PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11432804-6 2001 Suppression of JNK by dn-JNK1 blocked the interaction of FADD and caspase-8 and partially protected Jurkat/ras and Jurkat/Fas(m)/ras cells from apoptosis. fadd 57-61 mitogen-activated protein kinase 8 Homo sapiens 15-18 26972597-8 2016 Interestingly, FADD was also found to promote JNK1 mediated activation of E3 ubiquitin ligase ITCH to degrade cFLIPL that may lead to commencement of apoptosis. fadd 15-19 mitogen-activated protein kinase 8 Homo sapiens 46-50 15254243-8 2004 While the activation of JNK by RNS or FasL required FADD, the cysteine-rich domain 1 containing preligand assembly domain required for FasL signaling was not involved in JNK activation by RNS. fadd 52-56 mitogen-activated protein kinase 8 Homo sapiens 24-27 12417047-3 2002 We found that the overexpression of FADD sensitizes etoposide-induced apoptosis through a rapid activation of c-Jun NH(2)-terminal kinase (JNK) and, subsequently, of caspase 3. fadd 36-40 mitogen-activated protein kinase 8 Homo sapiens 110-137 12417047-3 2002 We found that the overexpression of FADD sensitizes etoposide-induced apoptosis through a rapid activation of c-Jun NH(2)-terminal kinase (JNK) and, subsequently, of caspase 3. fadd 36-40 mitogen-activated protein kinase 8 Homo sapiens 139-142 12417047-8 2002 Our results demonstrate that phosphorylated FADD-dependent activation of the JNK/caspase pathway plays a pivotal role in sensitization to etoposide-induced apoptosis in prostate cancer cells. fadd 44-48 mitogen-activated protein kinase 8 Homo sapiens 77-80 11432804-6 2001 Suppression of JNK by dn-JNK1 blocked the interaction of FADD and caspase-8 and partially protected Jurkat/ras and Jurkat/Fas(m)/ras cells from apoptosis. fadd 57-61 mitogen-activated protein kinase 8 Homo sapiens 25-29