PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32557691-13	2021	AMPK agonist AICAR was used to activate the AMPK pathway.	AICA ribonucleotide	13-18	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4	
33861582-2	2021	AMPK agonist AICAR has been reported to improve cognition.	AICA ribonucleotide	13-18	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4	
32557691-13	2021	AMPK agonist AICAR was used to activate the AMPK pathway.	AICA ribonucleotide	13-18	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	44-48	
32703218-10	2020	On the contrary, the activation of AMPK by metformin (Met) or 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) could overcome the KRAS-induced resistance to the anti-EGFR antibody in vivo and in vitro.	AICA ribonucleotide	62-107	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	35-39	
32703218-10	2020	On the contrary, the activation of AMPK by metformin (Met) or 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) could overcome the KRAS-induced resistance to the anti-EGFR antibody in vivo and in vitro.	AICA ribonucleotide	109-114	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	35-39	
32246808-5	2020	Pharmacologic activation of AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or metformin during sepsis improved the survival, while AMPK inhibition with Compound C increased mortality, impaired mitochondrial respiration, decreased OCR, and disrupted TEC metabolic fitness.	AICA ribonucleotide	38-83	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	28-32	
32246808-5	2020	Pharmacologic activation of AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or metformin during sepsis improved the survival, while AMPK inhibition with Compound C increased mortality, impaired mitochondrial respiration, decreased OCR, and disrupted TEC metabolic fitness.	AICA ribonucleotide	85-90	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	28-32	
31559637-9	2019	Furthermore, SIRT4 down-regulated 5" AMP-activated protein kinase (AMPK) signaling in Treg cells, whereas the AMPK agonist AICAR restored the expression of Foxp3 and interleukin-10 in SIRT4-overexpressing Treg cells.	AICA ribonucleotide	123-128	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	110-114	
21195169-8	2011	In addition, overexpression of wild-type phosphatase and tensin homologue deleted on chromosome 10 (PTEN) or pretreatment with aminoimidazole carboxamide ribonucleotide, an AMP-activated protein kinase (AMPK) activator, partially prevented Cd-induced ROS and activation of the mTOR pathway, as well as cell death.	AICA ribonucleotide	127-168	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	173-201	
19407487-3	2009	AICAR, one of the pharmacological AMPK activators, has been widely used to suppress cancer cell growth through activation of LKB1, an upstream kinase of AMPK.	AICA ribonucleotide	0-5	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	34-38	
19407487-3	2009	AICAR, one of the pharmacological AMPK activators, has been widely used to suppress cancer cell growth through activation of LKB1, an upstream kinase of AMPK.	AICA ribonucleotide	0-5	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	153-157	
32308539-8	2020	Furthermore, AICAR, an AMPK activator, increased CD9 expression under EF, while compound C, an AMPK inhibitor, decreased CD9 expression in keratinocytes.	AICA ribonucleotide	13-18	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	23-27	
31211863-9	2019	Attenuation or exacerbation of EtOH-induced oxidative stress by AICAR or Compound C, respectively, suggests a link between AMPK signaling, EtOH metabolism, and related oxidative stress.	AICA ribonucleotide	64-69	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	123-127	
26236947-4	2015	5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), an AMPK activator, caused growth arrest, inhibition of migration and invasion of TNBC cells.	AICA ribonucleotide	0-45	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	58-62	
26236947-4	2015	5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), an AMPK activator, caused growth arrest, inhibition of migration and invasion of TNBC cells.	AICA ribonucleotide	47-52	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	58-62