PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32498290-4 2020 HTT did not show any cytotoxicity, and it further illustrated the potential to increase cell viability by reducing the reactive oxygen species (ROS) production in FD-stimulated keratinocytes. Reactive Oxygen Species 119-142 huntingtin Homo sapiens 0-3 11978772-0 2002 Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Reactive Oxygen Species 94-117 huntingtin Homo sapiens 128-138 32498555-5 2021 Mutant huntingtin (mHTT) can directly interact with mitochondrial proteins, as translocase of the inner membrane 23 (TIM23), disrupting mitochondrial proteostasis and favoring ROS production and HD progression. Reactive Oxygen Species 176-179 huntingtin Homo sapiens 7-17 11978772-8 2002 However, we observed that mutant huntingtin caused increased levels of ROS in neuronal and non-neuronal cells. Reactive Oxygen Species 71-74 huntingtin Homo sapiens 33-43 11978772-10 2002 HSP27 decreased ROS in cells expressing mutant huntingtin, suggesting that this chaperone protects cells against oxidative stress. Reactive Oxygen Species 16-19 huntingtin Homo sapiens 47-57 32498290-4 2020 HTT did not show any cytotoxicity, and it further illustrated the potential to increase cell viability by reducing the reactive oxygen species (ROS) production in FD-stimulated keratinocytes. Reactive Oxygen Species 144-147 huntingtin Homo sapiens 0-3 30632085-8 2019 Further, excessive accumulation of the HTT gene repeats causes abnormal production of reactive oxygen species (ROS) and the ensuing mitochondrial (MT) oxidative stress in neurons. Reactive Oxygen Species 86-109 huntingtin Homo sapiens 39-42 30632085-8 2019 Further, excessive accumulation of the HTT gene repeats causes abnormal production of reactive oxygen species (ROS) and the ensuing mitochondrial (MT) oxidative stress in neurons. Reactive Oxygen Species 111-114 huntingtin Homo sapiens 39-42 30538129-0 2019 High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry. Reactive Oxygen Species 43-66 huntingtin Homo sapiens 70-80 30538129-3 2019 Huntingtin is normally retained at the endoplasmic reticulum via its N17 amphipathic alpha-helix domain but is released by oxidation of Met-8 during reactive oxygen species (ROS) stress. Reactive Oxygen Species 149-172 huntingtin Homo sapiens 0-10 30538129-3 2019 Huntingtin is normally retained at the endoplasmic reticulum via its N17 amphipathic alpha-helix domain but is released by oxidation of Met-8 during reactive oxygen species (ROS) stress. Reactive Oxygen Species 174-177 huntingtin Homo sapiens 0-10 30538129-7 2019 We also found that HMGB1 interacts with the huntingtin N17 region and that this interaction is enhanced by the presence of ROS and phosphorylation of critical serine residues in the N17 region. Reactive Oxygen Species 123-126 huntingtin Homo sapiens 44-54 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 50-53 huntingtin Homo sapiens 28-38 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 50-53 huntingtin Homo sapiens 143-153 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 128-131 huntingtin Homo sapiens 28-38 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 128-131 huntingtin Homo sapiens 143-153 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 128-131 huntingtin Homo sapiens 28-38 30538129-8 2019 We conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress. Reactive Oxygen Species 128-131 huntingtin Homo sapiens 143-153 28733489-5 2017 beta-Amyloid, tau, alpha-synuclein and huntingtin are shown to be involved in increased production of reactive oxygen species, which can be generated in mitochondria or can target this organelle. Reactive Oxygen Species 102-125 huntingtin Homo sapiens 39-49 21984825-5 2011 Live imaging of cells expressing a fragment of huntingtin (httExon1) with a poly(Q) expansion shows increased ROS production preceding cell death. Reactive Oxygen Species 110-113 huntingtin Homo sapiens 47-57 20491647-2 2010 Mutated Htt (mHtt) causes the appearance of intracellular aggregates inducing alterations in mitochondrial metabolism in the form of reactive oxygen species (ROS) and ATP depletion. Reactive Oxygen Species 133-156 huntingtin Homo sapiens 8-11 20491647-2 2010 Mutated Htt (mHtt) causes the appearance of intracellular aggregates inducing alterations in mitochondrial metabolism in the form of reactive oxygen species (ROS) and ATP depletion. Reactive Oxygen Species 158-161 huntingtin Homo sapiens 8-11 16817855-1 2006 We recently reported that the transient expression of polyglutamine tracts of various size in exon 1 of the huntingtin polypeptide (httEx1) generated abnormally high levels of intracellular reactive oxygen species that directly contributed to cell death. Reactive Oxygen Species 190-213 huntingtin Homo sapiens 108-118 30256717-6 2018 We additionally observed dysregulated reactive oxygen species (ROS)-dependent huntingtin localization to nuclear speckles in HD cells. Reactive Oxygen Species 38-61 huntingtin Homo sapiens 78-88 30256717-6 2018 We additionally observed dysregulated reactive oxygen species (ROS)-dependent huntingtin localization to nuclear speckles in HD cells. Reactive Oxygen Species 63-66 huntingtin Homo sapiens 78-88