PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20962773-0 2011 Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin. Reactive Oxygen Species 0-23 LOC100508689 Homo sapiens 81-86 25704757-7 2015 HG activates MMP-9 production, MMP-9 activity and MUC5AC overproduction, which is inhibited by nPG, DMSO and DPI (inhibitors of ROS and NADPH), suggesting that HG-activated mucin synthesis is mediated by NADPH/ROS in 16HBE cells. Reactive Oxygen Species 210-213 LOC100508689 Homo sapiens 173-178 21229383-3 2011 Many studies have shown that overexpression of reactive oxygen species (ROS) and nuclear factor-kappaB (NF-kappaB) leads to increased mucin (MUC) 5AC expression in chronic inflammation of the airway. Reactive Oxygen Species 47-70 LOC100508689 Homo sapiens 134-139 21229383-3 2011 Many studies have shown that overexpression of reactive oxygen species (ROS) and nuclear factor-kappaB (NF-kappaB) leads to increased mucin (MUC) 5AC expression in chronic inflammation of the airway. Reactive Oxygen Species 47-70 LOC100508689 Homo sapiens 141-144 21229383-3 2011 Many studies have shown that overexpression of reactive oxygen species (ROS) and nuclear factor-kappaB (NF-kappaB) leads to increased mucin (MUC) 5AC expression in chronic inflammation of the airway. Reactive Oxygen Species 72-75 LOC100508689 Homo sapiens 134-139 21229383-3 2011 Many studies have shown that overexpression of reactive oxygen species (ROS) and nuclear factor-kappaB (NF-kappaB) leads to increased mucin (MUC) 5AC expression in chronic inflammation of the airway. Reactive Oxygen Species 72-75 LOC100508689 Homo sapiens 141-144 26608927-3 2016 The excessive production of ROS can trigger an inflammatory response and mucin hypersecretion by enhancing the transcriptional activity of pro-inflammatory cytokines and mucin genes. Reactive Oxygen Species 28-31 LOC100508689 Homo sapiens 73-78 26608927-3 2016 The excessive production of ROS can trigger an inflammatory response and mucin hypersecretion by enhancing the transcriptional activity of pro-inflammatory cytokines and mucin genes. Reactive Oxygen Species 28-31 LOC100508689 Homo sapiens 170-175 21255638-3 2011 We investigated the mechanism of ROS generation and its association with mucin gene overexpression in the nasal epithelium. Reactive Oxygen Species 33-36 LOC100508689 Homo sapiens 73-78 20724237-7 2010 In this investigation, we demonstrate that NE-induced mucin production requires reactive oxygen species (ROS) production, which activates TACE, resulting in TGF-alpha shedding, and EGFR phosphorylation in NCI-H292 epithelial cells. Reactive Oxygen Species 80-103 LOC100508689 Homo sapiens 54-59 20709182-10 2011 These results suggest that the AhR-induced increase of mucin production is partially mediated by ROS generation. Reactive Oxygen Species 97-100 LOC100508689 Homo sapiens 55-60 20724237-7 2010 In this investigation, we demonstrate that NE-induced mucin production requires reactive oxygen species (ROS) production, which activates TACE, resulting in TGF-alpha shedding, and EGFR phosphorylation in NCI-H292 epithelial cells. Reactive Oxygen Species 105-108 LOC100508689 Homo sapiens 54-59 19051307-4 2009 Microscopy combined with assays for the neutrophil releases of reactive oxygen species and human neutrophil lipocalin showed that mucin precoating greatly reduced the strong immune-response normally induced by adsorbed immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA), respectively. Reactive Oxygen Species 63-86 LOC100508689 Homo sapiens 130-135 18073139-0 2008 Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. Reactive Oxygen Species 0-23 LOC100508689 Homo sapiens 90-95 18925363-2 2009 Here, using the release of reactive oxygen species (ROS) as a marker of material-induced neutrophil activation, the strong surface-passivating effects of these mucin coatings were corroborated. Reactive Oxygen Species 27-50 LOC100508689 Homo sapiens 160-165 18925363-2 2009 Here, using the release of reactive oxygen species (ROS) as a marker of material-induced neutrophil activation, the strong surface-passivating effects of these mucin coatings were corroborated. Reactive Oxygen Species 52-55 LOC100508689 Homo sapiens 160-165 18073139-0 2008 Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. Reactive Oxygen Species 129-132 LOC100508689 Homo sapiens 90-95 18073139-4 2008 Here, we report that the bacterium P. aeruginosa, an important human respiratory pathogen causing cystic fibrosis, utilizes reactive oxygen species (ROS) to up-regulate MUC5AC mucin expression. Reactive Oxygen Species 124-147 LOC100508689 Homo sapiens 176-181 18073139-4 2008 Here, we report that the bacterium P. aeruginosa, an