactive Oxygen Species 130-133 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 196-201 17055214-7 2007 An in vitro experiment demonstrated that GAPDH was highly susceptible to reactive oxygen species generated in the xanthine-xanthine oxidase system, whereas thioredoxin reductase was considerably resistant. Reactive Oxygen Species 73-96 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 41-46 15950210-11 2005 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Reactive Oxygen Species 65-68 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 23-28 15950210-11 2005 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Reactive Oxygen Species 65-68 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 115-120 15950210-11 2005 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Reactive Oxygen Species 65-68 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 115-120 12623164-5 2003 Mitochondrial reactive oxygen species (ROS) partially inhibit the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, which diverts increased substrate flux from glycolysis to pathways of glucose overutilization. Reactive Oxygen Species 39-42 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 85-125 12480546-8 2003 Our data suggested that high glucose induced mitochondrial ROS, which suppressed first-phase of GIIS, at least in part, through the suppression of GAPDH activity. Reactive Oxygen Species 59-62 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 147-152 12506084-11 2003 WS proteins from aged human lens generate reactive oxygen species (ROS) during UVA irradiation, which may be responsible for the inactivation of G3PD. Reactive Oxygen Species 42-65 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 145-149 12506084-11 2003 WS proteins from aged human lens generate reactive oxygen species (ROS) during UVA irradiation, which may be responsible for the inactivation of G3PD. Reactive Oxygen Species 67-70 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 145-149 11245448-4 2001 The ratio between oxidized and reduced glulathione and the oxidation-dependent inactivation of glyceraldehyde-3phosphate dehydrogenase (GAPDH) are considered independent markers of cellular reactive oxygen species homeostasis and redox state. Reactive Oxygen Species 190-213 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 95-134