PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21193454-2 2011 We previously reported that bile acids activate the Cdx2 promoter via nuclear factor kappa B (NF-kappaB) and stimulate production of Cdx2 protein in oesophageal keratinocytes, resulting in production of intestinal-type mucin. Bile Acids and Salts 28-38 LOC100508689 Homo sapiens 219-224 27347902-7 2016 Mucin secretion in the gallbladder is stimulated predominantly by calcium-dependent pathways that are activated by ATP present in bile, and bile acids. Bile Acids and Salts 140-150 LOC100508689 Homo sapiens 0-5 22705400-4 2012 In the gallbladder, mucin is essential for best protection against detergent effect of high concentration of bile acids. Bile Acids and Salts 109-119 LOC100508689 Homo sapiens 20-25 18154934-0 2008 Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase. Bile Acids and Salts 39-49 LOC100508689 Homo sapiens 19-24 20198339-5 2010 These results provide new insight into the complex molecular mechanisms involved in the regulation of mucin gene by bile acids in colon cancer cells that may contribute to further elucidation of colorectal carcinogenesis. Bile Acids and Salts 116-126 LOC100508689 Homo sapiens 102-107 19014523-2 2008 Bile acids have been linked to esophageal adenocarcinoma and mucin secretion, but their effects on mucin gene expression in human esophageal adenocarcinoma cells is unknown. Bile Acids and Salts 0-10 LOC100508689 Homo sapiens 61-66 18154934-10 2008 CONCLUSIONS: Bile acids induce MUC1 mucin overexpression in human esophageal adenocarcinoma cells and tissues by activating its transcription through a process involving phosphatidylinositol 3-kinase. Bile Acids and Salts 13-23 LOC100508689 Homo sapiens 36-41 11230727-9 2001 These results provide evidence that bile acids may be transported mainly via ASBT in human gallbladder BEC and stimulate hydroelectrolytic and mucin secretion in these cells. Bile Acids and Salts 36-46 LOC100508689 Homo sapiens 143-148 11230727-10 2001 Individual bile acids activate different signaling pathways leading to a different balance between mucin and chloride secretion. Bile Acids and Salts 11-21 LOC100508689 Homo sapiens 99-104 9884402-5 1999 Both unconjugated bile salts as well as taurine conjugated bile salts stimulated mucin secretion by the colon cells in a dose-dependent fashion. Bile Acids and Salts 18-28 LOC100508689 Homo sapiens 81-86 9884402-0 1999 Mucin secretion by the human colon cell line LS174T is regulated by bile salts. Bile Acids and Salts 68-78 LOC100508689 Homo sapiens 0-5 9884402-2 1999 In this study we have examined whether bile salts also influence mucin secretion by the human epithelial colon cell line LS174T. Bile Acids and Salts 39-49 LOC100508689 Homo sapiens 65-70 9884402-5 1999 Both unconjugated bile salts as well as taurine conjugated bile salts stimulated mucin secretion by the colon cells in a dose-dependent fashion. Bile Acids and Salts 59-69 LOC100508689 Homo sapiens 81-86 9884402-8 1999 Stimulation of mucin secretion by LS174T cells was found to occur at much lower bile salt concentrations than in the experiments with the dog gallbladder epithelial cells. Bile Acids and Salts 80-89 LOC100508689 Homo sapiens 15-20 9884402-10 1999 We conclude that mucin secretion by the human colon epithelial cell line LS174T is regulated by bile salts. Bile Acids and Salts 96-106 LOC100508689 Homo sapiens 17-22 9884402-11 1999 We suggest that regulation of mucin secretion by bile salts might be a common mechanism, by which different epithelia protect themselves against the detergent action of bile salts, to which they are exposed throughout the gastrointestinal tract. Bile Acids and Salts 49-59 LOC100508689 Homo sapiens 30-35 9884402-11 1999 We suggest that regulation of mucin secretion by bile salts might be a common mechanism, by which different epithelia protect themselves against the detergent action of bile salts, to which they are exposed throughout the gastrointestinal tract. Bile Acids and Salts 169-179 LOC100508689 Homo sapiens 30-35 8729006-0 1996 Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Bile Acids and Salts 0-9 LOC100508689 Homo sapiens 33-38 8729006-13 1996 Thus, cytotoxic concentrations of bile acids induce mucin release, presumably due to detergent effects. Bile Acids and Salts 34-44 LOC100508689 Homo sapiens 52-57 8729006-15 1996 The bile acid-induced alterations in mucin production by enterocytes observed in vitro may influence intestinal cytoprotection in vivo. Bile Acids and Salts 4-13 LOC100508689 Homo sapiens 37-42 8729006-2 1996 Our aim was to determine the effect of bile acids on mucin, the primary constituent of mucous. Bile Acids and Salts 39-49 LOC100508689 Homo sapiens 53-58 8729006-5 1996 Short term (30 min) incubations with 1-5 mM unconjugated bile acids or taurodeoxycholic acid induced mucin release relative to bile acid hydrophobicity. Bile Acids and Salts 57-67 LOC100508689 Homo sapiens 101-106 8729006-5 1996 Short term (30 min) incubations with 1-5 mM unconjugated bile acids or taurodeoxycholic acid induced mucin release relative to bile acid hydrophobicity. Bile Acids and Salts 57-66 LOC100508689 Homo sapiens 101-106 8405867-1 1993 BACKGROUND: Arachidonic acid (AA) and hydrophobic bile salts (BS) stimulate gallbladder mucin (GBM) secretion, which is thought to be an essential step in gallstone pathogenesis. Bile Acids and Salts 50-60 LOC100508689 Homo sapiens 88-93 8119706-1 1994 The more hydrophobic bile salts cause rapid release of preformed gallbladder mucin and other glycoproteins by gallbladder explants in vitro, whereas the less hydrophobic bile salts elicit a lesser response. Bile Acids and Salts 21-31 LOC100508689 Homo sapiens 77-82 8405867-1 1993 BACKGROUND: Arachidonic acid (AA) and hydrophobic bile salts (BS) stimulate gallbladder mucin (GBM) secretion, which is thought to be an essential step in gallstone pathogenesis. Bile Acids and Salts 62-64 LOC100508689 Homo sapiens 88-93 35258349-4 2022 The concentrations of bile acids reaching the human colon range from 2-10mM; di-alpha-hydroxy bile acids are the only bile acids with detergent effects that include mucin depletion, mucosal damage, bacterial uptake, and microscopic inflammation that may be manifest in diseases associated with no overt inflammation of the mucosa, such as bile acid diarrhea, ileal diseases such as neuroendocrine tumors, ileal resection, and non-alcoholic steatohepatitis. Bile Acids and Salts 22-32 LOC100508689 Homo sapiens 165-170 6546237-10 1984 These findings suggest that inhibition of mucin release may prevent cholesterol stone formation during high-risk periods or after dissolution therapy with bile salts. Bile Acids and Salts 155-165 LOC100508689 Homo sapiens 42-47