PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15322333-6 2004 Our data suggest that i) in M07e cells, SCF and exogenous H2O2 elicit a short-term activation of glucose transport through a translocation of GLUT1 from intracellular stores to plasma membranes; ii) both stimuli could share at least some signaling pathways leading to glucose uptake activation, involving protein tyrosine kinases and PLC iii) H2O2 could act increasing the level of tyrosine phosphorylation through the inhibition of tyrosine phosphatases and mimicking the regulation role of endogenous ROS. Reactive Oxygen Species 503-506 solute carrier family 2 member 1 Homo sapiens 142-147 34070830-14 2021 GLUT-1 inhibition suppressed not only the ROS levels but also the cell proliferation in KFs. Reactive Oxygen Species 42-45 solute carrier family 2 member 1 Homo sapiens 0-6 15706059-5 2004 All these data support the hypothesis that ROS can contribute to the regulation of glucose transport, not only in M07e cells but also in B1647 cells; we could speculate that one possible source of ROS, linked somehow with Glut1 activity, can be a NAD(P)H oxidase similar to that one present in phagocytic cells. Reactive Oxygen Species 43-46 solute carrier family 2 member 1 Homo sapiens 222-227 15706059-5 2004 All these data support the hypothesis that ROS can contribute to the regulation of glucose transport, not only in M07e cells but also in B1647 cells; we could speculate that one possible source of ROS, linked somehow with Glut1 activity, can be a NAD(P)H oxidase similar to that one present in phagocytic cells. Reactive Oxygen Species 197-200 solute carrier family 2 member 1 Homo sapiens 222-227 34070830-15 2021 In summary, the GLUT-1-dependent glycolysis and ROS production mediated fibroblast proliferation in keloids. Reactive Oxygen Species 48-51 solute carrier family 2 member 1 Homo sapiens 16-22 35142018-3 2022 AA-EtNBS, a 5-O-substituted ascorbate-photosensitizer (PS) conjugate, undergoes a reversible structural conversion of the ascorbate moiety in the presence of reactive oxygen species (ROS) and glutathione (GSH), thereby promoting its uptake in GLUT1-overexpressed KM12C colon cancer cells and perturbing tumor redox homeostasis, respectively. Reactive Oxygen Species 158-181 solute carrier family 2 member 1 Homo sapiens 243-248 35142018-3 2022 AA-EtNBS, a 5-O-substituted ascorbate-photosensitizer (PS) conjugate, undergoes a reversible structural conversion of the ascorbate moiety in the presence of reactive oxygen species (ROS) and glutathione (GSH), thereby promoting its uptake in GLUT1-overexpressed KM12C colon cancer cells and perturbing tumor redox homeostasis, respectively. Reactive Oxygen Species 183-186 solute carrier family 2 member 1 Homo sapiens 243-248 28427288-5 2017 Among those, Glut 1 (i.e. band 4.5), which transports glucose (insulin independent) and dehydroascorbate (DHA), was selectively chosen for its long history in reducing reactive oxygen species (ROS). Reactive Oxygen Species 168-191 solute carrier family 2 member 1 Homo sapiens 13-19 33751130-9 2021 Furthermore, we show that propofol reduces ROS overproduction, which in turn inhibits GLUT1 expression. Reactive Oxygen Species 43-46 solute carrier family 2 member 1 Homo sapiens 86-91 33532038-10 2021 Further studies demonstrated that emodin induces necroptosis through ROS-mediated activation of JNK signaling pathway and also inhibits glycolysis by downregulation of GLUT1 through ROS-mediated inactivation of the PI3K/AKT signaling pathway. Reactive Oxygen Species 182-185 solute carrier family 2 member 1 Homo sapiens 168-173 30431083-0 2019 EGFR mutation decreases FDG uptake in non-small cell lung cancer via the NOX4/ROS/GLUT1 axis. Reactive Oxygen Species 78-81 solute carrier family 2 member 1 Homo sapiens 82-87 30431083-12 2019 Reverse transcription-polymerase chain reaction indicated that the GLUT1 mRNA decreased in the PC-9 and NCI-H1975 cell lines compared with the A549 cell line (0.82+-0.07 and 0.72+-0.04 vs. 0.98+-0.04, respectively; P<0.05) and decreased ROS activity was observed in the PC-9 cell line. Reactive Oxygen Species 240-243 solute carrier family 2 member 1 Homo sapiens 67-72 28427288-5 2017 Among those, Glut 1 (i.e. band 4.5), which transports glucose (insulin independent) and dehydroascorbate (DHA), was selectively chosen for its long history in reducing reactive oxygen species (ROS). Reactive Oxygen Species 193-196 solute carrier family 2 member 1 Homo sapiens 13-19 25101238-8 2014 Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. Reactive Oxygen Species 74-77 solute carrier family 2 member 1 Homo sapiens 38-43 27465797-3 2016 Glucose transporter 1 (GLUT1) expression was assessed by western blotting and reactive oxygen species (ROS) using a fluorogenic probe. Reactive Oxygen Species 78-101 solute carrier family 2 member 1 Homo sapiens 0-21 27465797-3 2016 Glucose transporter 1 (GLUT1) expression was assessed by western blotting and