PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18054269-4 2008 We demonstrated that both ginkgolides (37.5microg/mL) and hypoxia (1% O(2) for 16h) can significantly increase cell viabilities and expression of phosphorylated glycogen synthase kinase (p-GSK), phosphorylated extracellular signal-regulated kinase (p-ERK), hypoxia-inducible factor-1 alpha (HIF-1alpha) and erythropoietin (EPO) in ischemic cells. Ginkgolides 26-37 erythropoietin Homo sapiens 307-321 18054269-0 2008 Ginkgolides mimic the effects of hypoxic preconditioning to protect C6 cells against ischemic injury by up-regulation of hypoxia-inducible factor-1 alpha and erythropoietin. Ginkgolides 0-11 erythropoietin Homo sapiens 158-172 18054269-4 2008 We demonstrated that both ginkgolides (37.5microg/mL) and hypoxia (1% O(2) for 16h) can significantly increase cell viabilities and expression of phosphorylated glycogen synthase kinase (p-GSK), phosphorylated extracellular signal-regulated kinase (p-ERK), hypoxia-inducible factor-1 alpha (HIF-1alpha) and erythropoietin (EPO) in ischemic cells. Ginkgolides 26-37 erythropoietin Homo sapiens 323-326 18054269-6 2008 These indicated that ginkgolides could mimic hypoxic preconditioning by increasing expression of HIF-1alpha as well as its target protein EPO and that the ginkgolides and hypoxic preconditioning role might be partly mediated by the activation of the p42/p44-mitogen-activated protein kinase and phosphatidylinositol 3"-kinase/AKT/glycogen synthase kinase 3beta pathways. Ginkgolides 21-32 erythropoietin Homo sapiens 138-141