PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10942192-9	2000	For CYP3A4 activity determinations it was concluded that in general a change in dextromethorphan/3-methoxymorphinan (DEX/3MM) ratios of 10% or more as detected with the current method, is a significant increase or decrease in the activity of CYP3A4.	3-methoxymorphinan	97-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10	
20201775-2	2010	METHODS: CYP2D6-mediated O-demethylation and CYP3A4-mediated N-demethylation of dextromethorphan (DEX) to dextrorphan (DOR) and 3-methoxymorphinan (3-MM), respectively, were utilized to assess the metabolic activities of the two enzymatic pathways.	3-methoxymorphinan	128-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51	
15988119-4	2005	Formation of 3-methoxymorphinan (3-MEM) normalized by CYP3A4/5 activity in the PM hepatocytes reached about 2.8-fold higher than that in CYP2D6 extensive metabolizer (EM) hepatocytes, which clearly showed the compensatory metabolic pathway of O-demethylation catalyzed by CYP2D6 as seen in clinical study.	3-methoxymorphinan	13-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60	
15988119-4	2005	Formation of 3-methoxymorphinan (3-MEM) normalized by CYP3A4/5 activity in the PM hepatocytes reached about 2.8-fold higher than that in CYP2D6 extensive metabolizer (EM) hepatocytes, which clearly showed the compensatory metabolic pathway of O-demethylation catalyzed by CYP2D6 as seen in clinical study.	3-methoxymorphinan	33-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60	
14689465-2	2003	Also dextromethorphan is N-demethylated in vivo to 3-methoxymorphinan by human CYP3A4/5.	3-methoxymorphinan	51-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85	
16315033-5	2005	CYP2D6 and CYP3A4 metabolic ratios were measured as the log of the ratios of the amount of DEM to the amount of dextrorphan (DOR) and of the amount of DEM to the amount of 3-methoxy-morphinan (MET) excreted in urine during a 12-h time period, respectively, following the oral administration of 80 mg of dextromethorphan hydrobromide.	3-methoxymorphinan	172-191	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-17	
16315033-5	2005	CYP2D6 and CYP3A4 metabolic ratios were measured as the log of the ratios of the amount of DEM to the amount of dextrorphan (DOR) and of the amount of DEM to the amount of 3-methoxy-morphinan (MET) excreted in urine during a 12-h time period, respectively, following the oral administration of 80 mg of dextromethorphan hydrobromide.	3-methoxymorphinan	193-196	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-17	
10942192-9	2000	For CYP3A4 activity determinations it was concluded that in general a change in dextromethorphan/3-methoxymorphinan (DEX/3MM) ratios of 10% or more as detected with the current method, is a significant increase or decrease in the activity of CYP3A4.	3-methoxymorphinan	97-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	242-248	
8043020-4	1994	B-lymphoblastoid cells expressing CYP3A4 incubated with 0.4 mM dextromethorphan catalyzed the formation of 3-methoxymorphinan at a rate of 22 pmol product/mg protein/min.	3-methoxymorphinan	107-125	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-40	
10391422-0	1999	A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers.	3-methoxymorphinan	48-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-87	
10391422-1	1999	Dextromethorphan (DM) is metabolized in the body to dextrophan (DT) and 3-methoxymorphinan (3-MM) by cytochrome P450 (CYP) 2D6 and 3A4, respectively, and cyclosporine (CsA) is a known substrate of CYP3A4.	3-methoxymorphinan	72-90	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	197-203	
9811160-11	1998	After adjustment for relative abundance, CYP3A4 was identified as the dominant enzyme mediating 3-methoxymorphinan formation from dextromethorphan, although CYP2C9 and -2C19 were estimated to contribute to 3-methoxymorphinan formation, particularly at low substrate concentrations.	3-methoxymorphinan	96-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47	
9811160-11	1998	After adjustment for relative abundance, CYP3A4 was identified as the dominant enzyme mediating 3-methoxymorphinan formation from dextromethorphan, although CYP2C9 and -2C19 were estimated to contribute to 3-methoxymorphinan formation, particularly at low substrate concentrations.	3-methoxymorphinan	206-224	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47	
8873685-2	1996	Dextromethorphan is N-demethylated in vitro to 3-methoxymorphinan by human CYP3A4/5.	3-methoxymorphinan	47-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81	
8873685-4	1996	Urinary excretion of 3-methoxymorphinan was excretion rate-limited in extensive metabolizers of CYP2D6, which necessitated a longer urine collection, 0 to 72 hours, to obtain true MR values for CYP3A.	3-methoxymorphinan	21-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	194-199	
1306804-6	1992	The N-demethylation pathway to 3-methoxymorphinan is accessory and is dependent on the CYP3A subfamily.	3-methoxymorphinan	31-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-92