PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	85-108	CD40 ligand	Mus musculus	46-51	
19895673-1	2010	OBJECTIVES: CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully.	Reactive Oxygen Species	69-92	CD40 ligand	Mus musculus	12-23	
19895673-1	2010	OBJECTIVES: CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully.	Reactive Oxygen Species	69-92	CD40 ligand	Mus musculus	25-30	
19895673-1	2010	OBJECTIVES: CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully.	Reactive Oxygen Species	94-97	CD40 ligand	Mus musculus	12-23	
19895673-1	2010	OBJECTIVES: CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully.	Reactive Oxygen Species	94-97	CD40 ligand	Mus musculus	25-30	
19895673-4	2010	CD40L exposure also stimulated the GTPase Rac1, which is known to activate NADPH oxidases, and enhanced ROS formation, whereas PI3K inhibition or depletion by small interfering RNA (siRNA) prevented these responses.	Reactive Oxygen Species	104-107	CD40 ligand	Mus musculus	0-5	
19895673-8	2010	Importantly, PI3K inhibition prevented CD40L-mediated ROS generation and endothelial dysfunction in a mouse model.	Reactive Oxygen Species	54-57	CD40 ligand	Mus musculus	39-44	
19895673-9	2010	In summary, PI3K mediates CD40L-induced ROS production and subsequent endothelial dysfunction.	Reactive Oxygen Species	40-43	CD40 ligand	Mus musculus	26-31	
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	85-108	CD40 ligand	Mus musculus	178-183	
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	85-108	CD40 ligand	Mus musculus	178-183	
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	110-113	CD40 ligand	Mus musculus	46-51	
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	110-113	CD40 ligand	Mus musculus	178-183	
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	110-113	CD40 ligand	Mus musculus	178-183