PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16481167-4	2006	Among them, tetrazole ring-containing compounds, KMI-570 (IC50=4.8 nM) and KMI-684 (IC50=1.2 nM), exhibited significantly potent BACE1 inhibitory activities.	1H-tetrazole	12-21	beta-secretase 1	Homo sapiens	129-134	
16757166-1	2006	Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced carboxylic acid groups at the P(1)(") position of KMI-420 and KMI-429, respectively, with tetrazole derivatives as carboxylic acid bioisosteres.	1H-tetrazole	210-219	beta-secretase 1	Homo sapiens	61-66