PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25248682-1 2014 New pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs were synthesized and their inhibitory activities against DYRK1A, CDK5/p25, GSK3alpha/beta and p110-alpha isoform of PI3K evaluated using harmine as reference. 2-phenyl-3(2H)-pyridazinone 38-57 glycogen synthase kinase 3 alpha Homo sapiens 141-150