PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25489418-9	2014	Overall, our study demonstrates firstly that arsenite acutely decreases NO production at least in part by increasing eNOS-Thr(497) phosphorylation via ROS-PP1 signaling pathway, which provide the molecular mechanism underlying arsenite-induced increase in vascular disease.	Reactive Oxygen Species	151-154	nitric oxide synthase 3	Bos taurus	117-121	
25489418-5	2014	Treatment with arsenite also induced reactive oxygen species (ROS) production, and pretreatment with a ROS scavenger N-acetyl-L-cysteine (NAC) completely reversed the observed effect of arsenite on eNOS-Thr(497) phosphorylation.	Reactive Oxygen Species	103-106	nitric oxide synthase 3	Bos taurus	198-202	
9839278-0	1998	CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1.	Reactive Oxygen Species	51-74	nitric oxide synthase 3	Bos taurus	26-30	
10400908-0	1999	Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae.	Reactive Oxygen Species	20-43	nitric oxide synthase 3	Bos taurus	63-96	
10400908-9	1999	In vitro exposure of caveolae-enriched membranes to ROS (xanthine plus xanthine oxidase) dissociated caveolin more readily than eNOS from the membranes.	Reactive Oxygen Species	52-55	nitric oxide synthase 3	Bos taurus	128-132	
10400908-10	1999	These results show that cholesterol treatment increases eNOS expression, whereas ROS treatment decreases eNOS expression and the association of eNOS with caveolin in caveolae-enriched membranes.	Reactive Oxygen Species	81-84	nitric oxide synthase 3	Bos taurus	105-109	
10400908-10	1999	These results show that cholesterol treatment increases eNOS expression, whereas ROS treatment decreases eNOS expression and the association of eNOS with caveolin in caveolae-enriched membranes.	Reactive Oxygen Species	81-84	nitric oxide synthase 3	Bos taurus	105-109	
9839278-4	1998	The ROS generating system glucose oxidase (GO) increased the expression of eNOS mRNA in BAEC.	Reactive Oxygen Species	4-7	nitric oxide synthase 3	Bos taurus	75-79	
9839278-8	1998	The potential participation of ROS and the transcription factor AP-1 in the regulation of eNOS gene expression is suggested.	Reactive Oxygen Species	31-34	nitric oxide synthase 3	Bos taurus	90-94	
9647467-0	1998	Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells.	Reactive Oxygen Species	8-31	nitric oxide synthase 3	Bos taurus	102-106	
9647467-3	1998	As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS.	Reactive Oxygen Species	217-220	nitric oxide synthase 3	Bos taurus	150-154	
9647467-7	1998	Two ROS generating systems, xanthine plus xanthine oxidase (XXO) and glucose oxidase (GO), increased the expression of eNOS mRNA in BAEC, an effect which was maximal after 8 h of incubation (XXO: 168+/-21% of control values.	Reactive Oxygen Species	4-7	nitric oxide synthase 3	Bos taurus	119-123	
9647467-9	1998	The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity.	Reactive Oxygen Species	4-7	nitric oxide synthase 3	Bos taurus	28-32	
9647467-9	1998	The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity.	Reactive Oxygen Species	4-7	nitric oxide synthase 3	Bos taurus	80-84	
9647467-17	1998	The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation.	Reactive Oxygen Species	39-42	nitric oxide synthase 3	Bos taurus	129-133