PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17984171-6	2008	We further demonstrate in DS NPCs that S100B is constitutively overexpressed, that overexpression leads to increased reactive oxygen species (ROS) formation and activation of stress response kinases, and that activation of this pathway results in compensatory AQP4 expression.	Reactive Oxygen Species	117-140	S100 calcium binding protein B	Homo sapiens	39-44	
17984171-6	2008	We further demonstrate in DS NPCs that S100B is constitutively overexpressed, that overexpression leads to increased reactive oxygen species (ROS) formation and activation of stress response kinases, and that activation of this pathway results in compensatory AQP4 expression.	Reactive Oxygen Species	142-145	S100 calcium binding protein B	Homo sapiens	39-44	
17984171-7	2008	In addition, AQP4 expression could be induced by direct exposure to ROS, and siRNA inhibition of AQP4 resulted in elevated levels of ROS following S100B exposure.	Reactive Oxygen Species	133-136	S100 calcium binding protein B	Homo sapiens	147-152	
17984171-8	2008	Finally, elevated levels of S100B-induced ROS and loss of AQP4 expression led to increased programmed cell death.	Reactive Oxygen Species	42-45	S100 calcium binding protein B	Homo sapiens	28-33	
30499235-4	2018	Lastly, building on recent results pointing to S100B as to a molecular determinant of myoblast-brown adipocyte transition, we propose S100B as a transducer of the deleterious effects of accumulation of reactive oxygen species in myoblasts and, potentially, myofibers concurring to the pathophysiology of sarcopenia.	Reactive Oxygen Species	202-225	S100 calcium binding protein B	Homo sapiens	134-139	
17726019-8	2007	Although both S100 proteins induced the formation of reactive oxygen species, S100B recruited phosphatidylinositol 3-kinase/AKT and NF-kappaB, whereas S100A6 activated JNK.	Reactive Oxygen Species	53-76	S100 calcium binding protein B	Homo sapiens	14-18	
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Reactive Oxygen Species	54-77	S100 calcium binding protein B	Homo sapiens	125-130	
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Reactive Oxygen Species	79-82	S100 calcium binding protein B	Homo sapiens	125-130	
12941779-4	2003	We also found that S100B-RAGE interaction triggered intracellular generation of reactive oxygen species (ROS), VSMC proliferation, and JAK2 tyrosine phosphorylation via activation of phospholipase D (PLD)2.	Reactive Oxygen Species	80-103	S100 calcium binding protein B	Homo sapiens	19-24	
12941779-4	2003	We also found that S100B-RAGE interaction triggered intracellular generation of reactive oxygen species (ROS), VSMC proliferation, and JAK2 tyrosine phosphorylation via activation of phospholipase D (PLD)2.	Reactive Oxygen Species	105-108	S100 calcium binding protein B	Homo sapiens	19-24	
26899964-2	2016	The aim of this work is to value the effect of S100b on ROS production in cells treated with Amyloid Beta Peptide and the subsequent influence on globin gene expression.	Reactive Oxygen Species	56-59	S100 calcium binding protein B	Homo sapiens	47-52	
24911518-6	2014	Nef also dramatically augmented reactive oxygen species (ROS) production and enhanced ethanol-mediated up-regulation of HCV replication so as to accelerate HCC.	Reactive Oxygen Species	32-55	S100 calcium binding protein B	Homo sapiens	0-3	
24911518-6	2014	Nef also dramatically augmented reactive oxygen species (ROS) production and enhanced ethanol-mediated up-regulation of HCV replication so as to accelerate HCC.	Reactive Oxygen Species	57-60	S100 calcium binding protein B	Homo sapiens	0-3	
23889347-14	2013	Increased Serum S100B levels in organic solvent exposure may indicate a preventive response to neuronal damage caused by reactive oxygen species (ROS) produced through oxidative metabolic pathways of organic solvents.	Reactive Oxygen Species	121-144	S100 calcium binding protein B	Homo sapiens	16-21	
23889347-14	2013	Increased Serum S100B levels in organic solvent exposure may indicate a preventive response to neuronal damage caused by reactive oxygen species (ROS) produced through oxidative metabolic pathways of organic solvents.	Reactive Oxygen Species	146-149	S100 calcium binding protein B	Homo sapiens	16-21