important human respiratory pathogen causing cystic fibrosis, utilizes reactive oxygen species (ROS) to up-regulate MUC5AC mucin expression. Reactive Oxygen Species 149-152 LOC100508689 Homo sapiens 176-181 16148149-3 2005 Previous studies showed that HNE induces MUC5AC mucin production involving reactive oxygen species (ROS) generation and TGF-alpha-dependent epidermal growth factor receptor (EGFR) activation in human airway epithelial cells. Reactive Oxygen Species 75-98 LOC100508689 Homo sapiens 48-53 17664143-7 2007 Mucins were susceptible to ROS attack, causing loss of terminal sugars and protein and mucin fragmentation. Reactive Oxygen Species 27-30 LOC100508689 Homo sapiens 87-92 17664143-12 2007 As native mucus gel is more resistant to ROS damage than purified mucin, nonmucin components of mucus may have extensive ROS-scavenging properties. Reactive Oxygen Species 121-124 LOC100508689 Homo sapiens 66-71 16148149-10 2005 We conclude that HNE induces MUC5AC mucin expression via a cascade involving PKC-ROS-TACE in human airway epithelial cells. Reactive Oxygen Species 81-84 LOC100508689 Homo sapiens 36-41 16148149-3 2005 Previous studies showed that HNE induces MUC5AC mucin production involving reactive oxygen species (ROS) generation and TGF-alpha-dependent epidermal growth factor receptor (EGFR) activation in human airway epithelial cells. Reactive Oxygen Species 100-103 LOC100508689 Homo sapiens 48-53 15640347-2 2005 MUC5AC mucin is a major component of airway mucus, and its expression is modulated by a TNF-alpha-converting enzyme (TACE)-EGF receptor pathway that can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 169-192 LOC100508689 Homo sapiens 7-12 15640347-6 2005 These stimuli induced TACE activation, TGF-alpha release, and mucin expression, effects that were inhibited by ROS scavengers, implicating ROS in TACE activation. Reactive Oxygen Species 139-142 LOC100508689 Homo sapiens 62-67 15640347-2 2005 MUC5AC mucin is a major component of airway mucus, and its expression is modulated by a TNF-alpha-converting enzyme (TACE)-EGF receptor pathway that can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 194-197 LOC100508689 Homo sapiens 7-12 15640347-6 2005 These stimuli induced TACE activation, TGF-alpha release, and mucin expression, effects that were inhibited by ROS scavengers, implicating ROS in TACE activation. Reactive Oxygen Species 111-114 LOC100508689 Homo sapiens 62-67 15640347-9 2005 From these results, we conclude that Duox1 plays a critical role in mucin expression by airway epithelial cells through PKCdelta/PKC-Duox1-ROS-TACE-pro-ligand-EGF receptor cascade. Reactive Oxygen Species 139-142 LOC100508689 Homo sapiens 68-73 33810420-7 2021 Among the tested formulations, only mucin-hyalurosomes were capable of effectively counteracting the production of reactive oxygen species (ROS) induced by cigarette smoke extract, suggesting that this formulation may represent a promising tool to reduce the damaging effects of cigarette smoke in the lung tissues, thus reducing the pathogenesis of cigarette smoke-associated diseases such as chronic obstructive pulmonary disease, emphysema, and cancer. Reactive Oxygen Species 115-138 LOC100508689 Homo sapiens 36-41 15121636-7 2004 Furthermore, pretreatment with antioxidants prevents smoking-induced TGF-alpha shedding and mucin production, suggesting that reactive oxygen species is involved in TACE activation. Reactive Oxygen Species 126-149 LOC100508689 Homo sapiens 92-97 8944730-2 1996 We investigated mechanisms of ROS-induced mucin secretion by guinea pig tracheal epithelial (GPTE) cells in primary culture, and ROS-induced activation of the second messenger-producing enzyme phospholipase C (PLC), in GPTE cells and in a virally transformed cell line (BEAS-2B) derived from human bronchial epithelium. Reactive Oxygen Species 30-33 LOC100508689 Homo sapiens 42-47 8944730-4 1996 ROS generated enzymatically by xanthine oxidase (XO, 500 microM) in the presence of purine (500 microM) enhanced release of mucin by GPTE cells and activated PLC in GPTE and BEAS cells. Reactive Oxygen Species 0-3 LOC100508689 Homo sapiens 124-129 33810420-7 2021 Among the tested formulations, only mucin-hyalurosomes were capable of effectively counteracting the production of reactive oxygen species (ROS) induced by cigarette smoke extract, suggesting that this formulation may represent a promising tool to reduce the damaging effects of cigarette smoke in the lung tissues, thus reducing the pathogenesis of cigarette smoke-associated diseases such as chronic obstructive pulmonary disease, emphysema, and cancer. Reactive Oxygen Species 140-143 LOC100508689 Homo sapiens 36-41