PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27040799-14 2016 Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis. Reactive Oxygen Species 52-55 proline dehydrogenase 1 Homo sapiens 25-30 28264926-6 2017 Furthermore, ectopic expression of wild-type PRODH, but not enzymatically inactive forms, induced senescence associated with the increase in reactive oxygen species (ROS) and the accumulation of DNA damage. Reactive Oxygen Species 141-164 proline dehydrogenase 1 Homo sapiens 45-50 28264926-6 2017 Furthermore, ectopic expression of wild-type PRODH, but not enzymatically inactive forms, induced senescence associated with the increase in reactive oxygen species (ROS) and the accumulation of DNA damage. Reactive Oxygen Species 166-169 proline dehydrogenase 1 Homo sapiens 45-50 28264926-7 2017 Treatment with N-acetyl-L-cysteine, a ROS scavenger, prevented senescence induced by PRODH overexpression. Reactive Oxygen Species 38-41 proline dehydrogenase 1 Homo sapiens 85-90 28264926-8 2017 These results indicate that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of ROS. Reactive Oxygen Species 126-129 proline dehydrogenase 1 Homo sapiens 28-33 27040799-14 2016 Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis. Reactive Oxygen Species 52-55 proline dehydrogenase 1 Homo sapiens 31-34 26660760-5 2016 Effects on respiratory fitness were inhibited by DHP and NAC, indicating that these effects were mediated by PRODH/POX-dependent reactive oxygen species (ROS) generation. Reactive Oxygen Species 129-152 proline dehydrogenase 1 Homo sapiens 109-114 26660760-5 2016 Effects on respiratory fitness were inhibited by DHP and NAC, indicating that these effects were mediated by PRODH/POX-dependent reactive oxygen species (ROS) generation. Reactive Oxygen Species 129-152 proline dehydrogenase 1 Homo sapiens 115-118 26660760-7 2016 We found that succinate was an uncompetitive inhibitor of PRODH/POX activity, inhibited ROS generation by PRODH/POX, and alleviated PRODH/POX effects on respiratory fitness. Reactive Oxygen Species 88-91 proline dehydrogenase 1 Homo sapiens 106-111 26660760-7 2016 We found that succinate was an uncompetitive inhibitor of PRODH/POX activity, inhibited ROS generation by PRODH/POX, and alleviated PRODH/POX effects on respiratory fitness. Reactive Oxygen Species 88-91 proline dehydrogenase 1 Homo sapiens 112-115 26660760-5 2016 Effects on respiratory fitness were inhibited by DHP and NAC, indicating that these effects were mediated by PRODH/POX-dependent reactive oxygen species (ROS) generation. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 109-114 26660760-7 2016 We found that succinate was an uncompetitive inhibitor of PRODH/POX activity, inhibited ROS generation by PRODH/POX, and alleviated PRODH/POX effects on respiratory fitness. Reactive Oxygen Species 88-91 proline dehydrogenase 1 Homo sapiens 106-111 26660760-7 2016 We found that succinate was an uncompetitive inhibitor of PRODH/POX activity, inhibited ROS generation by PRODH/POX, and alleviated PRODH/POX effects on respiratory fitness. Reactive Oxygen Species 88-91 proline dehydrogenase 1 Homo sapiens 112-115 26660760-5 2016 Effects on respiratory fitness were inhibited by DHP and NAC, indicating that these effects were mediated by PRODH/POX-dependent reactive oxygen species (ROS) generation. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 115-118 20562915-1 2010 Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling. Reactive Oxygen Species 143-166 proline dehydrogenase 1 Homo sapiens 0-15 22796327-3 2012 PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. Reactive Oxygen Species 78-101 proline dehydrogenase 1 Homo sapiens 0-5 22201764-3 2012 ProDH is not only essential for proline catabolism but also plays key roles in providing energy, shuttling redox potential between cellular compartments and reactive oxygen species production. Reactive Oxygen Species 157-180 proline dehydrogenase 1 Homo sapiens 0-5 26330555-12 2015 Inhibition of POX