PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27391159-0 2016 Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion. Reactive Oxygen Species 51-74 gelsolin Homo sapiens 0-8 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 3-26 gelsolin Homo sapiens 121-129 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 3-26 gelsolin Homo sapiens 247-255 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 3-26 gelsolin Homo sapiens 247-255 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 28-31 gelsolin Homo sapiens 121-129 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 28-31 gelsolin Homo sapiens 247-255 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 28-31 gelsolin Homo sapiens 247-255 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 149-152 gelsolin Homo sapiens 121-129 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 149-152 gelsolin Homo sapiens 247-255 27391159-3 2016 As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that gelsolin-induced changes in ROS levels may mediate the invasive capacity of colon cancer cells.Herein, we show that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin"s effects in elevating intracellular superoxide (O2.-) levels. Reactive Oxygen Species 149-152 gelsolin Homo sapiens 247-255 24724551-6 2014 Light irradiation stimulated ROS-dependent actin polymerization, and this effect was abrogated by PBP10, a peptide which activates the actin-severing protein, gelsolin, and causes actin-depolymerization in human sperm. Reactive Oxygen Species 29-32 gelsolin Homo sapiens 159-167 15625007-5 2004 RESULTS: We report that a cell permeable ten amino acid peptide (PBP10) derived from the phosphatidylinositol 4,5-bisphosphate (PIP2) binding region of gelsolin (an uncapper of actin filaments) blocks granule mobilization as well as secretion of oxygen radicals. Reactive Oxygen Species 246-261 gelsolin Homo sapiens 152-160