PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23200255-3	2013	N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition.	2-phenyl-3(2H)-pyridazinone	20-32	phosphodiesterase 4A	Homo sapiens	72-76	
34046629-0	2021	Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors.	2-phenyl-3(2H)-pyridazinone	0-12	phosphodiesterase 4A	Homo sapiens	103-107	
34046629-2	2021	This work describes the development and characterization of pyridazinone derivatives bearing an indole moiety as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents.	2-phenyl-3(2H)-pyridazinone	60-72	phosphodiesterase 4A	Homo sapiens	123-127	
29407945-2	2018	Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents.	2-phenyl-3(2H)-pyridazinone	52-64	phosphodiesterase 4A	Homo sapiens	90-94	
21530250-5	2011	PDE4 inhibition is strongly promoted by introduction of a hydrophobic substituent at the pyridazinone N(2) centre and a methoxy group at C-7" in the pyrazolopyridine.	2-phenyl-3(2H)-pyridazinone	89-101	phosphodiesterase 4A	Homo sapiens	0-4	
21530250-6	2011	Migration of the pyridazinone ring connection from the pyrazolopyridine 3"-centre to C-4" strongly enhances PDE4 inhibition.	2-phenyl-3(2H)-pyridazinone	17-29	phosphodiesterase 4A	Homo sapiens	108-112	
11472205-4	2001	All tested compounds were found to specifically inhibit PDE4 except for pyridazinone 3b, which showed moderate PDE4 (pIC(50) = 6.5) as well as PDE3 (pIC(50) = 6.6) inhibitory activity.	2-phenyl-3(2H)-pyridazinone	72-84	phosphodiesterase 4A	Homo sapiens	111-115	
11472205-5	2001	In both the pyridazinone and phthlazinone series it was found that N-substitution is beneficial for PDE4 inhibition, whereas in the pyridazinone series it also accounts for PDE4 selectivity.	2-phenyl-3(2H)-pyridazinone	132-144	phosphodiesterase 4A	Homo sapiens	173-177