PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34946730-14 2021 Therefore, RF may have decreased melanin synthesis by increasing HSP70 and decreasing p53, thus decreasing MC1R/CREB/MITF and tyrosinase activity. Melanins 33-40 cAMP responsive element binding protein 1 Mus musculus 112-116 34400899-7 2021 AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2. Melanins 123-130 cAMP responsive element binding protein 1 Mus musculus 164-207 34560247-12 2021 Our findings revealed the potential mechanisms by which ermanin promoted the production of melanin through activated CREB-MITF signaling pathway and ROS function as signaling messengers are beneficial to melanin production and thereby will help develop novel therapeutic approaches for vitiligo. Melanins 91-98 cAMP responsive element binding protein 1 Mus musculus 117-121 34400899-7 2021 AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2. Melanins 123-130 cAMP responsive element binding protein 1 Mus musculus 209-213 31176710-3 2019 Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity. Melanins 232-239 cAMP responsive element binding protein 1 Mus musculus 8-47 34049220-15 2021 Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells. Melanins 164-171 cAMP responsive element binding protein 1 Mus musculus 77-81 32348553-10 2020 These results indicate that CREB and ERK regulation by galloyl-RGD contributes to reduced melanin synthesis via degradation of microphthalmia-associated transcription factor (MITF). Melanins 90-97 cAMP responsive element binding protein 1 Mus musculus 28-32 31176710-3 2019 Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity. Melanins 232-239 cAMP responsive element binding protein 1 Mus musculus 49-53 31176710-3 2019 Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity. Melanins 232-239 cAMP responsive element binding protein 1 Mus musculus 59-63 31176710-3 2019 Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity. Melanins 232-239 cAMP responsive element binding protein 1 Mus musculus 59-63 30987288-10 2019 This study demonstrates that luteolin 7-sulfate attenuates TYR gene expression through the intervention of a CREB- and MITF-mediated signaling pathway, leading to the decreased melanin synthesis. Melanins 177-184 cAMP responsive element binding protein 1 Mus musculus 109-113 30987288-0 2019 Luteolin 7-Sulfate Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression. Melanins 30-37 cAMP responsive element binding protein 1 Mus musculus 70-74 26586997-0 2015 Quercetin-3-O-beta-d-glucopyranosyl-(1 6)-beta-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells. Melanins 78-85 cAMP responsive element binding protein 1 Mus musculus 123-127 29803170-9 2018 Our data demonstrated that SQA suppressed melanin production through the cAMP/CREB- and ERK1/2-mediated downregulation of MITF in alpha-MSH-stimulated B16F10 cells and SQA has a potential therapeutic agent for the treatment of skin hyperpigmentation disorders. Melanins 42-49 cAMP responsive element binding protein 1 Mus musculus 78-82 27543340-3 2016 In this study, we focus on the melanogenesis of EMF-ELFs and find that 60-75Hz ELF-EMFs upregulate melanin synthesis by stimulated expression of tyrosinase and TRP-1 through inhibition of phosphorylation ERK, activation of CREB, and MITF up-regulation in B16F10 melanoma cells. Melanins 99-106 cAMP responsive element binding protein 1 Mus musculus 223-227 27633503-0 2016 2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway. Melanins 29-36 cAMP responsive element binding protein 1 Mus musculus 79-83 27633503-9 2016 Together, our results indicate that ETZ induces melanin synthesis via CREB phosphorylation. Melanins 48-55 cAMP responsive element binding protein 1 Mus musculus 70-74 24333333-10 2014 These data suggest that induction of MITF via the PKA/CREB pathway plays a critical role in cilostazol-induced production of melanin in B16-F10 melanoma cells. Melanins 125-132 cAMP responsive element binding protein 1 Mus musculus 54-58 26601420-0 2015 The DNA methylation inhibitor 5-azacytidine decreases melanin synthesis by inhibiting CREB phosphorylation. Melanins 54-61 cAMP responsive element binding protein 1 Mus musculus 86-90 26601420-9 2015 Therefore, we propose that 5-azacytidine may decrease melanin synthesis by downregulating MITF and tyrosinase via CREB inactivation. Melanins 54-61 cAMP responsive element binding protein 1 Mus musculus 114-118 24632067-6 2014 As a result, betulinic acid inhibited melanin production by tyrosinase, TRP-1, and TRP-2 inhibition through the regulation of CREB and MITF, which was accompanied with MEK/ERK and PI3K/Akt inactivation in IBMX-stimulated B16F10 cells. Melanins 38-45 cAMP responsive element binding protein 1 Mus musculus 126-130 21972008-6 2012 In the MITF pathway, the phosphorylation of cAMP related binding protein (CREB) activated the transcription of MITF, resulting in increasing melanin synthesis. Melanins 165-172 cAMP responsive element binding protein 1 Mus musculus 56-84 21972008-6 2012 In the MITF pathway, the phosphorylation of cAMP related binding protein (CREB) activated the transcription of MITF, resulting in increasing melanin synthesis. Melanins 165-172 cAMP responsive element binding protein 1 Mus musculus 86-90 21569106-1 2011 Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis. Melanins 265-272 cAMP responsive element binding protein 1 Mus musculus 99-138 21569106-1 2011 Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis. Melanins 265-272 cAMP responsive element binding protein 1 Mus musculus 140-144 21910056-1 2011 Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis. Melanins 233-240 cAMP responsive element binding protein 1 Mus musculus 117-156 21910056-1 2011 Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis. Melanins 233-240 cAMP responsive element binding protein 1 Mus musculus 158-162 22441938-3 2012 We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor. Melanins 167-174 cAMP responsive element binding protein 1 Mus musculus 98-102 22441938-5 2012 This is the first study to find that PDE5 inhibitor can promote melanin synthesis and reveal that PKG-dependent CREB phosphorylation and tyrosinase expression is involved in cGMP-induced melanin synthesis. Melanins 187-194 cAMP responsive element binding protein 1 Mus musculus 112-116