PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31512776-8 2020 In Western blot assay, ROS, and apoptosis-related genes were increased in SNU-80 cells when they were cocultured with HB1.F3.CD and HB1.F3.CD.IFN-beta cells. Reactive Oxygen Species 23-26 interferon beta 1 Homo sapiens 142-150 25086905-3 2014 We show that in SH-SY5Y human neuroblastoma cells IFN-beta induced a delayed and sustained increase of p38 MAPK activity through a novel mechanism involving the sequential activation of Janus kinase-signal transducer and activator of transcription-1 signalling, enhanced expression of the NADPH oxidase catalytic subunit gp91(phox), increased reactive oxygen species production and stimulation of the MAPK kinase kinase transforming growth factor-beta-activated kinase 1. Reactive Oxygen Species 343-366 interferon beta 1 Homo sapiens 50-58 28623559-0 2017 IFN-beta-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis. Reactive Oxygen Species 17-40 interferon beta 1 Homo sapiens 0-8 28623559-4 2017 Moreover, IFN-beta induced ROS production in human myotubes was found to contribute to mitochondrial malfunctions. Reactive Oxygen Species 27-30 interferon beta 1 Homo sapiens 10-18 28623559-7 2017 Mitochondrial dysfunctions, mediated by IFN-beta induced-ROS, contribute to poor exercise capacity. Reactive Oxygen Species 57-60 interferon beta 1 Homo sapiens 40-48 27677689-10 2017 Furthermore, BTZ significantly increased the intracellular ROS generation induced by IFNbeta gene transfer in melanoma cells, an effect that was reversed by the addition of the ROS inhibitor N-acetyl-L-cystein. Reactive Oxygen Species 59-62 interferon beta 1 Homo sapiens 85-92 27677689-10 2017 Furthermore, BTZ significantly increased the intracellular ROS generation induced by IFNbeta gene transfer in melanoma cells, an effect that was reversed by the addition of the ROS inhibitor N-acetyl-L-cystein. Reactive Oxygen Species 177-180 interferon beta 1 Homo sapiens 85-92 26848042-9 2016 IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells. Reactive Oxygen Species 66-69 interferon beta 1 Homo sapiens 0-8 26848042-10 2016 Together, the results of the present study demonstrated that poly (I:C) transfection induced IFN-beta, contributing to ROS production, DNA damage, and caspase-9 and -3 activation in the HeLa cervical cancer cell line, leading to mitochondrial-mediated apoptosis. Reactive Oxygen Species 119-122 interferon beta 1 Homo sapiens 93-101 26054674-9 2015 The lower cytoplasmatic levels of reactive oxygen species detected after intracellular IFNbeta expression could be related to the resistance displayed by one human melanoma cell line. Reactive Oxygen Species 34-57 interferon beta 1 Homo sapiens 87-94 23431360-11 2013 In vitro, interferon-beta treatment decreased oxidative stress (iNOS and ROS levels) and the release of pro-inflammatory cytokines after LPS stimulation, reducing axonal damage. Reactive Oxygen Species 73-76 interferon beta 1 Homo sapiens 10-25 20532218-6 2010 Here, we found that NOX2 and ROS are required for the host cell to trigger an efficient RIG-I-mediated IRF-3 activation and downstream antiviral IFNbeta and IFIT1 gene expression. Reactive Oxygen Species 29-32 interferon beta 1 Homo sapiens 145-152 16826196-5 2007 Mitochondrial-nuclear translocation of these subunits was not observed, but overproduction of reactive oxygen species (ROS), which causes loss of mitochondrial function, was detected upon IFN-beta/RA treatment. Reactive Oxygen Species 94-117 interferon beta 1 Homo sapiens 188-196 16826196-5 2007 Mitochondrial-nuclear translocation of these subunits was not observed, but overproduction of reactive oxygen species (ROS), which causes loss of mitochondrial function, was detected upon IFN-beta/RA treatment. Reactive Oxygen Species 119-122 interferon beta 1 Homo sapiens 188-196 16826196-8 2007 Our data suggest that the MRC regulates IFN-beta/RA-induced cell death by modulating ROS production and late gene expression. Reactive Oxygen Species 85-88 interferon beta 1 Homo sapiens 40-48 22555508-8 2012 The great bystander effect of the hIFNbeta gene lipofection, involving the production of reactive oxygen species, would be among the main causes of its success. Reactive Oxygen Species 89-112 interferon beta 1 Homo sapiens 34-42 22623753-2 2012 Here, we demonstrate that signaling by IFNAR (the shared receptor for IFN-alpha and IFN-beta) on macrophages inhibits activation of Rac1 and the generation of reactive oxygen species (ROS) through suppressor of cytokine signaling 1 (SOCS1). Reactive Oxygen Species 159-182 interferon beta 1 Homo sapiens 84-92 22623753-2 2012 Here, we demonstrate that signaling by IFNAR (the shared receptor for IFN-alpha and IFN-beta) on macrophages inhibits activation of Rac1 and the generation of reactive oxygen species (ROS) through suppressor of cytokine signaling 1 (SOCS1). Reactive Oxygen Species 184-187 interferon beta 1 Homo sapiens 84-92 21170271-0 2010 Cellular reactive oxygen species inhibit MPYS induction of IFNbeta. Reactive Oxygen Species 9-32 interferon beta 1 Homo sapiens 59-66 21170271-3 2010 STING, which was recently shown to mediate activation of IFNbeta expression during infection, is a ROS sensor. Reactive Oxygen Species 99-102 interferon beta 1 Homo sapiens 57-64 21170271-4 2010 ROS induce intermolecular disulfide bonds formation in MPYS homodimer and inhibit MPYS IFNbeta stimulatory activity. Reactive Oxygen Species 0-3 interferon beta 1 Homo sapiens 87-94 21170271-6 2010 Thus, our results identify a novel mechanism for ROS regulation of IFNbeta stimulation. Reactive Oxygen Species 49-52 interferon beta 1 Homo sapiens 67-74