PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23401258-7	2013	However, under supraphysiological conditions, upon infusion with increasing amounts of the bile salt tauroursodeoxycholic acid, Abcg5 became fully rate-limiting for biliary cholesterol secretion.	Bile Acids and Salts	91-100	ATP binding cassette subfamily G member 5	Mus musculus	128-133	
21241519-9	2011	We confirmed here for the first time simvastatin increased the expression of hepatic ABCB4 and ABCG5, which involved in secretion of cholesterol and bile acids into the bile, besides upregulated ABCA1 and apoA-I.	Bile Acids and Salts	149-159	ATP binding cassette subfamily G member 5	Mus musculus	95-100	
22981383-11	2012	In addition, genes involved in cholesterol uptake (Ldlr) and bile acid excretion (Abcg5 and Abcg8) were increased in the livers of fat-1 mice.	Bile Acids and Salts	61-70	ATP binding cassette subfamily G member 5	Mus musculus	82-87	
21319191-10	2011	Study of tissue-specific Fxr knockout mice demonstrated that loss of the Fxr gene in the liver attenuated bile acid induction of hepatic Abcg5/g8 and gallbladder cholesterol content, suggesting a role of FXR in the regulation of cholesterol transport.	Bile Acids and Salts	106-115	ATP binding cassette subfamily G member 5	Mus musculus	137-142	
22665165-6	2012	The hepatic levels of mRNA encoding transporters Abcb11, Abcb4, Abca1, Abcg5, and Abcg8 were diminished in Ppara-null mice, leading to the accumulation of bile acids in the liver during the CA challenge.	Bile Acids and Salts	155-165	ATP binding cassette subfamily G member 5	Mus musculus	71-76	
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Bile Acids and Salts	117-126	ATP binding cassette subfamily G member 5	Mus musculus	14-19	
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Bile Acids and Salts	176-186	ATP binding cassette subfamily G member 5	Mus musculus	14-19	
17825296-0	2007	The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux.	Bile Acids and Salts	57-67	ATP binding cassette subfamily G member 5	Mus musculus	36-41	
32382260-6	2020	Real-time PCR and western blot results demonstrated that the expression levels of two enzymes (cholesterol 7alpha-hydroxylase (CYP7a1) and sterol 12alpha-hydroxylase (CYP8b1)) to catalyze the synthesis of bile acid from cholesterol were decreased and that two cholesterol transporters (ATP-binding cassette transporter G5/G8 (ABCG5/8)) were increased in the liver of lithogenic diet-fed mice.	Bile Acids and Salts	205-214	ATP binding cassette subfamily G member 5	Mus musculus	326-331	
16606610-5	2006	Upon EE2 treatment, estrogen receptor alpha (ERalpha) repressed the expression of bile acid and cholesterol transporters (bile salt export pump (BSEP), Na(+)/taurocholate cotransporting polypeptide (NTCP), OATP1, OATP2, ABCG5, and ABCG8) in the liver.	Bile Acids and Salts	82-91	ATP binding cassette subfamily G member 5	Mus musculus	220-225	
30611276-5	2019	Here, we found a significant increase of mRNA expression levels of phospholipid, bile salt and cholesterol/sterol transporters Abcb1b, Abcb11, Abcg1, Abcg5 and Abcg8.	Bile Acids and Salts	81-90	ATP binding cassette subfamily G member 5	Mus musculus	150-155	
28065787-15	2017	The altered bile salt pool stimulated robust secretion of cholesterol into the intestinal lumen via the sterol-exporting heterodimer adenosine triphosphate binding cassette subfamily G member 5/8 (ABCG5/G8).	Bile Acids and Salts	12-21	ATP binding cassette subfamily G member 5	Mus musculus	197-202	
29286073-6	2018	Notably, the expression of genes associated with cholesterol synthesis (sterol regulatory element-binding protein-2 and 3-hydroxy-3-methylglutaryl-CoA reductase), cholesterol secretion [ATP-binding cassette subfamily G member 5 (ABCG5) and ABCG8] and bile acid synthesis [cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), Cyp7b1, Cyp27a1 and Cyp8b1] was reduced in the livers of mice injected with BT or CF.	Bile Acids and Salts	251-260	ATP binding cassette subfamily G member 5	Mus musculus	186-227	
25582706-10	2015	Thus in conclusion, CA and DCA are more potent FXR activators than CDCA and LCA when fed to mice, and thus they are more effective in decreasing the expression of the rate limiting gene in BA synthesis Cyp7a1 and the 12-hydroxylation of BAs Cyp8b1, and are also more effective in increasing the expression of Abcg5/Abcg8, which is responsible for biliary cholesterol excretion.	Bile Acids and Salts	189-191	ATP binding cassette subfamily G member 5	Mus musculus	309-314