PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18656623-1 2008 BACKGROUND: Bile acid (BA) reclamation following ileo-cecal resection (ICR) may prevent colonic mucosa from chronic injury. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 12-21 34365653-5 2022 Antibiotics induced an enlarged bile acid (BA) pool, and dysregulated BA profiles contributed to enhanced RA signaling in mucosal DCs. Bile Acids and Salts 43-45 glucosidase beta 2 Mus musculus 32-41 17257589-2 2007 Here, by conjugating a nitrogenated base (NB) to the side chain of a bile acid (BA) moiety, we have synthesized and evaluated six novel compounds, designated BANB-1 to -6, with potential cytostatic activity and vectoriality toward enterohepatic tumors. Bile Acids and Salts 80-82 glucosidase beta 2 Mus musculus 69-78 17080196-2 2006 To gain insight into the biological function of this enzyme and its substrates, we generated mice deficient in GBA2 and found that these animals had normal bile acid metabolism. Bile Acids and Salts 156-165 glucosidase beta 2 Mus musculus 111-115 17080191-5 2006 Surprisingly, GBA2 deficiency leaves bile acid and cholesterol metabolism intact, instead causing lipid accumulation in the ER of testicular Sertoli cells, round-headed sperm (globozoospermia), and impaired male fertility. Bile Acids and Salts 37-46 glucosidase beta 2 Mus musculus 14-18 17080196-1 2006 beta-Glucosidase 2 (GBA2) is a resident enzyme of the endoplasmic reticulum thought to play a role in the metabolism of bile acid-glucose conjugates. Bile Acids and Salts 120-129 glucosidase beta 2 Mus musculus 0-18 17080196-1 2006 beta-Glucosidase 2 (GBA2) is a resident enzyme of the endoplasmic reticulum thought to play a role in the metabolism of bile acid-glucose conjugates. Bile Acids and Salts 120-129 glucosidase beta 2 Mus musculus 20-24 33811694-2 2021 Bile acid (BA) homeostasis alterations are associated with obesity. Bile Acids and Salts 11-13 glucosidase beta 2 Mus musculus 0-9 34896286-3 2022 Bile acid (BA) signaling was shown to participate in progression of AALD. Bile Acids and Salts 11-13 glucosidase beta 2 Mus musculus 0-9 34945009-1 2021 Bile acids exert diverse actions on host metabolism and immunity through bile acid-activated receptors, including Takeda G protein-coupled receptor 5 (TGR5). Bile Acids and Salts 0-10 glucosidase beta 2 Mus musculus 73-82 34382807-0 2021 Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy. Bile Acids and Salts 58-67 glucosidase beta 2 Mus musculus 19-28 34624320-1 2021 AIMS: The bile acid (BA), tauroursodeoxycholic acid (TUDCA) regulates glucose homeostasis; however, it is not clear whether its effects on insulin signaling are due to its direct interaction with the insulin receptor (IR) or through activation of the G-coupled BA receptor, TGR5. Bile Acids and Salts 21-23 glucosidase beta 2 Mus musculus 10-19 34642435-3 2021 Among liver metabolites, bile acid (BA) is a key signaling molecule that regulates liver regeneration. Bile Acids and Salts 36-38 glucosidase beta 2 Mus musculus 25-34 35381309-6 2022 Genes associated with bile acid (BA) metabolism and transport, including sodium taurocholate cotransporting polypeptide (NTCP), cytochrome P450 8B1 (CYP8B1), bile-salt export pump (BSEP), multidrug resistance P-glycoproteins 1 (MDR1), and farnesoid X receptor (FXR), were measured at the transcript and protein levels to investigate the potential mechanisms through which cholestasis is aroused by EF. Bile Acids and Salts 33-35 glucosidase beta 2 Mus musculus 22-31 34357336-10 2021 The expression of the bile acid synthesis enzymes cytochrome P450 (CYP) 7A1 and aldo-keto reductase (AKR) 1D1 tended to decrease or were decreased in mice with AE, along with decreased expression of the bile acid transporters Na+/taurocholate cotransporting polypeptide (NTCP) and bile salt efflux pump (BSEP). Bile Acids and Salts 281-290 glucosidase beta 2 Mus musculus 22-31 35351576-3 2022 Our previous studies found that the water extract of Radix scutellariae (WESB) could exert