activity by a competitive inhibitor "dehydroproline" decreased ROS levels concomitant with reduced neuronal autophagy. Reactive Oxygen Species 81-84 proline dehydrogenase 1 Homo sapiens 14-17 26330555-13 2015 Conversely, overexpression of POX in neuronal cells increased ROS levels and activated ROS-dependent autophagy. Reactive Oxygen Species 62-65 proline dehydrogenase 1 Homo sapiens 30-33 26330555-13 2015 Conversely, overexpression of POX in neuronal cells increased ROS levels and activated ROS-dependent autophagy. Reactive Oxygen Species 87-90 proline dehydrogenase 1 Homo sapiens 30-33 22885468-7 2012 Interestingly, under hypoxia PRODH/POX induces protective autophagy by generating reactive oxygen species (ROS). Reactive Oxygen Species 82-105 proline dehydrogenase 1 Homo sapiens 29-34 22885468-7 2012 Interestingly, under hypoxia PRODH/POX induces protective autophagy by generating reactive oxygen species (ROS). Reactive Oxygen Species 82-105 proline dehydrogenase 1 Homo sapiens 35-38 22885468-7 2012 Interestingly, under hypoxia PRODH/POX induces protective autophagy by generating reactive oxygen species (ROS). Reactive Oxygen Species 107-110 proline dehydrogenase 1 Homo sapiens 29-34 22885468-7 2012 Interestingly, under hypoxia PRODH/POX induces protective autophagy by generating reactive oxygen species (ROS). Reactive Oxygen Species 107-110 proline dehydrogenase 1 Homo sapiens 35-38 22609800-1 2012 Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. Reactive Oxygen Species 115-138 proline dehydrogenase 1 Homo sapiens 74-89 22609800-1 2012 Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. Reactive Oxygen Species 115-138 proline dehydrogenase 1 Homo sapiens 91-94 22609800-1 2012 Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. Reactive Oxygen Species 140-143 proline dehydrogenase 1 Homo sapiens 91-94 22609800-7 2012 Under low-glucose and combined low-glucose and hypoxic conditions, proline catabolized by POX was used preferentially for ATP production, whereas under hypoxia, POX mediated autophagic signaling for survival by generating ROS. Reactive Oxygen Species 222-225 proline dehydrogenase 1 Homo sapiens 90-93 22609800-7 2012 Under low-glucose and combined low-glucose and hypoxic conditions, proline catabolized by POX was used preferentially for ATP production, whereas under hypoxia, POX mediated autophagic signaling for survival by generating ROS. Reactive Oxygen Species 222-225 proline dehydrogenase 1 Homo sapiens 161-164 20562915-1 2010 Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling. Reactive Oxygen Species 143-166 proline dehydrogenase 1 Homo sapiens 17-20 20562915-1 2010 Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling. Reactive Oxygen Species 168-171 proline dehydrogenase 1 Homo sapiens 0-15 20562915-1 2010 Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling. Reactive Oxygen Species 168-171 proline dehydrogenase 1 Homo sapiens 17-20 20562915-7 2010 Consistent with the POX-mediated tumor suppression pathway, these antagomirs induced ROS, inhibited HIF signaling and increased apoptosis. Reactive Oxygen Species 85-88 proline dehydrogenase 1 Homo sapiens 20-23 18287100-8 2008 Therefore, we hypothesize that OH-POX plays a role analogous to POX in growth regulation, ROS generation, and activation of the apoptotic cascade. Reactive Oxygen Species 90-93 proline dehydrogenase 1 Homo sapiens 34-37 19942609-0 2010 Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Reactive Oxygen Species 73-76 proline dehydrogenase 1 Homo sapiens 45-60 19942609-6 2010 To elucidate the role of POX in oxLDL-mediated cytotoxicity, we knocked down POX via small interfering RNA and found that this (i) further reduced viability of cancer cells treated with oxLDL; (ii) decreased oxLDL-associated reactive oxygen species generation; (iii) decreased autophagy measured via beclin-1 protein level and light-chain 3 protein (LC3)-I into LC3-II conversion. Reactive Oxygen Species 225-248 proline dehydrogenase 1 Homo sapiens 77-80 