PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11836096-6 2002 The sulfonate and tetrazole functional groups have been identified as effective monoanionic biosteres of phosphate group and biphenyl ring system due to its favorable interactions with Glu115, Lys116, Lys120 residues of PTP 1B found to be more suitable aromatic functionality than naphthalene ring system for benzylic alpha,alpha-diflluoro phosphate and its biosteres. 1H-tetrazole 18-27 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 220-226 11960490-9 2002 Solution of the X-ray cocrystal structure of the ortho tetrazole analogue 29 bound to PTP1B revealed that the tetrazole moiety is well-accommodated in the active site and binds in a fashion similar to the ortho carboxylate analogue 2 reported previously. 1H-tetrazole 55-64 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 86-91 11960490-9 2002 Solution of the X-ray cocrystal structure of the ortho tetrazole analogue 29 bound to PTP1B revealed that the tetrazole moiety is well-accommodated in the active site and binds in a fashion similar to the ortho carboxylate analogue 2 reported previously. 1H-tetrazole 110-119 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 86-91 31499261-4 2019 Overall, the results of the study clearly reveal that the reported tetrazole derivatives especially NM-14 are valuable prototypes for the development of novel non-carboxylic inhibitors of PTP1B with antidiabetic potential. 1H-tetrazole 67-76 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 188-193