hypoglycemic and hypolipidemic efficacies by adjusting the ileum FXR-medicated interaction between gut microbiota and bile acid (BA) metabolism. Bile Acids and Salts 220-222 glucosidase beta 2 Mus musculus 209-218 35433798-1 2022 Changes in overall bile acid (BA) levels and specific BA metabolites are involved in metabolic diseases, gastrointestinal, and liver cancer. Bile Acids and Salts 30-32 glucosidase beta 2 Mus musculus 19-28 35065044-1 2022 Emerging evidence points to a strong association between the bile acid (BA)-gut microbiota (GM) axis, and the risk of colorectal cancer (CRC). Bile Acids and Salts 72-74 glucosidase beta 2 Mus musculus 61-70 35292350-4 2022 RESULTS: We show that SIRT5 is downregulated in human primary HCC samples, and Sirt5 deficiency in mice synergizes with oncogenes to increase bile acid (BA) production, which is due to hypersuccinylation and increased BA biosynthesis in the peroxisome of hepatocytes. Bile Acids and Salts 153-155 glucosidase beta 2 Mus musculus 142-151 35292350-4 2022 RESULTS: We show that SIRT5 is downregulated in human primary HCC samples, and Sirt5 deficiency in mice synergizes with oncogenes to increase bile acid (BA) production, which is due to hypersuccinylation and increased BA biosynthesis in the peroxisome of hepatocytes. Bile Acids and Salts 218-220 glucosidase beta 2 Mus musculus 142-151 35018684-6 2022 Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1beta expression in brown adipose tissue (p < .05). Bile Acids and Salts 108-110 glucosidase beta 2 Mus musculus 17-26 34984925-1 2022 Mice exposed in gestation to maternal high fat/high sucrose (HF/HS) diet develop altered bile acid (BA) homeostasis. Bile Acids and Salts 100-102 glucosidase beta 2 Mus musculus 89-98 35257010-7 2022 Furthermore, CGA was shown to inhibit the enterohepatic farnesoid X receptor (FXR) fibroblast growth factor 15 (FGF15) pathway and changes serum bile acid (BA) pool, thereby contributing to the increased expression of cholesterol 7 alpha-hydroxylase (CYP7A1). Bile Acids and Salts 156-158 glucosidase beta 2 Mus musculus 145-154 35018684-6 2022 Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1beta expression in brown adipose tissue (p < .05). Bile Acids and Salts 28-30 glucosidase beta 2 Mus musculus 17-26 33522359-3 2021 Studies suggest a role of Nrf2 in regulating bile acid (BA) metabolism in male mice. Bile Acids and Salts 56-58 glucosidase beta 2 Mus musculus 45-54 33604531-1 2021 Background & Aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload. Bile Acids and Salts 56-58 glucosidase beta 2 Mus musculus 45-54 33783040-2 2021 Bile acid (BA) is closely related to lipid metabolism and gut microbiota, and essential for gut homeostasis. Bile Acids and Salts 11-13 glucosidase beta 2 Mus musculus 0-9 33461458-1 2021 BACKGROUND: The role of multidrug resistance-associated protein 3 (Mrp3) in the transport of bile acid (BA) in drug-induced cholestasis have not been well studied. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 93-102 33604531-1 2021 Background & Aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload. Bile Acids and Salts 143-145 glucosidase beta 2 Mus musculus 45-54 32771984-1 2020 INTRODUCTION: Bile acid (BA) biotransformation by gut bacteria impacts BA profile and signaling to nuclear receptors, such as the farnesoid X receptor (FXR) regulating glucose metabolism. Bile Acids and Salts 25-27 glucosidase beta 2 Mus musculus 14-23 32738332-1 2020 The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in bile acid (BA) homeostasis remains controversial. Bile Acids and Salts 77-79 glucosidase beta 2 Mus musculus 66-75 32404932-3 2020 Intestinal FXR is critical in suppressing hepatic bile acid (BA) synthesis by inducing fibroblast growth factor 15 (FGF15) in mice and FGF19 in humans. Bile Acids and Salts 61-63 glucosidase beta 2 Mus musculus 50-59 32703425-3 2020 HF can elevate the intestinal and circulating bile acid (BA) levels, especially deoxycholic acid (DCA). Bile Acids and Salts 57-59 glucosidase beta 2 Mus