PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16527992-4 2006 In this study, we hypothesized that ROS-induced CyPA secretion from VSMC requires a highly regulated process of vesicle transport, docking, and fusion at the plasma membrane. Reactive Oxygen Species 36-39 peptidylprolyl isomerase A Homo sapiens 48-52 11055983-3 2000 Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Reactive Oxygen Species 227-250 peptidylprolyl isomerase A Homo sapiens 25-38 12207006-3 2002 For this study, we investigated mechanisms of CsA toxicity during AMT and showed that a high level of reactive oxygen species (ROS) generated by CsA, mediated partly by inhibition of the peptidylprolyl-cis-trans-isomerase (PPIase)-like activity of cyclophilin A (CypA), blocked differentiation and induced apoptosis at an early stage of muscle differentiation. Reactive Oxygen Species 102-125 peptidylprolyl isomerase A Homo sapiens 248-261 12207006-3 2002 For this study, we investigated mechanisms of CsA toxicity during AMT and showed that a high level of reactive oxygen species (ROS) generated by CsA, mediated partly by inhibition of the peptidylprolyl-cis-trans-isomerase (PPIase)-like activity of cyclophilin A (CypA), blocked differentiation and induced apoptosis at an early stage of muscle differentiation. Reactive Oxygen Species 102-125 peptidylprolyl isomerase A Homo sapiens 263-267 12207006-3 2002 For this study, we investigated mechanisms of CsA toxicity during AMT and showed that a high level of reactive oxygen species (ROS) generated by CsA, mediated partly by inhibition of the peptidylprolyl-cis-trans-isomerase (PPIase)-like activity of cyclophilin A (CypA), blocked differentiation and induced apoptosis at an early stage of muscle differentiation. Reactive Oxygen Species 127-130 peptidylprolyl isomerase A Homo sapiens 248-261 12207006-3 2002 For this study, we investigated mechanisms of CsA toxicity during AMT and showed that a high level of reactive oxygen species (ROS) generated by CsA, mediated partly by inhibition of the peptidylprolyl-cis-trans-isomerase (PPIase)-like activity of cyclophilin A (CypA), blocked differentiation and induced apoptosis at an early stage of muscle differentiation. Reactive Oxygen Species 127-130 peptidylprolyl isomerase A Homo sapiens 263-267 11055983-3 2000 Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Reactive Oxygen Species 227-250 peptidylprolyl isomerase A Homo sapiens 40-44 34852234-4 2021 Furthermore, CypA reduces cellular reactive oxygen species levels and increases CRC cell survival under insults of H2O2 and chemotherapeutics through a CypA-PRDX2-mediated antioxidant apparatus. Reactive Oxygen Species 35-58 peptidylprolyl isomerase A Homo sapiens 13-17 34852234-4 2021 Furthermore, CypA reduces cellular reactive oxygen species levels and increases CRC cell survival under insults of H2O2 and chemotherapeutics through a CypA-PRDX2-mediated antioxidant apparatus. Reactive Oxygen Species 35-58 peptidylprolyl isomerase A Homo sapiens 152-156 23846495-2 2013 Cyclophilin A (CyPA) is a ubiquitously expressed cytosolic protein that possesses peptidyl-prolyl cis-trans isomerase activity, scaffold function, and significantly enhances AngII-induced ROS production in VSMC. Reactive Oxygen Species 188-191 peptidylprolyl isomerase A Homo sapiens 0-13 35579671-0 2022 Cyclophilin A represses reactive oxygen species generation and death of hypoxic non-small-cell lung cancer cells by degrading thioredoxin-interacting protein. Reactive Oxygen Species 24-47 peptidylprolyl isomerase A Homo sapiens 0-13 35579671-9 2022 Overexpression of cypA restored hypoxia-impaired cell growth and prevented reactive oxygen species (ROS) production and cell death in hypoxic A549 and H1299 cells. Reactive Oxygen Species 