PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11062150-6 2000 Transcripts of the neutral, bile salt-independent retinyl ester hydrolase and the bile salt-dependent retinyl ester hydrolase were undetectable in all of the normal cell types, including the epithelial cells. Bile Acids and Salts 28-37 carboxylesterase 1 Homo sapiens 50-73 11062150-6 2000 Transcripts of the neutral, bile salt-independent retinyl ester hydrolase and the bile salt-dependent retinyl ester hydrolase were undetectable in all of the normal cell types, including the epithelial cells. Bile Acids and Salts 82-91 carboxylesterase 1 Homo sapiens 102-125 1627617-0 1992 Characterization of a bile salt-dependent cholesteryl ester hydrolase activity secreted from HepG2 cells. Bile Acids and Salts 22-31 carboxylesterase 1 Homo sapiens 42-69 7756263-0 1995 Role of bile salt-dependent cholesteryl ester hydrolase in the uptake of micellar cholesterol by intestinal cells. Bile Acids and Salts 8-17 carboxylesterase 1 Homo sapiens 28-55 9500571-5 1998 Similar results were obtained in cells in which ACAT activity was induced by preincubation either with 25-hydroxycholesterol and mevalonic acid or with CEase and bile salt mixed-micelles containing 100 micromol/L cholesterol. Bile Acids and Salts 162-171 carboxylesterase 1 Homo sapiens 48-52 8381481-2 1993 Apocellular retinol-binding protein (CRBP) stimulates a bile-salt independent membrane-bound retinyl ester hydrolase resulting in the hydrolysis of endogenous retinyl esters and the formation of holoCRBP. Bile Acids and Salts 56-65 carboxylesterase 1 Homo sapiens 93-116 1627617-2 1992 Although bile salt-dependent CEH activity was measured in the medium at 6 to 96 h (up to 4500 pmol/h per mg cell protein), there was very little activity detected in the corresponding cell homogenates (less than 70 pmol/h per mg cell protein). Bile Acids and Salts 9-18 carboxylesterase 1 Homo sapiens 29-32 1627617-4 1992 Incubation of HepG2 cells with brefeldin A resulted in an 80 to 90% inhibition of secretion of the bile salt-dependent CEH activity, while only inhibiting total protein secretion by 42%. Bile Acids and Salts 99-108 carboxylesterase 1 Homo sapiens 119-122 34153284-3 2021 It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts. Bile Acids and Salts 395-405 carboxylesterase 1 Homo sapiens 32-36 30169917-7 2018 In silico analysis suggested that bile acid inhibition of CES1 involved both binding to the active and superficial sites of the enzyme. Bile Acids and Salts 34-43 carboxylesterase 1 Homo sapiens 58-62 23990661-8 2013 CEH and SR-BI expression enhanced the movement of [3H]label from HDL-[3H]CE to bile acids in vitro and in vivo. Bile Acids and Salts 79-89 carboxylesterase 1 Homo sapiens 0-3 28349866-5 2017 Furthermore, the upregulated CEH expression in the hepatocytes significantly enhanced the intracellular hydrolysis of high density lipoprotein-associated CE (HDL-CE) and subsequent conversion/secretion of hydrolyzed FC as bile acids (BA). Bile Acids and Salts 222-232 carboxylesterase 1 Homo sapiens 29-32 28349866-5 2017 Furthermore, the upregulated CEH expression in the hepatocytes significantly enhanced the intracellular hydrolysis of high density lipoprotein-associated CE (HDL-CE) and subsequent conversion/secretion of hydrolyzed FC as bile acids (BA). Bile Acids and Salts 234-236 carboxylesterase 1 Homo sapiens 29-32 24563511-4 2014 We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression. Bile Acids and Salts 119-128 carboxylesterase 1 Homo sapiens 47-59 24563511-4 2014 We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression. Bile Acids and Salts 119-128 carboxylesterase 1 Homo sapiens 61-64 24563511-4 2014 We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression. Bile Acids and Salts 119-128 carboxylesterase 1 Homo sapiens 66-70 23744992-3 2013 Earlier, we demonstrated that overexpression of human CE hydrolase (Gene symbol CES1) increased bile acid synthesis in human hepatocytes and enhanced reverse cholesterol transport in mice. Bile Acids and Salts 96-105 carboxylesterase 1 Homo sapiens 80-84 16962139-4 2006 Here we present four crystal structures of the hCE1 glycoprotein in complexes with the following endogenous substrates or substrate analogues: Coenzyme A, the fatty acid palmitate, and the bile acids cholate and taurocholate. Bile Acids and Salts 189-199 carboxylesterase 1 Homo sapiens 47-51