PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29491408-3 2018 Downregulation of tuberin (protein encoded by TSC2 gene) in renal proximal tubular epithelial cells significantly increased ROS concomitant with enhanced Nox4. Reactive Oxygen Species 124-127 TSC complex subunit 2 Mus musculus 18-25 29491408-3 2018 Downregulation of tuberin (protein encoded by TSC2 gene) in renal proximal tubular epithelial cells significantly increased ROS concomitant with enhanced Nox4. Reactive Oxygen Species 124-127 TSC complex subunit 2 Mus musculus 46-50 30508035-7 2019 Intra-glomerular reactive oxygen species (ROS) levels measured by dihydroethidium florescence showed significant increases in ROS production in irradiated Tsc2+/- mice compared with non-irradiated animals. Reactive Oxygen Species 17-40 TSC complex subunit 2 Mus musculus 155-159 30508035-7 2019 Intra-glomerular reactive oxygen species (ROS) levels measured by dihydroethidium florescence showed significant increases in ROS production in irradiated Tsc2+/- mice compared with non-irradiated animals. Reactive Oxygen Species 42-45 TSC complex subunit 2 Mus musculus 155-159 30508035-7 2019 Intra-glomerular reactive oxygen species (ROS) levels measured by dihydroethidium florescence showed significant increases in ROS production in irradiated Tsc2+/- mice compared with non-irradiated animals. Reactive Oxygen Species 126-129 TSC complex subunit 2 Mus musculus 155-159 20160076-0 2010 ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Reactive Oxygen Species 71-74 TSC complex subunit 2 Mus musculus 15-19 20160076-7 2010 Our results identify a cytoplasmic pathway for ROS-induced ATM activation of TSC2 to regulate mTORC1 signaling and autophagy, identifying an integration node for the cellular damage response with key pathways involved in metabolism, protein synthesis, and cell survival. Reactive Oxygen Species 47-50 TSC complex subunit 2 Mus musculus 77-81