75-98 peptidylprolyl isomerase A Homo sapiens 18-22 35579671-9 2022 Overexpression of cypA restored hypoxia-impaired cell growth and prevented reactive oxygen species (ROS) production and cell death in hypoxic A549 and H1299 cells. Reactive Oxygen Species 100-103 peptidylprolyl isomerase A Homo sapiens 18-22 35579671-12 2022 Restored TXNIP expression in cypA-overexpressed and hypoxic NSCLC cells led to increased ROS levels and apoptotic cell numbers and decreased cell growth compared with cypA-overexpressed and hypoxic NSCLC cells. Reactive Oxygen Species 89-92 peptidylprolyl isomerase A Homo sapiens 29-33 33393627-2 2021 Cyclophilin A (CypA), a member of the immunophilin family, is secreted in response to ROS. Reactive Oxygen Species 86-89 peptidylprolyl isomerase A Homo sapiens 0-13 33393627-2 2021 Cyclophilin A (CypA), a member of the immunophilin family, is secreted in response to ROS. Reactive Oxygen Species 86-89 peptidylprolyl isomerase A Homo sapiens 15-19 33393627-5 2021 Our results demonstrated that hCypA substantially promoted cell viability, superoxide dismutase (SOD), glutathione (GSH), and GSH peroxidase (GSH-Px) activities, and attenuated ROS and malondialdehyde (MDA) production in H2O2-induced A549 cells. Reactive Oxygen Species 177-180 peptidylprolyl isomerase A Homo sapiens 30-35 31182989-3 2019 Cyclophilin A (CyPA) is a major ROS-induced factor in atherosclerosis. Reactive Oxygen Species 32-35 peptidylprolyl isomerase A Homo sapiens 0-13 31182989-3 2019 Cyclophilin A (CyPA) is a major ROS-induced factor in atherosclerosis. Reactive Oxygen Species 32-35 peptidylprolyl isomerase A Homo sapiens 15-19 31182989-4 2019 There is a positive feedback mechanism between CyPA and ROS, which enables the oxidative stress response to continue and expand. Reactive Oxygen Species 56-59 peptidylprolyl isomerase A Homo sapiens 47-51 31182989-7 2019 By dihydroethidium (DHE) staining and electron spin resonance (ESR) assays, we demonstrated that CyPA reduced ROS production and suppressed O2 - production dependent on reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Reactive Oxygen Species 110-113 peptidylprolyl isomerase A Homo sapiens 97-101 24406688-7 2014 Furthermore, cyclophilin A (CyPA) has been shown to be secreted from vascular smooth muscle cells and to augment the destructive effects of ROS, linking it to the development of many cardiovascular diseases. Reactive Oxygen Species 140-143 peptidylprolyl isomerase A Homo sapiens 13-26 24406688-7 2014 Furthermore, cyclophilin A (CyPA) has been shown to be secreted from vascular smooth muscle cells and to augment the destructive effects of ROS, linking it to the development of many cardiovascular diseases. Reactive Oxygen Species 140-143 peptidylprolyl isomerase A Homo sapiens 28-32 23846495-2 2013 Cyclophilin A (CyPA) is a ubiquitously expressed cytosolic protein that possesses peptidyl-prolyl cis-trans isomerase activity, scaffold function, and significantly enhances AngII-induced ROS production in VSMC. Reactive Oxygen Species 188-191 peptidylprolyl isomerase A Homo sapiens 15-19 23846495-3 2013 We hypothesized that CyPA regulates AngII-induced ROS generation by promoting translocation of NADPH oxidase cytosolic subunit p47phox to caveolae of the plasma membrane. Reactive Oxygen Species 50-53 peptidylprolyl isomerase A Homo sapiens 21-25 23846495-4 2013 APPROACH AND RESULTS: Overexpression of CyPA in CyPA-deficient VSMC (CyPA(-/-)VSMC) significantly increased AngII-stimulated ROS production. Reactive Oxygen Species 125-128 peptidylprolyl isomerase A Homo sapiens 40-44 23846495-4 2013 APPROACH AND RESULTS: Overexpression of CyPA in CyPA-deficient VSMC (CyPA(-/-)VSMC) significantly increased AngII-stimulated ROS production. Reactive Oxygen Species 125-128 