musculus 46-55 32437836-3 2020 Bile acid (BA) pools in the enterohepatic circulation could be valuable for probing complex biochemical interactions between host and their symbiotic microbiota. Bile Acids and Salts 11-13 glucosidase beta 2 Mus musculus 0-9 32771984-1 2020 INTRODUCTION: Bile acid (BA) biotransformation by gut bacteria impacts BA profile and signaling to nuclear receptors, such as the farnesoid X receptor (FXR) regulating glucose metabolism. Bile Acids and Salts 71-73 glucosidase beta 2 Mus musculus 14-23 31195146-3 2019 The role of PPARalpha in bile acid (BA) homeostasis is beginning to emerge. Bile Acids and Salts 36-38 glucosidase beta 2 Mus musculus 25-34 32408110-1 2020 BACKGROUND: The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 35-44 32075905-7 2020 Bile acid sequestrants (BAS) are orally administered polymers that bind bile acids in the intestine forming nonabsorbable complexes. Bile Acids and Salts 72-82 glucosidase beta 2 Mus musculus 0-9 32103176-6 2020 This included the amino acid conjugations of host bile acids that were used to produce phenylalanocholic acid, tyrosocholic acid and leucocholic acid, which have not previously been characterized despite extensive research on bile-acid chemistry14. Bile Acids and Salts 50-60 glucosidase beta 2 Mus musculus 226-235 31645370-1 2020 The bile acid (BA) composition in mice is substantially different from that in humans. Bile Acids and Salts 15-17 glucosidase beta 2 Mus musculus 4-13 32034442-1 2020 AIMS/HYPOTHESIS: Bile-acid (BA) signalling is crucial in metabolism homeostasis and has recently been found to mediate the therapeutic effects of glucose-lowering treatments, including alpha-glucosidase inhibitor (AGI). Bile Acids and Salts 28-30 glucosidase beta 2 Mus musculus 17-26 32268085-3 2020 TDG loss leads to a prediabetic state, as well as bile acid (BA) accumulation in the liver and serum of male mice. Bile Acids and Salts 61-63 glucosidase beta 2 Mus musculus 50-59 32225042-4 2020 Here, LC/MS-based untargeted metabolomics was applied to investigate the differences in the metabolome, specifically in the bile acid (BA) profile of wild-type (WT) and MR1-/- KO mice, as well as how antibiotics change these profiles. Bile Acids and Salts 135-137 glucosidase beta 2 Mus musculus 124-133 31129431-5 2019 The serum and liver bile acid (BA) levels were detected by ultra performance liquid chromatography-tandem mass spectrometry. Bile Acids and Salts 31-33 glucosidase beta 2 Mus musculus 20-29 31004524-1 2019 The mechanisms by which alterations in intestinal bile acid (BA) metabolism improve systemic glucose tolerance and hepatic metabolic homeostasis are incompletely understood. Bile Acids and Salts 61-63 glucosidase beta 2 Mus musculus 50-59 31213388-2 2019 OBJECTIVE: To investigate the effect of diet and the bile acid (BA) receptors, such as TGR5 (Takeda G protein receptor 5) and S1PR2 (sphingosine-1-phosphate receptor 2) in the development of dermatitis. Bile Acids and Salts 64-66 glucosidase beta 2 Mus musculus 53-62 26372644-2 2015 We recently reported that short-term CR increased the bile acid (BA) pool size in mice, likely due to increased BA synthesis in liver. Bile Acids and Salts 65-67 glucosidase beta 2 Mus musculus 54-63 31366871-2 2019 Cholestasis is a DILI that results from impairment of bile acid transporters, such as the bile salt export pump (BSEP), leading to accumulation of bile acids. Bile Acids and Salts 147-157 glucosidase beta 2 Mus musculus 54-63 29498526-5 2018 The serum metabolome of wild-type mice segregated from that of the Ppara-null mice, driven by changes of bile acid (BA) metabolites. Bile Acids and Salts 116-118 glucosidase beta 2 Mus musculus 105-114 29175670-1 2018 Apolipoprotein E (ApoE) plays a central role in lipid transport and cholesterol metabolism, with surplus cholesterol being removed from the liver through bile acid (BA) synthesis. Bile Acids and Salts 165-167 glucosidase beta 2 Mus musculus 154-163 29058872-5 2017 We found that the most abundant bile acid in the mouse (beta-muricholic acid) binds with weak affinity individually and in combination with other bile acids. Bile Acids and Salts 146-156 glucosidase beta 2 Mus musculus 32-41 28892150-1 2017 Dysregulated bile acid (BA) synthesis or reduced farnesoid X receptor (FXR) levels are found in patients having metabolic diseases, autoimmune hepatitis, and liver cirrhosis or cancer. Bile Acids and Salts 24-26 glucosidase beta 2 Mus musculus 13-22 27580383-1 2016 BACKGROUND: Fibroblast growth factor (FGF) 15/19 is part of the gut-liver crosstalk accounting for bile acid (BA) metabolism regulation. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 99-108 29944388-2 2018 Klb-/- mice are refractory to metabolic FGF15 and FGF21 action and exhibit derepressed (increased) bile acid (BA) synthesis. Bile Acids and Salts 110-112 glucosidase beta 2 Mus musculus 99-108 29382564-1 2018 Impaired regulation of bile acid (BA) homeostasis has been suggested to be associated with adverse metabolic consequences. Bile Acids and Salts 34-36 glucosidase beta 2 Mus musculus 23-32 29930976-9 2018 Bile acids also activated Nrf2 in Drosophila enterocytes and enterocyte-specific knockdown of Nrf2 increased sensitivity of flies to bile acid-induced toxicity. Bile Acids and Salts 0-10 glucosidase beta 2 Mus musculus 133-142 28249287-3 2017 Recent studies suggest that the inflammatory response may play an important role in bile acid-induced liver injury, as pro-inflammatory cytokine expression is stimulated by bile acids in mouse hepatocyte cultures. Bile Acids and Salts 173-183 glucosidase beta 2 Mus musculus 84-93 27111442-1 2016 Bile acid (BA) sequestrants, lipid-lowering agents, may be prescribed as a monotherapy or combination therapy to reduce the risk of coronary artery disease. Bile Acids and Salts 11-13 glucosidase beta 2 Mus musculus 0-9 26372644-2 2015 We recently reported that short-term CR increased the bile acid (BA) pool size in mice, likely due to increased BA synthesis in liver. Bile Acids and Salts 112-114 glucosidase beta 2 Mus musculus 54-63 25346535-8 2015 Consistent with disturbed hepatic clock gene expression in MLL4 mutant mice, we found that rhythmic fluctuation of hepatic and serum bile acid (BA) levels over the circadian cycle is abolished in MLL4 mutant mice. Bile Acids and Salts 144-146 glucosidase beta 2 Mus musculus 133-142 24378326-3 2014 We hypothesized that this infection would also modulate hepatic drug transporter expression and key genes of bile acid (BA) synthesis and transport. Bile Acids and Salts 120-122 glucosidase beta 2 Mus musculus 109-118 24118394-1 2014 OBJECTIVE: Bile acid (BA) synthesis is regulated by negative feedback end-product inhibition, initiated by farnesoid X receptors (FXRs) in liver and gut. Bile Acids and Salts 22-24 glucosidase beta 2 Mus musculus 11-20 24120911-1 2014 BACKGROUND & AIMS: Retinoid X Receptor alpha (RXRalpha) is the principal heterodimerization partner of class II Nuclear Receptors (NRs), and a major regulator of gene expression of numerous hepatic processes, including bile acid (BA) homeostasis through multiple partners. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 223-232 21747115-0 2011 Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Bile Acids and Salts 22-32 glucosidase beta 2 Mus musculus 52-61 21346810-1 2011 BACKGROUND: Diurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system of mammals has been known for a long time. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 35-44 22542490-1 2012 BACKGROUND & AIMS: Blocking intestinal bile acid (BA) absorption by inhibiting or inactivating the apical sodium-dependent BA transporter (Asbt) classically induces hepatic BA synthesis. Bile Acids and Salts 0-2 glucosidase beta 2 Mus musculus 43-52 22542490-1 2012 BACKGROUND & AIMS: Blocking intestinal bile acid (BA) absorption by inhibiting or inactivating the apical sodium-dependent BA transporter (Asbt) classically induces hepatic BA synthesis. Bile Acids and Salts 54-56 glucosidase beta 2 Mus musculus 43-52