PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30412932-4 2019 However, the FlgE-induced neutrophils recruitment, neutrophils reactive oxygen species (ROS) generation, and neutrophil extracellular traps (NETs) formation were significantly impaired in Il17a-/- mice compared with those in wild-type (WT) mice. Reactive Oxygen Species 63-86 interleukin 17A Mus musculus 188-193 31190552-0 2020 Excessive Reactive Oxygen Species Inhibit IL-17A+ gammadelta T Cells and Innate Cellular Responses to Bacterial Lung Infection. Reactive Oxygen Species 10-33 interleukin 17A Mus musculus 42-48 31396305-4 2019 Methods and Results: Chronic IL-17A overexpression in T cells (CD4-IL-17Aind/+ mice) resulted in elevated reactive oxygen species in the peripheral blood and a significant vascular dysfunction compared to control mice. Reactive Oxygen Species 106-129 interleukin 17A Mus musculus 29-35 30412932-4 2019 However, the FlgE-induced neutrophils recruitment, neutrophils reactive oxygen species (ROS) generation, and neutrophil extracellular traps (NETs) formation were significantly impaired in Il17a-/- mice compared with those in wild-type (WT) mice. Reactive Oxygen Species 88-91 interleukin 17A Mus musculus 188-193 27034404-1 2016 IL-6 and IL-23 (IL-6/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. Reactive Oxygen Species 174-197 interleukin 17A Mus musculus 32-38 29613836-9 2018 IL-17 increased mitochondrial dysfunction and ROS accumulation, which was related to autophagy induction. Reactive Oxygen Species 46-49 interleukin 17A Mus musculus 0-5 29021374-8 2017 Furthermore, treatment of NKT cells with antioxidants led to reduced frequencies of IFN-gamma- and IL-17-expressing cells, indicating that ROS play a role in regulating the inflammatory function of NKT cells. Reactive Oxygen Species 139-142 interleukin 17A Mus musculus 99-104 27389701-7 2016 Furthermore, ROS appears to be responsible for elevated IL-17A levels and subsequently exaggerated inflammatory response. Reactive Oxygen Species 13-16 interleukin 17A Mus musculus 56-62 27389701-9 2016 Our findings reveal a previously undemonstrated function for AnxA2 in inflammatory response in polymicrobial sepsis models via an AnxA2-ROS-IL-17 axis, providing insight into the regulation of pathophysiology of sepsis. Reactive Oxygen Species 136-139 interleukin 17A Mus musculus 140-145 27034404-1 2016 IL-6 and IL-23 (IL-6/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. Reactive Oxygen Species 174-197 interleukin 17A Mus musculus 32-37 22798682-6 2012 Mitochondrial ROS augmented the expression of B cell-activating transcription factor, which may contribute to increased IL-17 production in the absence of IEX-1, in light of its importance in IL-17 transcription. Reactive Oxygen Species 14-17 interleukin 17A Mus musculus 120-125 23505509-1 2013 IL-17A induces the release of pro-inflammatory cytokines and of reactive oxygen species which could lead to neutrophilic inflammation. Reactive Oxygen Species 64-87 interleukin 17A Mus musculus 0-6 25341795-3 2014 APPROACH AND RESULTS: Conditional overexpression of IL-17A in keratinocytes caused severe psoriasis-like skin inflammation in mice (K14-IL-17A(ind/+) mice), associated with increased reactive oxygen species formation and circulating CD11b(+) inflammatory leukocytes in blood, with endothelial dysfunction, increased systolic blood pressure, left ventricular hypertrophy, and reduced survival compared with controls. Reactive Oxygen Species 183-206 interleukin 17A Mus musculus 52-58 24045154-3 2013 ROS production led to the Syk-, Pyk2-, and mitogen-activated protein kinase (MAPK)-dependent production of the proinflammatory cytokine interleukin-17A (IL-17A) in a manner that required the transcription factor CREB (cyclic adenosine monophosphate response element-binding protein). Reactive Oxygen Species 0-3 interleukin 17A Mus musculus 136-151 24045154-3 2013 ROS production led to the Syk-, Pyk2-, and mitogen-activated protein kinase (MAPK)-dependent production of the proinflammatory cytokine interleukin-17A (IL-17A) in a manner that required the transcription factor CREB (cyclic adenosine monophosphate response element-binding protein). Reactive Oxygen Species 0-3 interleukin 17A Mus musculus 153-159 22798682-6 2012 Mitochondrial ROS augmented the expression of B cell-activating transcription factor, which may contribute to increased IL-17 production in the absence of IEX-1, in light of its importance in IL-17 transcription. Reactive Oxygen Species 14-17 interleukin 17A Mus musculus 192-197 20606471-0 2011 Pro-inflammatory effects of interleukin-17A on vascular smooth muscle cells involve NAD(P)H- oxidase derived reactive oxygen species. Reactive Oxygen Species 109-132 interleukin 17A Mus musculus 28-43 22207130-0 2012 IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Reactive Oxygen Species 108-111 interleukin 17A Mus musculus 0-5 22207130-5 2012 RESULTS: We found that treatment with IL-17 and IL-22 causes an increase in IL-1beta via the activation of NLRP3 by a process that involves the generation of reactive oxygen species. Reactive Oxygen Species 158-181 interleukin 17A Mus musculus 38-43 22191467-2 2012 Dysregulation of the L-tryptophan metabolism in mice with defects in NADPH oxidase, resulting in overproduction of interleukin (IL)-17, has been proposed to link ROS defects with hyperinflammation and susceptibility to pulmonary aspergillosis. Reactive Oxygen Species 162-165 interleukin 17A Mus musculus 115-134 20606471-8 2011 Taken together, our data indicate that IL-17A causes the NAD(P)H-oxidase dependent generation of ROS leading to a pro-inflammatory activation of VSMC. Reactive Oxygen Species 97-100 interleukin 17A Mus musculus 39-45 20606471-6 2011 The p38-MAPK inhibitors SB203580 and SB202190 dose-dependently reduced the IL-17A induced ROS production. Reactive Oxygen Species 90-93 interleukin 17A Mus musculus 75-81 18383034-5 2008 DC deficient in ROS production induced high levels of IFN-gamma and IL-17 in responding T cells after Ag-specific or superantigen-induced activation. Reactive Oxygen Species 16-19 interleukin 17A Mus musculus 68-73 19940258-6 2010 IL-17A induced NADPH oxidase- or xanthine oxidase-dependent reactive oxygen species (ROS) production. Reactive Oxygen Species 60-83 interleukin 17A Mus musculus 0-6 19940258-6 2010 IL-17A induced NADPH oxidase- or xanthine oxidase-dependent reactive oxygen species (ROS) production. Reactive Oxygen Species 85-88 interleukin 17A Mus musculus 0-6 19940258-8 2010 Blocking either ROS formation or myosin light chain phosphorylation or applying IL-17A-neutralizing antibodies prevented IL-17A-induced BBB disruption. Reactive Oxygen Species 16-19 interleukin 17A Mus musculus 121-127