18794809-2 2008 POX is markedly elevated during p53-induced apoptosis and generates proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, to induce apoptosis through both mitochondrial and death receptor pathways. Reactive Oxygen Species 86-109 proline dehydrogenase 1 Homo sapiens 0-3 18794809-2 2008 POX is markedly elevated during p53-induced apoptosis and generates proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, to induce apoptosis through both mitochondrial and death receptor pathways. Reactive Oxygen Species 111-114 proline dehydrogenase 1 Homo sapiens 0-3 18401543-3 2008 proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen species for programmed cell death. Reactive Oxygen Species 132-155 proline dehydrogenase 1 Homo sapiens 27-32 16619034-0 2006 Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. Reactive Oxygen Species 91-94 proline dehydrogenase 1 Homo sapiens 0-15 17535976-0 2007 Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Reactive Oxygen Species 156-179 proline dehydrogenase 1 Homo sapiens 132-147 17535976-5 2007 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species 0-23 proline dehydrogenase 1 Homo sapiens 84-99 17535976-5 2007 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species 0-23 proline dehydrogenase 1 Homo sapiens 101-104 17535976-5 2007 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species 25-28 proline dehydrogenase 1 Homo sapiens 84-99 17535976-5 2007 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species 25-28 proline dehydrogenase 1 Homo sapiens 101-104 17535976-6 2007 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species 57-60 proline dehydrogenase 1 Homo sapiens 0-3 17535976-6 2007 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species 57-60 proline dehydrogenase 1 Homo sapiens 105-108 17535976-6 2007 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 0-3 17535976-6 2007 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 105-108 17535976-8 2007 The results of the present study suggest that PPARgamma activation induces apoptotic cell death in non-small-cell lung carcinoma mainly through ROS formation via POX induction. Reactive Oxygen Species 144-147 proline dehydrogenase 1 Homo sapiens 162-165 16874462-2 2007 Previously we showed that overexpression of POX is associated with generation of reactive oxygen species (ROS) and apoptosis in POX-inducible colorectal cancer cells, DLD-1.POX. Reactive Oxygen Species 81-104 proline dehydrogenase 1 Homo sapiens 44-47 16874462-2 2007 Previously we showed that overexpression of POX is associated with generation of reactive oxygen species (ROS) and apoptosis in POX-inducible colorectal cancer cells, DLD-1.POX. Reactive Oxygen Species 106-109 proline dehydrogenase 1 Homo sapiens 44-47 16874462-3 2007 We also showed expression of mitochondrial MnSOD partially blunts POX-induced ROS generation and apoptosis. Reactive Oxygen Species 78-81 proline dehydrogenase 1 Homo sapiens 66-69 16619034-9 2006 These findings suggest the involvement of MEK/ERK signaling and further confirm the role of ROS/superoxides in POX-induced apoptosis. Reactive Oxygen Species 92-95 proline dehydrogenase 1 Homo sapiens 111-114 16619034-2 2006 We have shown that POX generated proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the mitochondrial (intrinsic) pathway. Reactive Oxygen Species 51-74 proline dehydrogenase 1 Homo sapiens 19-22 16619034-2 2006 We have shown that POX generated proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the mitochondrial (intrinsic) pathway. Reactive Oxygen Species 76-79 proline dehydrogenase 1 Homo sapiens 19-22 16303758-2 2006 We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS). Reactive Oxygen Species 105-128 proline dehydrogenase 1 Homo sapiens 30-33 16303758-9 2006 A time- and dose-dependent increase in POX catalytic activity was obtained in HCT116 cells treated with troglitazone with a concomitant increase in the production of intracellular ROS. Reactive Oxygen Species 180-183 