reactive oxygen species (ROS) using a fluorogenic probe. Reactive Oxygen Species 78-101 solute carrier family 2 member 1 Homo sapiens 23-28 27465797-3 2016 Glucose transporter 1 (GLUT1) expression was assessed by western blotting and reactive oxygen species (ROS) using a fluorogenic probe. Reactive Oxygen Species 103-106 solute carrier family 2 member 1 Homo sapiens 0-21 27465797-3 2016 Glucose transporter 1 (GLUT1) expression was assessed by western blotting and reactive oxygen species (ROS) using a fluorogenic probe. Reactive Oxygen Species 103-106 solute carrier family 2 member 1 Homo sapiens 23-28 25101238-0 2014 Role of GLUT1 in regulation of reactive oxygen species. Reactive Oxygen Species 31-54 solute carrier family 2 member 1 Homo sapiens 8-13 25101238-2 2014 We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. Reactive Oxygen Species 99-122 solute carrier family 2 member 1 Homo sapiens 52-57 25101238-2 2014 We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. Reactive Oxygen Species 124-127 solute carrier family 2 member 1 Homo sapiens 52-57 25101238-3 2014 We found that the GLUT1 inhibitors fasentin and phloretin increased the ROS levels induced by antimycin A and the superoxide generator pyrogallol. Reactive Oxygen Species 72-75 solute carrier family 2 member 1 Homo sapiens 18-23 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 64-67 solute carrier family 2 member 1 Homo sapiens 34-39 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 64-67 solute carrier family 2 member 1 Homo sapiens 41-46 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 93-96 solute carrier family 2 member 1 Homo sapiens 34-39 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 93-96 solute carrier family 2 member 1 Homo sapiens 41-46 25101238-7 2014 In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. Reactive Oxygen Species 47-50 solute carrier family 2 member 1 Homo sapiens 27-32 25101238-7 2014 In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. Reactive Oxygen Species 117-120 solute carrier family 2 member 1 Homo sapiens 27-32 25101238-8 2014 Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. Reactive Oxygen Species 151-154 solute carrier family 2 member 1 Homo sapiens 38-43 24492615-10 2014 Finally, reactive oxygen species production and evidence of oxidative stress were significantly enhanced in GLUT1-OE MPhis; antioxidant treatment blunted the expression of inflammatory mediators such as PAI-1 (plasminogen activator inhibitor 1), suggesting that glucose-mediated oxidative stress was driving the proinflammatory response. Reactive Oxygen Species 9-32 solute carrier family 2 member 1 Homo sapiens 108-113 18473264-2 2008 In this study, by treating an acute leukaemic cell line with different antioxidants, ROS generation was shown to be crucially involved in the modulation of glucose transport (mediated by Glut1), which is frequently up-regulated in cancer cells. Reactive Oxygen Species 85-88 solute carrier family 2 member 1 Homo sapiens 187-192 21455214-6 2011 Using phloretin to inhibit Glut function, we demonstrate that glucose uptake is mandatory for ROS upregulation in IL-7-treated T-ALL cells, suggesting that IL-7 stimulation leads to increased ROS via PI3K pathway activation and consequent upregulation of Glut1 and glucose uptake. Reactive Oxygen Species 94-97 solute carrier family 2 member 1 Homo sapiens 27-31 21455214-6 2011 Using phloretin to inhibit Glut function, we demonstrate that glucose uptake is mandatory for ROS upregulation in IL-7-treated T-ALL cells, suggesting that IL-7 stimulation leads to increased ROS via PI3K pathway activation and consequent upregulation of Glut1 and glucose uptake. Reactive Oxygen Species 192-195 solute carrier family 2 member 1 Homo sapiens 27-31 19013234-1 2009 In the human acute myeloid leukemia cell line M07e, the growth factor interleukin-3 (IL-3) induces ROS formation, positively affecting Glut1-mediated glucose uptake and cell survival. Reactive Oxygen Species 99-102 solute carrier family 2 member 1 Homo sapiens 135-140 18473264-3 2008 Then, this study tried to elucidate ROS source(s) and mechanisms by which ROS are involved in Glut1 activity regulation. Reactive Oxygen Species 36-39 solute carrier family 2 member 1 Homo sapiens 94-99 18473264-3 2008 Then, this study tried to elucidate ROS source(s) and mechanisms by which ROS are involved in Glut1 activity regulation. Reactive Oxygen Species 74-77 solute carrier family 2 member 1 Homo sapiens 94-99 16356119-6 2005 In addition, prolonged exposure to ROS affects transcription of glucose transporters: whereas the level of GLUT1 is increased, GLUT4 level is reduced. Reactive Oxygen Species 35-38 solute carrier family 2 member 1 Homo sapiens 107-112 15454279-0 2004 Contribution of reactive oxygen species to the regulation of Glut1 in two hemopoietic cell lines differing in cytokine sensitivity. Reactive Oxygen Species 16-39 solute carrier family 2 member 1 Homo sapiens 61-66