PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8064808-5	1994	In addition, AT2 binding for some of these compounds was increased by as much as 1000-fold over the corresponding tetrazole (e.g., AT2 IC50 17 nM for the tert-butyl sulfonylcarbamate 92).	1H-tetrazole	114-123	angiotensin II receptor, type 2	Rattus norvegicus	13-16	
8064808-5	1994	In addition, AT2 binding for some of these compounds was increased by as much as 1000-fold over the corresponding tetrazole (e.g., AT2 IC50 17 nM for the tert-butyl sulfonylcarbamate 92).	1H-tetrazole	114-123	angiotensin II receptor, type 2	Rattus norvegicus	131-134	
8277506-9	1993	Replacement of the CO2H of 9b with the bioisostere tetrazole resulted in 19 (AT1 IC50 = 15 nM) with a 2-fold loss in the AT1 and a complete loss in the AT2 binding affinity.	1H-tetrazole	51-60	angiotensin II receptor, type 2	Rattus norvegicus	152-155	
8277505-5	1993	Replacement of the terminal carboxyl (COOH) of 14a with the bioisostere tetrazole in 16 (AT1 IC50 = 5 nM, AT2 IC50 = 130 nM) not only improved the AT1 potency by 4-fold but also resulted in a 50-fold increase in AT2 activity.	1H-tetrazole	72-81	angiotensin II receptor, type 2	Rattus norvegicus	106-109	
8277505-5	1993	Replacement of the terminal carboxyl (COOH) of 14a with the bioisostere tetrazole in 16 (AT1 IC50 = 5 nM, AT2 IC50 = 130 nM) not only improved the AT1 potency by 4-fold but also resulted in a 50-fold increase in AT2 activity.	1H-tetrazole	72-81	angiotensin II receptor, type 2	Rattus norvegicus	212-215