PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32278739-10 2020 The second order rate constant for reactivation of DFP-inhibited MaBChE by 2-PAM was 1.4 M-1 min-1, but was 380 fold faster for DFP-inhibited HuBChE (kr 531 M-1 min-1). Isoflurophate 51-54 peptidylglycine alpha-amidating monooxygenase Homo sapiens 77-80 32278739-12 2020 The reactivation rate of DFP-inhibited HuBChE mutant P285L by 2-PAM was reduced 5.8% (kr 92 M-1 min-1) indicating that P285 determines whether 2-PAM binds in an orientation that favors release of diisopropylphosphate. Isoflurophate 25-28 peptidylglycine alpha-amidating monooxygenase Homo sapiens 64-67 32278739-12 2020 The reactivation rate of DFP-inhibited HuBChE mutant P285L by 2-PAM was reduced 5.8% (kr 92 M-1 min-1) indicating that P285 determines whether 2-PAM binds in an orientation that favors release of diisopropylphosphate. Isoflurophate 25-28 peptidylglycine alpha-amidating monooxygenase Homo sapiens 145-148 32278739-13 2020 DFP-inhibited MaBChE treated with 0.2 M 2-PAM recovered 10% of its original activity, whereas DFP-inhibited HuBChE recovered 80% activity. Isoflurophate 0-3 peptidylglycine alpha-amidating monooxygenase Homo sapiens 42-45 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. Isoflurophate 209-212 peptidylglycine alpha-amidating monooxygenase Homo sapiens 127-130