PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10400908-0 1999 Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Reactive Oxygen Species 20-43 nitric oxide synthase 3 Bos taurus 63-96 25489418-5 2014 Treatment with arsenite also induced reactive oxygen species (ROS) production, and pretreatment with a ROS scavenger N-acetyl-L-cysteine (NAC) completely reversed the observed effect of arsenite on eNOS-Thr(497) phosphorylation. Reactive Oxygen Species 103-106 nitric oxide synthase 3 Bos taurus 198-202 25489418-9 2014 Overall, our study demonstrates firstly that arsenite acutely decreases NO production at least in part by increasing eNOS-Thr(497) phosphorylation via ROS-PP1 signaling pathway, which provide the molecular mechanism underlying arsenite-induced increase in vascular disease. Reactive Oxygen Species 151-154 nitric oxide synthase 3 Bos taurus 117-121 10400908-9 1999 In vitro exposure of caveolae-enriched membranes to ROS (xanthine plus xanthine oxidase) dissociated caveolin more readily than eNOS from the membranes. Reactive Oxygen Species 52-55 nitric oxide synthase 3 Bos taurus 128-132 10400908-10 1999 These results show that cholesterol treatment increases eNOS expression, whereas ROS treatment decreases eNOS expression and the association of eNOS with caveolin in caveolae-enriched membranes. Reactive Oxygen Species 81-84 nitric oxide synthase 3 Bos taurus 105-109 10400908-10 1999 These results show that cholesterol treatment increases eNOS expression, whereas ROS treatment decreases eNOS expression and the association of eNOS with caveolin in caveolae-enriched membranes. Reactive Oxygen Species 81-84 nitric oxide synthase 3 Bos taurus 105-109 9839278-0 1998 CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1. Reactive Oxygen Species 51-74 nitric oxide synthase 3 Bos taurus 26-30 9839278-4 1998 The ROS generating system glucose oxidase (GO) increased the expression of eNOS mRNA in BAEC. Reactive Oxygen Species 4-7 nitric oxide synthase 3 Bos taurus 75-79 9839278-8 1998 The potential participation of ROS and the transcription factor AP-1 in the regulation of eNOS gene expression is suggested. Reactive Oxygen Species 31-34 nitric oxide synthase 3 Bos taurus 90-94 9647467-0 1998 Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells. Reactive Oxygen Species 8-31 nitric oxide synthase 3 Bos taurus 102-106 9647467-3 1998 As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS. Reactive Oxygen Species 217-220 nitric oxide synthase 3 Bos taurus 150-154 9647467-7 1998 Two ROS generating systems, xanthine plus xanthine oxidase (XXO) and glucose oxidase (GO), increased the expression of eNOS mRNA in BAEC, an effect which was maximal after 8 h of incubation (XXO: 168+/-21% of control values. Reactive Oxygen Species 4-7 nitric oxide synthase 3 Bos taurus 119-123 9647467-9 1998 The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity. Reactive Oxygen Species 4-7 nitric oxide synthase 3 Bos taurus 28-32 9647467-9 1998 The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity. Reactive Oxygen Species 4-7 nitric oxide synthase 3 Bos taurus 80-84 9647467-17 1998 The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation. Reactive Oxygen Species 39-42 nitric oxide synthase 3 Bos taurus 129-133