PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1947794-2 1991 C3b is generated in situ by tryptic cleavage of C3 after co-precipitation of C3 and TT in the presence of polyethylene glycol. Polyethylene Glycols 106-125 complement C3 Homo sapiens 0-3 20594411-0 2011 Application of MS-based proteomics to study serum protein adsorption/absorption and complement C3 activation on poly(ethylene glycol) hydrogels. Polyethylene Glycols 112-133 complement C3 Homo sapiens 84-97 19271511-2 2008 The immune reaction between nanogold-labeled C3 antibody (anti-C3) and the antigen C3 took place to form the nanogold immune complex in pH 5.6 Na2 HPO4-C6H8O7 buffer solution and in the presence of polyethylene (PEG). Polyethylene Glycols 212-215 complement C3 Homo sapiens 45-47 19271511-2 2008 The immune reaction between nanogold-labeled C3 antibody (anti-C3) and the antigen C3 took place to form the nanogold immune complex in pH 5.6 Na2 HPO4-C6H8O7 buffer solution and in the presence of polyethylene (PEG). Polyethylene Glycols 212-215 complement C3 Homo sapiens 63-65 19271511-2 2008 The immune reaction between nanogold-labeled C3 antibody (anti-C3) and the antigen C3 took place to form the nanogold immune complex in pH 5.6 Na2 HPO4-C6H8O7 buffer solution and in the presence of polyethylene (PEG). Polyethylene Glycols 212-215 complement C3 Homo sapiens 63-65 29920096-4 2018 The PEGylated analogs are highly soluble and retained their inhibitory activity, with C3b binding affinity dependent on the length of the PEG chain. Polyethylene Glycols 4-7 complement C3 Homo sapiens 86-89 23360681-3 2013 The results show that, when incubated with human sera, unfunctionalized GO adsorbs a significant amount of serum proteins and strongly induces complement C3 cleavage (part of the complement activation cascade), generating C3a/C3a(des-Arg), an anaphylatoxin involved in local inflammatory responses, whereas PEGylated nano-GO (nGO-PEG) exhibits dramatic reductions in both protein binding in general and complement C3 activation. Polyethylene Glycols 307-310 complement C3 Homo sapiens 143-156 23360681-5 2013 Further mass spectrometry analysis identifies six nGO-PEG binding proteins, four of which are immune-related factors, including C3a/C3a(des-Arg). Polyethylene Glycols 54-57 complement C3 Homo sapiens 128-131 23360681-5 2013 Further mass spectrometry analysis identifies six nGO-PEG binding proteins, four of which are immune-related factors, including C3a/C3a(des-Arg). Polyethylene Glycols 54-57 complement C3 Homo sapiens 132-135 23360681-6 2013 A series of Western blot analysis demonstrate that nGO-PEG binds up to 2-fold amount of C3a/C3a(des-Arg) than unfunctionalized GO, and can efficiently decrease the level of C3a/C3a(des-Arg) in treated sera, preventing the normal interaction of C3a with its receptor. Polyethylene Glycols 55-58 complement C3 Homo sapiens 88-91 23360681-6 2013 A series of Western blot analysis demonstrate that nGO-PEG binds up to 2-fold amount of C3a/C3a(des-Arg) than unfunctionalized GO, and can efficiently decrease the level of C3a/C3a(des-Arg) in treated sera, preventing the normal interaction of C3a with its receptor. Polyethylene Glycols 55-58 complement C3 Homo sapiens 92-95 23360681-6 2013 A series of Western blot analysis demonstrate that nGO-PEG binds up to 2-fold amount of C3a/C3a(des-Arg) than unfunctionalized GO, and can efficiently decrease the level of C3a/C3a(des-Arg) in treated sera, preventing the normal interaction of C3a with its receptor. Polyethylene Glycols 55-58 complement C3 Homo sapiens 92-95 23360681-6 2013 A series of Western blot analysis demonstrate that nGO-PEG binds up to 2-fold amount of C3a/C3a(des-Arg) than unfunctionalized GO, and can efficiently decrease the level of C3a/C3a(des-Arg) in treated sera, preventing the normal interaction of C3a with its receptor. Polyethylene Glycols 55-58 complement C3 Homo sapiens 92-95 23360681-6 2013 A series of Western blot analysis demonstrate that nGO-PEG binds up to 2-fold amount of C3a/C3a(des-Arg) than unfunctionalized GO, and can efficiently decrease the level of C3a/C3a(des-Arg) in treated sera, preventing the normal interaction of C3a with its receptor. Polyethylene Glycols 55-58 complement C3 Homo sapiens 92-95 23360681-7 2013 In a proof-of-concept experiment, we demonstrate that nGO-PEG may serve to help eliminate the C3a/C3a(des-Arg) induced by other nanomaterials such as as-made GO, indicating a new strategy to modulate the immune responses evoked by one nanomaterial through the addition of another type of nanomaterial. Polyethylene Glycols 58-61 complement C3 Homo sapiens 94-97 23360681-7 2013 In a proof-of-concept experiment, we demonstrate that nGO-PEG may serve to help eliminate the C3a/C3a(des-Arg) induced by other nanomaterials such as as-made GO, indicating a new strategy to modulate the immune responses evoked by one nanomaterial through the addition of another type of nanomaterial. Polyethylene Glycols 58-61 complement C3 Homo sapiens 98-101 18486370-4 2008 Furthermore, the amounts of whole serum proteins and of opsonins such as complement C3 and immunoglobulin G adsorbed on PEG4%/PVA1% liposome were significantly smaller than those on the liposome solely modified with PEG (PEG5% liposome). Polyethylene Glycols 120-123 complement C3 Homo sapiens 73-86 1429764-1 1992 Whereas it has been commonly thought that adding polyethylene oxide PEO to a surface would diminish the capacity of the surface to cause deposition of platelets and of fibrinogen, and to activate complement C3, we present data showing exactly the opposite. Polyethylene Glycols 49-67 complement C3 Homo sapiens 196-209 7150233-1 1982 Complement component C3b has been purified from human, rabbit and bovine serum by affinity chromatography on human factor H-Sepharose after preliminary fractionation by poly(ethylene glycol) and DEAE-Sepharose. Polyethylene Glycols 169-190 complement C3 Homo sapiens 0-24 2252772-2 1990 The PEGC significantly suppressed transient leukocyte and thrombocytopenia, and release of C3a, beta-thromboglobulin and platelet factor 4, in corresponding with the quantity of grafted PEG. Polyethylene Glycols 4-7 complement C3 Homo sapiens 91-138 3721599-4 1986 The biological properties of the PEG-precipitable C3 were demonstrated by the inhibitory effect on the binding of immune complexes containing C3b to complement receptor 1. Polyethylene Glycols 33-36 complement C3 Homo sapiens 142-145 32598839-5 2020 Complement C3 opsonization in plasma was predominantly via the alternative pathway regardless of the presence of antibody, PEG, or fluorescent tag, but was higher for antibody-conjugated CLIO NWs. Polyethylene Glycols 123-126 complement C3 Homo sapiens 0-13