PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19833897-11 2010 This effect is mediated by ROS-induced methylglyoxal, the major substrate of glyoxalase 1. Reactive Oxygen Species 27-30 glyoxalase 1 Mus musculus 77-89 28170200-3 2017 The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces ROS in D-ADSCs, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of CLI. Reactive Oxygen Species 144-147 glyoxalase 1 Mus musculus 109-121 28170200-3 2017 The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces ROS in D-ADSCs, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of CLI. Reactive Oxygen Species 144-147 glyoxalase 1 Mus musculus 123-127 28170200-11 2017 The results of the present study have demonstrated that protection from ROS accumulation by GLO1 overexpression is effective in reversing the impaired biological function of D-ADSCs in promoting neovascularization of diabetic CLI mice model and warrants the future clinical application of D-ADSC-based therapy in diabetic patients. Reactive Oxygen Species 72-75 glyoxalase 1 Mus musculus 92-96