PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21537829-5 2011 We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions. Reactive Oxygen Species 147-170 dynamin 1-like Mus musculus 207-212 21537829-5 2011 We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions. Reactive Oxygen Species 147-170 dynamin 1-like Mus musculus 234-239 21537829-5 2011 We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions. Reactive Oxygen Species 172-175 dynamin 1-like Mus musculus 207-212 21537829-5 2011 We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions. Reactive Oxygen Species 172-175 dynamin 1-like Mus musculus 234-239 33895866-6 2021 Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616. Reactive Oxygen Species 14-37 dynamin 1-like Mus musculus 131-156 33895866-6 2021 Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616. Reactive Oxygen Species 39-42 dynamin 1-like Mus musculus 131-156 33895866-6 2021 Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616. Reactive Oxygen Species 39-42 dynamin 1-like Mus musculus 157-161 33895866-6 2021 Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616. Reactive Oxygen Species 14-37 dynamin 1-like Mus musculus 157-161 27802433-1 2016 BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. Reactive Oxygen Species 75-98 dynamin 1-like Mus musculus 31-36 32493171-10 2020 Pharmacological inhibition or knockdown of Drp1 decreased the mitochondrial reactive oxygen species and chemotactic activity in cultured macrophages. Reactive Oxygen Species 76-99 dynamin 1-like Mus musculus 43-47 31358548-3 2019 A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission. Reactive Oxygen Species 51-74 dynamin 1-like Mus musculus 116-141 31358548-3 2019 A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission. Reactive Oxygen Species 51-74 dynamin 1-like Mus musculus 143-147 31358548-3 2019 A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission. Reactive Oxygen Species 76-79 dynamin 1-like Mus musculus 116-141 31358548-3 2019 A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission. Reactive Oxygen Species 76-79 dynamin 1-like Mus musculus 143-147 28849115-8 2017 Inhibition of Drp1 activity by Mdivi-1 efficiently prevented Abeta-42-induced ROS production and disruption of mitochondrial membrane potential. Reactive Oxygen Species 78-81 dynamin 1-like Mus musculus 14-18 31168914-8 2019 Mechanistically, CGA attenuates ROS-induced mitochondrial fragmentation by inhibiting dynamin-related protein 1 (Drp1) and enhancing Mfn2 expression. Reactive Oxygen Species 32-35 dynamin 1-like Mus musculus 86-111 31168914-8 2019 Mechanistically, CGA attenuates ROS-induced mitochondrial fragmentation by inhibiting dynamin-related protein 1 (Drp1) and enhancing Mfn2 expression. Reactive Oxygen Species 32-35 dynamin 1-like Mus musculus 113-117 27802433-7 2016 RESULTS: Inhibition of Drp1 and Dynamin 2 protected against mitochondrial fragmentation, maintained DeltaPsim, attenuated cellular ROS production and limited apoptosis. Reactive Oxygen Species 131-134 dynamin 1-like Mus musculus 23-27 27802433-10 2016 CONCLUSIONS: Oxidative stress-induced apoptosis and ROS production are attenuated by not only Drp1 inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes. Reactive Oxygen Species 52-55 dynamin 1-like Mus musculus 94-98 27802433-1 2016 BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. Reactive Oxygen Species 100-103 dynamin 1-like Mus musculus 31-36 25599491-2 2015 Dynamin-related protein 1, a regulator of mitochondrial fission, is an important determinant of reactive oxygen species generation, myocardial necrosis, and left ventricular function following ischemia/reperfusion injury, but its role in cardiac arrest is unknown. Reactive Oxygen Species 96-119 dynamin 1-like Mus musculus 0-25 23919963-8 2013 Finally, mechanistic study further suggested that decreased Drp1 level by rhein might be due to its effect on reducing cellular reactive oxygen species. Reactive Oxygen Species 128-151 dynamin 1-like Mus musculus 60-64 23815397-7 2013 Interestingly, inhibition of LPS-induced mitochondrial fission and reactive oxygen species (ROS) generation by Mdivi-1 and Drp1 knock-down attenuated the production of pro-inflammatory mediators via reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling. Reactive Oxygen Species 67-90 dynamin 1-like Mus musculus 123-127 23815397-7 2013 Interestingly, inhibition of LPS-induced mitochondrial fission and reactive oxygen species (ROS) generation by Mdivi-1 and Drp1 knock-down attenuated the production of pro-inflammatory mediators via reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling. Reactive Oxygen Species 92-95 dynamin 1-like Mus musculus 123-127