PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17567463-6 2007 Nitric oxide donor (S-nitroso-N-acetylpenicillamine) inhibited Bid cleavage, the MPT, and caspase activation and reduced TNF-alpha- and Fas-mediated cell killing. S-Nitroso-N-Acetylpenicillamine 20-51 tumor necrosis factor Homo sapiens 121-130 32606304-6 2020 In addition, beta-catenin depletion abrogated the protective effects of the NO donor, S-nitroso-N-acetylpenicillamine, during TNFalpha- and H2O2-induced apoptosis. S-Nitroso-N-Acetylpenicillamine 86-117 tumor necrosis factor Homo sapiens 126-134 12919948-8 2003 Activation of PKA by SNAP or cAMP-elevating agents not only inhibited TNF-alpha-induced NF-kappaB-dependent reporter gene expression but also reduced endogenous NF-kappaB-dependent adhesion molecule and chemokine expression. S-Nitroso-N-Acetylpenicillamine 21-25 tumor necrosis factor Homo sapiens 70-79 12919948-4 2003 We found that cGMP-elevating agents such as the NO donor S-nitroso-N-acetylpenicillamine (SNAP) and C-type natriuretic peptide (CNP), reduced TNF-alpha-induced NF-kappaB-dependent reporter gene expression in rat aortic VSMCs in a cGMP-dependent manner. S-Nitroso-N-Acetylpenicillamine 57-88 tumor necrosis factor Homo sapiens 142-151 11440974-5 2001 TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P<0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P<0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P<0.05). S-Nitroso-N-Acetylpenicillamine 244-276 tumor necrosis factor Homo sapiens 0-9 11443053-4 2001 Although S-nitroso-N-acetylpenicillamine, a nitric oxide (NO) donor, also increased TNF-alpha production, NO exposure led to phosphorylation of p38 MAPK, not p42/44 MAPK. S-Nitroso-N-Acetylpenicillamine 9-40 tumor necrosis factor Homo sapiens 84-93 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. S-Nitroso-N-Acetylpenicillamine 171-202 tumor necrosis factor Homo sapiens 77-86 11673761-5 2001 RESULTS: Pretreatment of primary cultures of rat brown fat cells with micromolar concentrations of NA or the NO-donor S-nitroso-N-acetylpenicillamine (SNAP) induced the expression of HSP70 mRNA and protein, which was associated with cytoprotection against TNF-alpha plus CHX-induced apoptosis. S-Nitroso-N-Acetylpenicillamine 118-149 tumor necrosis factor Homo sapiens 256-265 11440974-5 2001 TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P<0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P<0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P<0.05). S-Nitroso-N-Acetylpenicillamine 278-282 tumor necrosis factor Homo sapiens 0-9 11118442-7 2001 Treatment of AD10 cells with the NOS inhibitor l-NMA blocked the IFN-gamma-dependent sensitization whereas NO donors (S-nitroso-N-acetylpenicillamine) sensitized these cells to TNF-alpha cytotoxicity. S-Nitroso-N-Acetylpenicillamine 118-149 tumor necrosis factor Homo sapiens 177-186 8995451-3 1997 Pretreatment of primary cultures of rat hepatocytes with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) induced the expression of heat shock protein 70 (HSP70) mRNA and protein, which was associated with thermotolerance and cytoprotection from TNFalpha+actinomycin D-induced hepatotoxicity and apoptosis. S-Nitroso-N-Acetylpenicillamine 70-101 tumor necrosis factor Homo sapiens 249-257 9738946-3 1998 We found that the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibited TNFalpha-induced endothelial apoptosis and that this was mediated partly through the cGMP pathway. S-Nitroso-N-Acetylpenicillamine 27-58 tumor necrosis factor Homo sapiens 76-84 9738946-3 1998 We found that the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibited TNFalpha-induced endothelial apoptosis and that this was mediated partly through the cGMP pathway. S-Nitroso-N-Acetylpenicillamine 60-64 tumor necrosis factor Homo sapiens 76-84 7578978-5 1995 The NO-donor S-nitroso-N-acetyl-penicillamine (SNAP,300 microM), significantly inhibited LPS and IFN-gamma induced IL-6 release, but potentiated TNF-alpha release. S-Nitroso-N-Acetylpenicillamine 13-45 tumor necrosis factor Homo sapiens 145-154 8879223-4 1996 We also report that synoviocytes, and macrophage cell lines, cultured with the NO donor, S-nitroso-acetyl penicillamine, produced high concentrations of tumor necrosis factor (TNF)-alpha. S-Nitroso-N-Acetylpenicillamine 89-119 tumor necrosis factor Homo sapiens 153-186 7578978-5 1995 The NO-donor S-nitroso-N-acetyl-penicillamine (SNAP,300 microM), significantly inhibited LPS and IFN-gamma induced IL-6 release, but potentiated TNF-alpha release. S-Nitroso-N-Acetylpenicillamine 47-51 tumor necrosis factor Homo sapiens 145-154