PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34371375-1 2021 A novel class of potential MAO-B inhibitors was designed and synthesized in good yield by combining the pyridazinone moiety with the dithiocarbamate framework, two relevant pharmacophores for drug discovery. 2-phenyl-3(2H)-pyridazinone 104-116 monoamine oxidase B Homo sapiens 27-32 34371375-2 2021 The biological results obtained for the different pyridazinone/dithiocarbamate hybrids (compounds 8-14) indicated that most of them reversibly and selectively inhibit the hMAO-B in vitro with IC50 values in the microM range and exhibit not significant cellular toxicity. 2-phenyl-3(2H)-pyridazinone 50-62 monoamine oxidase B Homo sapiens 171-177 32144745-0 2020 Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors. 2-phenyl-3(2H)-pyridazinone 63-75 monoamine oxidase B Homo sapiens 107-126