PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21180125-7 2007 The expression of HIF-1alpha and p-ERK increased strikingly when treated with CoCl2 for 4 h. The levels of HIF-1alpha and p-ERK increased even more in the neurons pretreated with Gin for 24 h before CoCl2. Ginkgolides 179-182 mitogen-activated protein kinase 1 Homo sapiens 35-38 21180125-7 2007 The expression of HIF-1alpha and p-ERK increased strikingly when treated with CoCl2 for 4 h. The levels of HIF-1alpha and p-ERK increased even more in the neurons pretreated with Gin for 24 h before CoCl2. Ginkgolides 179-182 mitogen-activated protein kinase 1 Homo sapiens 124-127 21180125-9 2007 CONCLUSION: Gin has protective effects on neurons damaged by CoCl2 which might be related to the increase of the level of HIF-1alpha and the activation of ERK signal pathway. Ginkgolides 12-15 mitogen-activated protein kinase 1 Homo sapiens 155-158