proline dehydrogenase 1 Homo sapiens 39-42 16303758-10 2006 Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 116-119 16303758-10 2006 Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms. Reactive Oxygen Species 154-157 proline dehydrogenase 1 Homo sapiens 161-164 16303758-2 2006 We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS). Reactive Oxygen Species 130-133 proline dehydrogenase 1 Homo sapiens 30-33 11280728-4 2001 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Reactive Oxygen Species 59-82 proline dehydrogenase 1 Homo sapiens 20-23 15817612-2 2005 Previously, we showed that POX catalyzed the generation of reactive oxygen species (ROS). Reactive Oxygen Species 59-82 proline dehydrogenase 1 Homo sapiens 27-30 15817612-2 2005 Previously, we showed that POX catalyzed the generation of reactive oxygen species (ROS). Reactive Oxygen Species 84-87 proline dehydrogenase 1 Homo sapiens 27-30 11280728-8 2001 Again, we found a proline-dependent ROS increase with POX expression. Reactive Oxygen Species 36-39 proline dehydrogenase 1 Homo sapiens 54-57 11280728-9 2001 We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX. Reactive Oxygen Species 65-68 proline dehydrogenase 1 Homo sapiens 198-201 11280728-4 2001 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Reactive Oxygen Species 84-87 proline dehydrogenase 1 Homo sapiens 20-23 11280728-7 2001 To confirm that the observed ROS production was not secondary to some other effect of p53, we also conditionally expressed POX in a p53-negative colon cancer line. Reactive Oxygen Species 29-32 proline dehydrogenase 1 Homo sapiens 123-126 34682765-4 2021 PRODH/POX degrades proline yielding reactive oxygen species (ROS). Reactive Oxygen Species 36-59 proline dehydrogenase 1 Homo sapiens 0-5 34682765-4 2021 PRODH/POX degrades proline yielding reactive oxygen species (ROS). Reactive Oxygen Species 36-59 proline dehydrogenase 1 Homo sapiens 6-9 34682765-4 2021 PRODH/POX degrades proline yielding reactive oxygen species (ROS). Reactive Oxygen Species 61-64 proline dehydrogenase 1 Homo sapiens 0-5 34682765-4 2021 PRODH/POX degrades proline yielding reactive oxygen species (ROS). Reactive Oxygen Species 61-64 proline dehydrogenase 1 Homo sapiens 6-9 35163433-4 2022 PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated. Reactive Oxygen Species 92-115 proline dehydrogenase 1 Homo sapiens 0-5 35163433-4 2022 PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated. Reactive Oxygen Species 92-115 proline dehydrogenase 1 Homo sapiens 6-9 35163433-4 2022 PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated. Reactive Oxygen Species 117-120 proline dehydrogenase 1 Homo sapiens 0-5 35163433-4 2022 PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated. Reactive Oxygen Species 117-120 proline dehydrogenase 1 Homo sapiens 6-9 35163433-6 2022 Simultaneously, the NSAIDs inhibited collagen biosynthesis, supporting proline for PRODH/POX-induced ROS-dependent apoptosis (as demonstrated by an increase in the expression of apoptosis markers). Reactive Oxygen Species 101-104 proline dehydrogenase 1 Homo sapiens 83-88 35163433-6 2022 Simultaneously, the NSAIDs inhibited collagen biosynthesis, supporting proline for PRODH/POX-induced ROS-dependent apoptosis (as demonstrated by an increase in the expression of apoptosis markers). Reactive Oxygen Species 101-104 proline dehydrogenase 1 Homo sapiens 89-92 28990419-6 2019 CRITICAL ISSUES: Although PRODH/POX generates reactive oxygen species (ROS) for signaling, the cellular endpoint is variable and dependent on metabolic context; the switches for these responses remain unknown. Reactive Oxygen Species 46-69 proline dehydrogenase 1 Homo sapiens 26-35 28990419-6 2019 CRITICAL ISSUES: Although PRODH/POX generates reactive oxygen species (ROS) for signaling, the cellular endpoint is variable and dependent on metabolic context; the switches for these responses remain unknown. Reactive Oxygen Species 71-74 proline dehydrogenase 1 Homo sapiens 26-35