PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25804128-2	2015	The ATP-binding cassette transporters G5 and G8 (ABCG5 and ABCG8) play an important role in intestinal sterol absorption and bile acid secretion.	Bile Acids and Salts	125-134	ATP binding cassette subfamily G member 5	Homo sapiens	4-47	
31169656-11	2019	In PS, activation of bile acid transport by ACBC11 interconnects with hepatic upregulation of ABCG5/G8 enriching PS with bile acids and plant sterols.	Bile Acids and Salts	21-30	ATP binding cassette subfamily G member 5	Homo sapiens	94-99	
31169656-11	2019	In PS, activation of bile acid transport by ACBC11 interconnects with hepatic upregulation of ABCG5/G8 enriching PS with bile acids and plant sterols.	Bile Acids and Salts	121-131	ATP binding cassette subfamily G member 5	Homo sapiens	94-99	
29420298-4	2018	Model simulations perfectly recapitulate the measured dependence of bile salt-dependent biliary lipid extraction rates upon modulation of the membrane cholesterol (lack or overexpression of the cholesterol transporter Abcg5-Abcg8) and phosphatidylcholine (lack of Mdr2, also known as Abcb4) content.	Bile Acids and Salts	68-77	ATP binding cassette subfamily G member 5	Homo sapiens	218-223	
33141631-4	2021	Biochemical and structural information on ABC sterol transporters is beginning to emerge, with published structures of ABCA1 and ABCG5/G8; these two proteins function in the reverse cholesterol transport pathway and mediate the efflux of cholesterol and xenosterols to high-density lipoprotein and bile-salt micelles, respectively.	Bile Acids and Salts	298-307	ATP binding cassette subfamily G member 5	Homo sapiens	129-134	
30930437-5	2019	The ATP-binding cassette (ABC) transporter family members, ABCB11, ABCB4 and ABCG5/ABCG8, mediate the biliary secretion of bile salts, phospholipids and cholesterol, respectively.	Bile Acids and Salts	123-133	ATP binding cassette subfamily G member 5	Homo sapiens	77-82	
25804128-2	2015	The ATP-binding cassette transporters G5 and G8 (ABCG5 and ABCG8) play an important role in intestinal sterol absorption and bile acid secretion.	Bile Acids and Salts	125-134	ATP binding cassette subfamily G member 5	Homo sapiens	49-54	
20210363-11	2010	Bile acids may promote an active conformation of purified ABCG5/G8 either by global stabilization of the transporter or by binding to a specific site on ABCG5/G8.	Bile Acids and Salts	0-10	ATP binding cassette subfamily G member 5	Homo sapiens	58-63	
20210363-11	2010	Bile acids may promote an active conformation of purified ABCG5/G8 either by global stabilization of the transporter or by binding to a specific site on ABCG5/G8.	Bile Acids and Salts	0-10	ATP binding cassette subfamily G member 5	Homo sapiens	153-158	
17690481-7	2007	Finally, in HEK293 cells stably expressing ABCG5/G8, bile acid micelle-mediated sterol efflux was significantly accelerated.	Bile Acids and Salts	53-62	ATP binding cassette subfamily G member 5	Homo sapiens	43-48	
15121760-6	2004	Finally, deoxycholic acid repressed the ABCG5 and ABCG8 promoters, consistent with bile acid regulation via the farnesoid X receptor-small heterodimeric partner-LRH-1 pathway.	Bile Acids and Salts	83-92	ATP binding cassette subfamily G member 5	Homo sapiens	40-45	
21353662-5	2011	Expression of bile salt and phospholipid transport proteins is regulated bij the bile salt nuclear receptor Farnesoid X receptor (FXR), while the Liver X Receptor (LXR) alpha regulates ABCG5-G8.	Bile Acids and Salts	14-23	ATP binding cassette subfamily G member 5	Homo sapiens	185-190	
21319191-8	2011	Treatment of mouse or human hepatocytes with a farnesoid X receptor (FXR) agonist GW4064 or bile acids induced hepatic Abcg5/g8 expression.	Bile Acids and Salts	92-102	ATP binding cassette subfamily G member 5	Homo sapiens	119-124	
20210363-0	2010	Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8.	Bile Acids and Salts	0-10	ATP binding cassette subfamily G member 5	Homo sapiens	76-81	
20210363-2	2010	Previous studies demonstrated that bile acids increased ABCG5/G8 specific cholesterol efflux in cell models.	Bile Acids and Salts	35-45	ATP binding cassette subfamily G member 5	Homo sapiens	56-61	
20210363-3	2010	In this study we tested the effects of bile acids on ATP hydrolysis in Pichia pastoris purified ABCG5/G8 and found that they stimulated hydrolysis approximately 20-fold in wild-type ABCG5/G8 but not in a hydrolysis-deficient mutant.	Bile Acids and Salts	39-49	ATP binding cassette subfamily G member 5	Homo sapiens	96-101	
20210363-3	2010	In this study we tested the effects of bile acids on ATP hydrolysis in Pichia pastoris purified ABCG5/G8 and found that they stimulated hydrolysis approximately 20-fold in wild-type ABCG5/G8 but not in a hydrolysis-deficient mutant.	Bile Acids and Salts	39-49	ATP binding cassette subfamily G member 5	Homo sapiens	182-187	
20210363-10	2010	The data demonstrate that bile acids together with lipids and cholesterol increase ATP hydrolysis in purified ABCG5/G8.	Bile Acids and Salts	26-36	ATP binding cassette subfamily G member 5	Homo sapiens	110-115