PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30169917-7	2018	In silico analysis suggested that bile acid inhibition of CES1 involved both binding to the active and superficial sites of the enzyme.	Bile Acids and Salts	34-43	carboxylesterase 1	Homo sapiens	58-62	
28349866-5	2017	Furthermore, the upregulated CEH expression in the hepatocytes significantly enhanced the intracellular hydrolysis of high density lipoprotein-associated CE (HDL-CE) and subsequent conversion/secretion of hydrolyzed FC as bile acids (BA).	Bile Acids and Salts	222-232	carboxylesterase 1	Homo sapiens	29-32	
28349866-5	2017	Furthermore, the upregulated CEH expression in the hepatocytes significantly enhanced the intracellular hydrolysis of high density lipoprotein-associated CE (HDL-CE) and subsequent conversion/secretion of hydrolyzed FC as bile acids (BA).	Bile Acids and Salts	234-236	carboxylesterase 1	Homo sapiens	29-32	
24563511-4	2014	We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression.	Bile Acids and Salts	119-128	carboxylesterase 1	Homo sapiens	47-59	
24563511-4	2014	We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression.	Bile Acids and Salts	119-128	carboxylesterase 1	Homo sapiens	61-64	
24563511-4	2014	We have earlier demonstrated the role of human CE hydrolase (CEH, CES1) in hepatic hydrolysis of HDL-CE and increasing bile acid synthesis, a process dependent on scavenger receptor BI expression.	Bile Acids and Salts	119-128	carboxylesterase 1	Homo sapiens	66-70	
23990661-8	2013	CEH and SR-BI expression enhanced the movement of [3H]label from HDL-[3H]CE to bile acids in vitro and in vivo.	Bile Acids and Salts	79-89	carboxylesterase 1	Homo sapiens	0-3	
16962139-4	2006	Here we present four crystal structures of the hCE1 glycoprotein in complexes with the following endogenous substrates or substrate analogues: Coenzyme A, the fatty acid palmitate, and the bile acids cholate and taurocholate.	Bile Acids and Salts	189-199	carboxylesterase 1	Homo sapiens	47-51	
23744992-3	2013	Earlier, we demonstrated that overexpression of human CE hydrolase (Gene symbol CES1) increased bile acid synthesis in human hepatocytes and enhanced reverse cholesterol transport in mice.	Bile Acids and Salts	96-105	carboxylesterase 1	Homo sapiens	80-84	
9500571-5	1998	Similar results were obtained in cells in which ACAT activity was induced by preincubation either with 25-hydroxycholesterol and mevalonic acid or with CEase and bile salt mixed-micelles containing 100 micromol/L cholesterol.	Bile Acids and Salts	162-171	carboxylesterase 1	Homo sapiens	48-52	
11062150-6	2000	Transcripts of the neutral, bile salt-independent retinyl ester hydrolase and the bile salt-dependent retinyl ester hydrolase were undetectable in all of the normal cell types, including the epithelial cells.	Bile Acids and Salts	28-37	carboxylesterase 1	Homo sapiens	50-73	
11062150-6	2000	Transcripts of the neutral, bile salt-independent retinyl ester hydrolase and the bile salt-dependent retinyl ester hydrolase were undetectable in all of the normal cell types, including the epithelial cells.	Bile Acids and Salts	82-91	carboxylesterase 1	Homo sapiens	102-125	
1627617-2	1992	Although bile salt-dependent CEH activity was measured in the medium at 6 to 96 h (up to 4500 pmol/h per mg cell protein), there was very little activity detected in the corresponding cell homogenates (less than 70 pmol/h per mg cell protein).	Bile Acids and Salts	9-18	carboxylesterase 1	Homo sapiens	29-32	
7756263-0	1995	Role of bile salt-dependent cholesteryl ester hydrolase in the uptake of micellar cholesterol by intestinal cells.	Bile Acids and Salts	8-17	carboxylesterase 1	Homo sapiens	28-55	
8381481-2	1993	Apocellular retinol-binding protein (CRBP) stimulates a bile-salt independent membrane-bound retinyl ester hydrolase resulting in the hydrolysis of endogenous retinyl esters and the formation of holoCRBP.	Bile Acids and Salts	56-65	carboxylesterase 1	Homo sapiens	93-116	
1627617-0	1992	Characterization of a bile salt-dependent cholesteryl ester hydrolase activity secreted from HepG2 cells.	Bile Acids and Salts	22-31	carboxylesterase 1	Homo sapiens	42-69	
1627617-4	1992	Incubation of HepG2 cells with brefeldin A resulted in an 80 to 90% inhibition of secretion of the bile salt-dependent CEH activity, while only inhibiting total protein secretion by 42%.	Bile Acids and Salts	99-108	carboxylesterase 1	Homo sapiens	119-122	
34153284-3	2021	It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts.	Bile Acids and Salts	395-405	carboxylesterase 1	Homo sapiens	32-36