PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28377599-4	2017	On the contrary, ozone (abundant component of air NTP) treatment alone, exhibited the highest levels of reactive oxygen species production leading to CypD-related necrosis via the mitochondrial permeability transition.	Reactive Oxygen Species	104-127	peptidylprolyl isomerase D	Homo sapiens	150-154	
33309700-8	2021	In the matrix these peptides, which would fold into alpha-helical structure in native conditions, interact with cyclophilin D (CypD) and upon stimulation by elevated ROS and/or the Ca2+ spontaneously misfold into beta-sheet ion conducting pores, causing PTP opening.	Reactive Oxygen Species	166-169	peptidylprolyl isomerase D	Homo sapiens	127-131	
29541521-5	2018	Our data demonstrate that high dose laser irradiation exhibited the highest levels of total reactive oxygen species production, leading to cyclophilin D-related necrosis via the mitochondrial permeability transition.	Reactive Oxygen Species	92-115	peptidylprolyl isomerase D	Homo sapiens	139-152	
28273124-8	2017	And the protective effects of blocking CypD in Dex-induced gingival fibroblasts dysfunction were evidenced by rescued mitochondrial function and suppressed production of reactive oxygen species (ROS).	Reactive Oxygen Species	170-193	peptidylprolyl isomerase D	Homo sapiens	39-43	
28273124-8	2017	And the protective effects of blocking CypD in Dex-induced gingival fibroblasts dysfunction were evidenced by rescued mitochondrial function and suppressed production of reactive oxygen species (ROS).	Reactive Oxygen Species	195-198	peptidylprolyl isomerase D	Homo sapiens	39-43	
28273124-9	2017	In addition, blockade of CypD by pharmaceutical inhibitor CsA or gene knockdown also restored Dex-induced cell toxicity in HGF-1 cells, as shown by suppressed mitochondrial ROS production, increased CcO activity and decreased apoptosis.	Reactive Oxygen Species	173-176	peptidylprolyl isomerase D	Homo sapiens	25-29	
23382999-7	2013	The potential mechanisms of the protective effects of lacking CypD on Abeta-induced abnormal mitochondrial transport in axon are increased axonal calcium buffer capability, diminished reactive oxygen species (ROS), and suppressing downstream signal transduction P38 activation.	Reactive Oxygen Species	209-212	peptidylprolyl isomerase D	Homo sapiens	62-66	
28351946-0	2017	Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production.	Reactive Oxygen Species	117-120	peptidylprolyl isomerase D	Homo sapiens	82-95	
28351946-8	2017	Binding of STAT3 to CypD was mediated by the amino terminus of STAT3, which was also important for reducing mitochondrial ROS production after oxidative stress.	Reactive Oxygen Species	122-125	peptidylprolyl isomerase D	Homo sapiens	20-24	
23195208-0	2012	Cyclophilin D: a therapeutic target to counteract reactive oxygen species-mediated damage in neurodegenerative disease?	Reactive Oxygen Species	50-73	peptidylprolyl isomerase D	Homo sapiens	0-13