peptidylprolyl isomerase A Homo sapiens 48-52 23846495-4 2013 APPROACH AND RESULTS: Overexpression of CyPA in CyPA-deficient VSMC (CyPA(-/-)VSMC) significantly increased AngII-stimulated ROS production. Reactive Oxygen Species 125-128 peptidylprolyl isomerase A Homo sapiens 48-52 23846495-5 2013 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors (VAS2870 or diphenylene iodonium) significantly attenuated AngII-induced ROS production in CyPA and p47phox-overexpressing CyPA(-/-)VSMC. Reactive Oxygen Species 144-147 peptidylprolyl isomerase A Homo sapiens 162-166 23846495-5 2013 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors (VAS2870 or diphenylene iodonium) significantly attenuated AngII-induced ROS production in CyPA and p47phox-overexpressing CyPA(-/-)VSMC. Reactive Oxygen Species 144-147 peptidylprolyl isomerase A Homo sapiens 194-198 23846495-12 2013 CONCLUSIONS: These findings provide the mechanism by which CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae. Reactive Oxygen Species 108-111 peptidylprolyl isomerase A Homo sapiens 59-63 23180369-3 2013 Cyclophilin A (CyPA) is the main reactive oxygen species-induced factor that enhances the inflammatory activity of vascular cells in atherosclerotic plaques. Reactive Oxygen Species 33-56 peptidylprolyl isomerase A Homo sapiens 0-13 23180369-3 2013 Cyclophilin A (CyPA) is the main reactive oxygen species-induced factor that enhances the inflammatory activity of vascular cells in atherosclerotic plaques. Reactive Oxygen Species 33-56 peptidylprolyl isomerase A Homo sapiens 15-19 23180369-7 2013 This study shows that CyPA may initiate antiapoptotic and proapoptotic signaling in ECs, especially in response to reactive oxygen species stimulation. Reactive Oxygen Species 115-138 peptidylprolyl isomerase A Homo sapiens 22-26 23940449-2 2013 In atherosclerosis, various cells, including endothelial cells, monocytes, vascular smooth muscle cells and platelets, secrete CypA in response to excessive levels of reactive oxygen species. Reactive Oxygen Species 167-190 peptidylprolyl isomerase A Homo sapiens 127-131 17440077-5 2007 Interestingly, overexpression of CypA prevented hypoxia- and cisplatin-induced apoptosis, and this was associated with the suppression of reactive oxygen species generation and depolarization of mitochondrial membrane potential, whereas small interfering RNA-based CypA knockdown aggravated these factors. Reactive Oxygen Species 138-161 peptidylprolyl isomerase A Homo sapiens 33-37 21035802-2 2010 Cyclophilin A (CyPA) is the main ROS-induced factor that enhances the inflammatory activity of monocytes/macrophages in atherosclerotic plaque. Reactive Oxygen Species 33-36 peptidylprolyl isomerase A Homo sapiens 0-13 21035802-2 2010 Cyclophilin A (CyPA) is the main ROS-induced factor that enhances the inflammatory activity of monocytes/macrophages in atherosclerotic plaque. Reactive Oxygen Species 33-36 peptidylprolyl isomerase A Homo sapiens 15-19 21035802-8 2010 The current study shows that CyPA-EMMPRIN interaction is one of the key pro-inflammatory signaling pathways in monocytes, perhaps especially in response to ROS stimulation. Reactive Oxygen Species 156-159 peptidylprolyl isomerase A Homo sapiens 29-33 20195816-10 2010 Antioxidant effects of CypA, which have been suggested by some researchers, may also become critical to reactive oxygen species (ROS) creating an oncogenetic environment. Reactive Oxygen Species 104-127 peptidylprolyl isomerase A Homo sapiens 23-27 20195816-10 2010 Antioxidant effects of CypA, which have been suggested by some researchers, may also become critical to reactive oxygen species (ROS) creating an oncogenetic environment. Reactive Oxygen Species 129-132 peptidylprolyl isomerase A Homo sapiens 23-27